Functional analysis of Mycoplasma pneumoniae-derived lipoproteins in pneumonia onset
| Project/Area Number |
20590938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
KUWANO Koichi Kurume University, 医学部, 教授 (60215118)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takashi 久留米大学, 医学部, 助教 (40320155)
KIDA Yutaka 久留米大学, 医学部, 講師 (30309752)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 感染症 / 肺炎 / マイコプラズマ / 炎症 / リポプロテイン / TLR / Mycoplasma pneumoniae / 抗体 / サイトカイン / ELISA / 炎症性サイトカイン / ウエスタンブロット / アミノ酸 / FcR |
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| Research Abstract |
Mycoplasma pneumoniae is known to cause pneumonia in humans. It is, however, unclear how pneumonia occurs. Our laboratory previously reported that Mycoplasma pneumoniae-derived lipoproteins induce inflammatory responses. We then examined the interaction between the lipoproteins and host in order to elucidate the onset mechanisms. We found that the lipoproteins are extremely important in the onset of mycoplasma-pneumonia.
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Report
(4 results)
Research Products
(32 results)
