| Project/Area Number |
20590939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MORIMOTO Yasuo University of Occupational and Environmental Health, Japan, 産業生態科学研究所, 教授 (30258628)
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| Co-Investigator(Kenkyū-buntansha) |
MYOJO Toshihiko 産業医科大学, 産業生態科学研究所, 教授 (00209959)
HASHIBA Masayoshi 産業医科大学, 産業生態科学研究所, 専門修練医 (90566431)
TANAKA Isamu 産業医科大学, 産業生態科学研究所, 名誉教授 (00038035)
HIROHASHI Masami 産業医科大学, 産業生態科学研究所, 教務職員 (50389475)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノ粒子 / 肺障害 / キャラクタリゼーション / ハザード / 環境 / 化学物理 / ナノ材料 / 遺伝子 / 細胞・組織 / 病理学 / 肺傷害 |
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| Research Abstract |
We examined studies using characterized nano and fibrous materials in order to establish the estimating system of hazard effect of these materials. In intratracheal instillation studies, nickel oxide nanomaterials with agglomerates micron-size, high dose of titanium dioxide nanoparticles and potassium octatitanate Whiskers (PT-1) induced the pulmonary inflammation in rat lung. In vitro study using alveolar epithelial cell lines, nickel oxide induced IL-8 concentration and titanium dioxide did not. These studies are useful to estimate the harmful effect of nano and fibrous materials.
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