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Effect of genetic variation of IL-13 on airway remodeling in Bronchial asthma

Research Project

Project/Area Number 20590933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionIwate Medical University

Principal Investigator

NAKAMURA Yutaka  Iwate Medical University, 医学部, 講師 (60328614)

Co-Investigator(Renkei-kenkyūsha) YAMAUCHI Kohei  岩手医科大学, 医学部, 教授 (20200579)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsアレルギー / 遺伝子 / ゲノム / 細胞・組織 / シグナル伝達 / アレルギー・喘息 / SNP / 気道リモデリング / IL-13 / 吸入ステロイド / 気管支喘息 / 末梢気道障害 / 線維芽細胞 / 共培養 / 高用量ステロイド吸入療法
Research Abstract

We have demonstrated asthmatic patients with genetic variants of IL-13 Q110/Q110 (homozygous for glutamine) are significantly associated with a reduced pulmonary function in Japanese patients. An increased the protein level of IL-13, IL-23, IL-11, GM-CSF, hyaluronic acid, and CCL8/MCP-2 in bronchial lavage fluid were shown. We have observed that the subepithelial layer was significantly thicker in the biopsy samples taken from the patients with Q110/Q110 compared to wild type individuals. Our study demonstrates that Q110/Q110 increases, at least in part, allergic inflammation and the propensity for airway remodeling, thus resulting in low lung function.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (13 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma.2011

    • Author(s)
      Y Nakamura, H Nagashima, M Akiyama, A Sato, T Miyamoto, N Sasaki, N Nitanai, K Kowata, T Nakadate, H Kobayashi, N Uesugi, T Sugai, T Kakiuchi, H Inoue H, K Yamauchi
    • Journal Title

      International Archives of Allergy and Immunology 155

      Pages: 129-140

    • Related Report
      2010 Final Research Report
  • [Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma2011

    • Author(s)
      Yutaka Nakamura, et al.
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 155 Pages: 129-140

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of pulmonary allergic vasculitis with eosinophil infiltration in asthma model of miceExperimental2010

    • Author(s)
      Yamauchi K, Sasaki N, Niisato M, KamatakiA, Shikanai T, Nakamura Y, et al.
    • Journal Title

      Lung Research 36

      Pages: 227-236

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis of pulmonary allergic vasculitis with eosinophil infiltration in asthma model of mice.2010

    • Author(s)
      Yamauchi K, Sasaki N, Niisato M, Kamataki A, Shikanai T, Nakamura Y, et al.
    • Journal Title

      Experimental Lung Research

      Volume: 36 Pages: 227-236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new breath-holding test may non-invasively reveal early lung abnormalities caused by smoking and /or obesity.2009

    • Author(s)
      Inoue H, Yamauchi K, Kobayashi H, Shikanai T, Nakamura Y, et al.
    • Journal Title

      Chest 136

      Pages: 545-553

    • Related Report
      2010 Final Research Report
  • [Journal Article] Enhanced goblet cell hyperplasia in HDC knockout mice with allergic airway inflammation.2009

    • Author(s)
      Yamauchi K, Piao HM, Nakadate T, Shikanai T, Nakamura Y, et al.
    • Journal Title

      Allergology International 58

      Pages: 125-134

    • NAID

      10025109331

    • Related Report
      2010 Final Research Report
  • [Journal Article] Progress in allergy signal research on mast cells : the role of histamine in goblet cell hyperplasia in allergic airway inflammation-a study using the Hdc knockout mouse.2008

    • Author(s)
      Yamauchi K, Piao HM, Nakadate T, Shikanai T, Nakamura Y, et al.
    • Journal Title

      Journal of Pharmacological Science 106

      Pages: 54-60

    • NAID

      10024318852

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma.

    • Author(s)
      Hiromi Nagashima, Yutaka Nakamura, Hiroyuki Kanno, Takashi Sawai, Hiroshi Inoue, Kohei Yamauchi
    • Journal Title

      Allergology International in press

    • NAID

      130004723040

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma

    • Author(s)
      Hiromi Nagashima, Yutaka Nakamura, et al.
    • Journal Title

      Allergology International

      Volume: (In press)

    • NAID

      130004723040

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 気管支喘息患者のIL-13遺伝子多型と気道リモデリング2010

    • Author(s)
      中村豊
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of intervention with high-dose inhaled corticosteroids on airway remodelling in diagnosed genetic variants of IL13 with asthma2010

    • Author(s)
      Yutaka Nakamura
    • Organizer
      20^<th> annual conference of the European Respiratory Society
    • Place of Presentation
      バルセロナ
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気管支喘息患者のIL-13遺伝子多型と気道リモデリング関連分子2010

    • Author(s)
      中村豊、長島広相、佐藤温子、佐々木信人、似内郊雄、中舘俊英、小林仁、宮本孝行、菅野祐幸、澤井高志、出原賢治、玉利真由美、広田朝光、井上洋西、山内広平
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 気管支喘息患者のIL-13遺伝子多型と気道リモデリング2009

    • Author(s)
      中村豊
    • Organizer
      第46回日本臨床生理学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Essential roles of Q110 in IL13 in airway remodelling in bronchial asthma2009

    • Author(s)
      Y Nakamura
    • Organizer
      19^<th> annual conference of the European Respiratory Society
    • Place of Presentation
      Vienna
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気管支喘息患者におけるIL-13遺伝子多型と末梢気道病変予測2009

    • Author(s)
      中村豊
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気管支喘息患者におけるIL-13遺伝子多型と末梢気道病変予測2009

    • Author(s)
      中村豊
    • Organizer
      第43回東北アレルギー懇話会
    • Place of Presentation
      秋田
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気管支喘息患者におけるIL-13遺伝子多型と末梢気道病変予測2009

    • Author(s)
      中村豊
    • Organizer
      第5回呼吸器バイオマーカー研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-07
    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Presentation] Essential roles of Q110 in IL13 in airway remodelling in bronchial asthma2009

    • Author(s)
      Y Nakamura, T Shikanai, N Sasaki, H Nitanai, Y Nakajima, R Yoshizawa, K Izuhara, H Kanno, T Sawai, M Tamari, T Hirota, K Yamauchi, H Inoue
    • Organizer
      19^<th> annual conference of the European Respiratory Society Vienna
    • Related Report
      2010 Final Research Report
  • [Presentation] 気管支喘息患者のIL-13遺伝子多型と気道リモデリング (ワークショップ)2009

    • Author(s)
      中村豊、長島広相、鹿内俊樹、佐々木信人、似内郊雄、古和田浩子、宮本孝行、関村研之、佐藤温子、中舘俊英、小林仁、山内広平、井上洋西
    • Organizer
      第46回日本臨床生理学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 気管支喘息患者におけるIL-13遺伝子多型と気道リモデリング2009

    • Author(s)
      長島広相、中村豊、鹿内俊樹、佐々木信人、佐藤温子、似内郊雄、菅野祐幸、澤井高志、玉利真由美、広田朝光、出原賢治、山内広平、井上洋西
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] IL-13 遺伝子多型と気管支喘息との関連解析2009

    • Author(s)
      城道絢、広田朝光、原田通成、人見祐基、宮武明彦、土居悟、中村豊、井上洋西
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of intervention with high-dose inhaled corticosteroids on airway remodelling in diagnosed genetic variants of IL13 with asthma2009

    • Author(s)
      Yutaka Nakamura, Masachika Akiyama, Hiromi Nagashima, Nobuhito Sasaki, Hiroo Nitanai, Hiroyuki Kanno, Takashi Sawai, Tomomitsu Hirota, Mayumi Tamari, Kenji Izuhara, Kohei Yamauchi, Hiroshi Inoue
    • Organizer
      20^<th> annual conference of the European Respiratory Society Barcelona
    • Related Report
      2010 Final Research Report
  • [Book] [喘息の管理目標、定義、病型、診断、重症度]についてガイドライン/ガイダンス 気管支喘息

    • Author(s)
      中村豊、山内広平
    • Publisher
      日本医事新報社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://iwate-med.respir-dept.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://iwate-med.respir-dept.jp/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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