| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this study, the efficacy evaluation system in the transgenic medaka induced by deletion mutation of Pkd2 gene was not able to be established because of the problem of the breeding. However, in interferon-inducible Pkd1 conditional knockout mice, in which interferon was started at one week after birth as an early cyst formation group, remarkable cyst formation was observed. It was possible to evaluate the efficacy of mTOR inhibitor for cystic formation in these Pkd1 conditional knockout mice. It was suggested that these mice would be one of the model animals which could perform an efficacy evaluation system for treatment in polycystic kidney diseases.
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