Effect of genetic variation of IL-13 on airway remodeling in Bronchial asthma
| Project/Area Number |
20590933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
NAKAMURA Yutaka Iwate Medical University, 医学部, 講師 (60328614)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAUCHI Kohei 岩手医科大学, 医学部, 教授 (20200579)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | アレルギー / 遺伝子 / ゲノム / 細胞・組織 / シグナル伝達 / アレルギー・喘息 / SNP / 気道リモデリング / IL-13 / 吸入ステロイド / 気管支喘息 / 末梢気道障害 / 線維芽細胞 / 共培養 / 高用量ステロイド吸入療法 |
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| Research Abstract |
We have demonstrated asthmatic patients with genetic variants of IL-13 Q110/Q110 (homozygous for glutamine) are significantly associated with a reduced pulmonary function in Japanese patients. An increased the protein level of IL-13, IL-23, IL-11, GM-CSF, hyaluronic acid, and CCL8/MCP-2 in bronchial lavage fluid were shown. We have observed that the subepithelial layer was significantly thicker in the biopsy samples taken from the patients with Q110/Q110 compared to wild type individuals. Our study demonstrates that Q110/Q110 increases, at least in part, allergic inflammation and the propensity for airway remodeling, thus resulting in low lung function.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma.2011
Author(s)
Y Nakamura, H Nagashima, M Akiyama, A Sato, T Miyamoto, N Sasaki, N Nitanai, K Kowata, T Nakadate, H Kobayashi, N Uesugi, T Sugai, T Kakiuchi, H Inoue H, K Yamauchi
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Journal Title
International Archives of Allergy and Immunology 155
Pages: 129-140
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[Presentation] Essential roles of Q110 in IL13 in airway remodelling in bronchial asthma2009
Author(s)
Y Nakamura, T Shikanai, N Sasaki, H Nitanai, Y Nakajima, R Yoshizawa, K Izuhara, H Kanno, T Sawai, M Tamari, T Hirota, K Yamauchi, H Inoue
Organizer
19^<th> annual conference of the European Respiratory Society Vienna
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[Presentation] Effects of intervention with high-dose inhaled corticosteroids on airway remodelling in diagnosed genetic variants of IL13 with asthma2009
Author(s)
Yutaka Nakamura, Masachika Akiyama, Hiromi Nagashima, Nobuhito Sasaki, Hiroo Nitanai, Hiroyuki Kanno, Takashi Sawai, Tomomitsu Hirota, Mayumi Tamari, Kenji Izuhara, Kohei Yamauchi, Hiroshi Inoue
Organizer
20^<th> annual conference of the European Respiratory Society Barcelona
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