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Generation of animal models and establishment of the drug-efficacy evaluation system in polycystic kidney disease.

Research Project

Project/Area Number 20590940
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionHokkaido University

Principal Investigator

MOCHIZUKI Toshio  Hokkaido University, 医学部, 講師 (00277120)

Co-Investigator(Kenkyū-buntansha) NISHIO Saori  北海道大学, 北海道大学病院, 助教 (90463736)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords多発性嚢胞腎 / ADPKD、PKD1、PKD2、PKD1ノックアウトマウス / トランスジェニックメダカ / ADPKD / PKD1 / PKD2 / PKD1ノックアウトマウス / Pkd1ノックアウトマウス
Research Abstract

In this study, the efficacy evaluation system in the transgenic medaka induced by deletion mutation of Pkd2 gene was not able to be established because of the problem of the breeding. However, in interferon-inducible Pkd1 conditional knockout mice, in which interferon was started at one week after birth as an early cyst formation group, remarkable cyst formation was observed. It was possible to evaluate the efficacy of mTOR inhibitor for cystic formation in these Pkd1 conditional knockout mice. It was suggested that these mice would be one of the model animals which could perform an efficacy evaluation system for treatment in polycystic kidney diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] 欠失変異体を用いた常染色体優性多発性嚢胞腎モデルメダカの解析2010

    • Author(s)
      石川康暢、西尾妙織、宮本兼玄、中垣祐、柴崎跡也、望月俊雄、小池隆夫
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 薬剤誘導型Pkd1コンディショナルノックアウトマウスに対するmTOR阻害薬の効果2010

    • Author(s)
      江端真一、西尾妙織、石川康暢、柴崎跡也、望月俊雄、小池隆夫
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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