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The host defensive role of mast cells against airway viral infection.

Research Project

Project/Area Number 20590934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTeikyo University

Principal Investigator

NAGASE Hiroyuki  Teikyo University, 医学部, 准教授 (40365945)

Co-Investigator(Kenkyū-buntansha) OHTA Ken  帝京大学, 医学部, 教授 (30160500)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマスト細胞 / ウイルス / 二重鎖RNA / 気道感染 / 気管支喘息
Research Abstract

Mast cells have long been postulated to have a central role in the pathogenesis of allergic disease. In addition, it has been recently reported that mast cells also have a host defensive role against bacterial infection. But the role of mast cells against virus infection has not been clarified. The aim of the present study is to investigate the role of mast cells in host defense against viral infection. We intranasally inoculated poly I:C, which is an analogue compound of virus double-stranded RNA, into wild type or mast cell deficient W/Wv mice. Poly I : C induced lung inflammation in wild type mice, but the inflammation was diminished in mast cell deficient mice, and intravenous transfer of mast cells into mast cell deficient mice restored the inflammation. In addition, the local concentration of various chemokines and cytokines decreased in mast cell deficient mice. From those results, it was suggested that mast cells have a host-defensive role against viral infection via up-regulation of local cytokine and chemokine generation. This finding might contribute to clarify the mechanism of virus-induced exacerbation of allergic diseases including asthma.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (19 results) Book (3 results)

  • [Journal Article] Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils2011

    • Author(s)
      Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K
    • Journal Title

      J Immunol 186(9)

      Pages: 5254-5260

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.2011

    • Author(s)
      Suzukawa M, Nagase H, Ugahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K
    • Journal Title

      J Immunol.

      Volume: 186(9) Pages: 5254-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population2010

    • Author(s)
      Matsunaga K, Hirano T, Kawayama T, Tsuburai T, Nagase H, Aizawa H, Akiyama K, Ohta K, Ichinose M.
    • Journal Title

      Allergol Int 59(4)

      Pages: 363-367

    • NAID

      10029671105

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of tiotropium brmide on airway inflammation and remodelling in a mouse model of asthma2010

    • Author(s)
      Ohta S, Oda N, Yokoe T, Tanaka A, Yamamoto Y, Watanabe Y, Minoguchi K, Ohnishi T, Hirose T, Nagase H, Ohta K, Adachi M
    • Journal Title

      Clin Exp Allergy 40(8)

      Pages: 1266-1275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population.2010

    • Author(s)
      Matsunaga K, Hirano T, Kawayama T, Tsuburai T, Nagase H, Aizawa H, Akiyama K, Ohta K, Ichinose M.
    • Journal Title

      Allergol Int

      Volume: 59(4) Pages: 363-7

    • NAID

      10029671105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma.2010

    • Author(s)
      Ohta S, Oda N, Yokoe T, Tanaka A, Yamamoto Y, Watanabe Y, Minoguchi K, Ohnishi T, Hirose T, Nagase H, Ohta K, Adachi M.
    • Journal Title

      Clin Exp Allergy

      Volume: 40(8) Pages: 1266-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production2009

    • Author(s)
      Yamamura K, Adachi T, Masuda T, Kojima Y, Hara A, Toda T, Nagase H, Ohta K
    • Journal Title

      Int Arch Allergy Immunol 149(S1)

      Pages: 45-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー性気管支肺アスペルギルス症に続発した肺膿瘍が穿破し膿胸気管支瘻を呈した1例2009

    • Author(s)
      原麻恵,長瀬洋之,林秀敏,倉持美知雄,石田博文,足立哲也,鈴木直仁,大田健
    • Journal Title

      日本呼吸器学会雑誌 47

      Pages: 432-437

    • NAID

      10024824139

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production.2009

    • Author(s)
      Yamamura K, Adachi T, MasudaT, Kojima Y, Hara A, Toda T, Nagase H, Ohta K
    • Journal Title

      Int Arch Allergy Immunol 149 S1:

      Pages: 45-50

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー性気管支肺アスペルギルス症に続発した肺膿瘍が穿破し膿胸気管支馮瘻を呈した1例2009

    • Author(s)
      原麻恵, 長瀬洋之, 林秀敏, 倉持美知雄, 石田博文, 足立哲也, 鈴木直仁, 大田健
    • Journal Title

      日本呼吸器学会雑誌 47

      Pages: 432-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気管支喘息のモニタリングをめぐって 呼気ガス2009

    • Author(s)
      長瀬洋之、大田健
    • Journal Title

      臨床免疫・アレルギー科 52

      Pages: 194-8

    • Related Report
      2009 Annual Research Report
  • [Journal Article] An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor2008

    • Author(s)
      Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K. Yamamoto K, Yamaguchi M
    • Journal Title

      J Immunol 181

      Pages: 5981-5989

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An IL-1 cvtokine member IL-33 induces human basophil activation via its ST2 receptor.2008

    • Author(s)
      Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M.
    • Journal Title

      J Immunol 181

      Pages: 5981-5989

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気管支喘息のモニタリングをめぐって呼気ガス

    • Author(s)
      長瀬洋之,大田健
    • Journal Title

      臨床免疫・アレルギー科 52

      Pages: 194-198

    • Related Report
      2010 Final Research Report
  • [Presentation] Usefulness of measuring the level of fractional exhaled nitric oxide (FeNO) in various respiratory diseases2011

    • Author(s)
      H Nagase, T Toda, A Kamiyama, Y Nakase, N Sugimoto, H Yoshihara, M Kuramochi, H Tashimo, H Arai, M Yamaguchi, N Suzuki, K Ohta
    • Organizer
      2011 American Academy of Allergy Asthma & Immunol Annual Meeting (AAAAI)
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-03-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Usefulness of measuring the level of fractional exhaled nitric oxide (FeNO) in various respiratory diseases.2011

    • Author(s)
      H Nagase, T Toda, A Kamiyama, Y Nakase, N Sugimoto, H Yoshihara, M Kuramochi, H Tashimo, H Arai, M Yamaguchi, N Suzuki, K Ohta
    • Organizer
      2011 American Academy of Allergy Asthma & Immunol Annual Meeting (AAAAI)
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 喘息管理・コントロール状態の評価JGL2009、GINA、EPR3、喘息コントロールテスト(ACT)における喘息コントロール評価の比較2010

    • Author(s)
      長瀬洋之,戸田貴子,杉本直也,中瀬裕子,神山麻恵,吉原久直,倉持美知雄,田下浩之,新井秀宜,山口正雄,鈴木直仁,大田健
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 非喘息性呼吸器疾患における呼気一酸化窒素濃度(FeNO)測定の意義2010

    • Author(s)
      戸田貴子,長瀬洋之,神山麻恵,中瀬裕子,杉本直也,鈴川真穂,吉原久直,倉持美知雄,田下浩之,新井秀宜,中野純一,山口正雄,鈴木直仁, 大田健
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新型インフルエンザと喘息について多面的に考える成人領域における新型インフルエンザの臨床2010

    • Author(s)
      長瀬洋之,古賀一郎,太田康男,大田健
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 呼気一酸化窒素濃度(FeNO)の疾患特異性の検証2010

    • Author(s)
      戸田貴子,長瀬洋之,原麻恵,小河原郁子,鈴川真穂,小島康弘,倉持美知雄,田下浩之,新井秀宜,山口正雄,鈴木直仁,大田健
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] シリカによる慢性肺線維化モデル確立のための長期検討2010

    • Author(s)
      原麻恵,長瀬洋之,鈴川真穂,小河原郁子,戸田貴子,小島康弘,倉持美知雄,田下浩之,新井秀宜,山口正雄,鈴木直仁,大田健
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] シンポジウム4ウイルス・細菌・真菌とアレルギーS4-5 Innate Immunityとアレルギー2009

    • Author(s)
      長瀬洋之,大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] International Symposium Session 3 Activation and signaling in inflammatory cells : Expression and Function of Toll-like Receptors in Allergic Inflammatory Cells2009

    • Author(s)
      Nagase H, Hirai K, Yamaguchi M, Ohta K
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Th17系サイトカインが好酸球からのサイトカイン放出に及ぼす影響2009

    • Author(s)
      戸田貴子、長瀬洋之、鈴川真穂、原麻恵、小島康弘、倉持美知雄、田下浩之、新井秀宜、山口正雄、大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝子多型と吸入ステロイド(ICS)反応性との関連2009

    • Author(s)
      長瀬洋之、釣木澤尚実、原麻恵、松井永子、近藤直実、秋山一男、大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] The relationships between the levels of cytokines and chemokines in exhaled breath condensate and the control status of asthma2009

    • Author(s)
      Hara A, Nagase H, Kojima Y, Suzukawa M, Kuramochi M, Ishida H, Adachi T, Suzuki N, Ohta K
    • Organizer
      2009 American Academy of Allergy Asthma & Immunol Annual Meeting (AAAAI)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] The Effect of Diesel Exhaust Particles on Pathogen-associated Molecular Patterns induced Cytokine Generation from Bronchial Epithelial Cells2009

    • Author(s)
      Nagase H,, Takano H, Inoue K, Hara A, Kojima Y, Suzukawa M, Kuramochi M, Ishida H, Adachi T, Suzuki N, Ohta K
    • Organizer
      2009 American Academy of Allergy Asthma & Immunol Annual Meeting (AAAAI)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] ミニシンポジウム29-#2 Th17系サイトカインが好酸球からのサイトカイン放出に及ぼす影響2009

    • Author(s)
      戸田貴子、長瀬洋之、鈴川真穂、原麻恵、小島康弘、倉持美知雄、田下浩之、新井秀宜、山口正雄、大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミニシンポジウム4-#4 喘息治療ステップダウン成功因子としての呼気凝縮液/FeNOの検討2009

    • Author(s)
      原麻恵、長瀬洋之、小島康弘、倉持美知雄、田下浩之、新井秀宜、山口正雄、鈴木直仁、工藤宏一郎、小林信之、大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミニシンポジウム12-#3 遺伝子多型と吸入ステロイド(ICS)反応性との関連2009

    • Author(s)
      長瀬洋之、釣木澤尚実、原麻恵、松井永子、近藤直実、秋山一男、大田健
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田市
    • Related Report
      2009 Annual Research Report
  • [Presentation] The relationships between the levels of cytokines and chemokines in exhaled breath condensate and the control status of asthma.2009

    • Author(s)
      Hara A, Nagase H, Kojima Y, Suzukawa M, Kuramochi M, Ishida H, Adachi T, Suzuki N, Ohta K
    • Organizer
      2009 American Academy of Allergy Asthma & Im munol Annual Meeting (AAAAI)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 喘息患者におけるビーズアレイシステムを用いた呼気凝縮液の検討2008

    • Author(s)
      小島康弘,長瀬洋之,原麻恵,矢野智湖,鈴川真穂,石田博文,中野純一,足立哲也,鈴木直仁,大田健
    • Organizer
      第20回日本アレルギー学会春季臨床大会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation]2008

    • Author(s)
      中野純一, 足立哲也, 鈴木直仁, 大田 健
    • Organizer
      第20回日本アレルギー学会春季臨床大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] ~抗体治療時代の~気管支喘息治療の新たなストラテジー2010

    • Author(s)
      長瀬洋之
    • Total Pages
      182
    • Publisher
      先端医学社
    • Related Report
      2010 Annual Research Report
  • [Book] Annual Review呼吸器2008 IGF-1と呼吸器疾患2008

    • Author(s)
      長瀬洋之,大田健
    • Total Pages
      277
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review 呼吸器2008 IGF-1と呼吸器疾患40-43、20082008

    • Author(s)
      是瀬洋之, 大田 健
    • Total Pages
      277
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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