| Project/Area Number |
20590933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
NAKAMURA Yutaka Iwate Medical University, 医学部, 講師 (60328614)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAUCHI Kohei 岩手医科大学, 医学部, 教授 (20200579)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | アレルギー / 遺伝子 / ゲノム / 細胞・組織 / シグナル伝達 / アレルギー・喘息 / SNP / 気道リモデリング / IL-13 / 吸入ステロイド / 気管支喘息 / 末梢気道障害 / 線維芽細胞 / 共培養 / 高用量ステロイド吸入療法 |
|---|
| Research Abstract |
We have demonstrated asthmatic patients with genetic variants of IL-13 Q110/Q110 (homozygous for glutamine) are significantly associated with a reduced pulmonary function in Japanese patients. An increased the protein level of IL-13, IL-23, IL-11, GM-CSF, hyaluronic acid, and CCL8/MCP-2 in bronchial lavage fluid were shown. We have observed that the subepithelial layer was significantly thicker in the biopsy samples taken from the patients with Q110/Q110 compared to wild type individuals. Our study demonstrates that Q110/Q110 increases, at least in part, allergic inflammation and the propensity for airway remodeling, thus resulting in low lung function.
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