Role of SOD in the pathogenesis of diabetic nephropathy

• Project/Area Number: 20590943
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Akita University
• Principal Investigator: FUJITA Hiroki Akita University, 医学部, 講師 (30333933)
• Co-Investigator(Kenkyū-buntansha): YAMADA Yuichiro 秋田大学, 大学院・医学系研究科, 教授 (60283610)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 糖尿病性腎症 / 酸化ストレス

Research Abstract

Superoxide dismutase (SOD) is a major anti-oxidant enzyme which scavenges superoxide anion. In the present study, we found that SOD is down-regulated in the kidneys of diabetic mice susceptible to nephropathy, leading to renal superoxide overproduction. Furthermore, we demonstrated that SOD mimetic dramatically prevents the progression of diabetic nephropathy in these mice via reducing renal superoxide production. We conclude that SOD plays an important role in preventing renal damage by oxidative stress inducing under chronic hyperglycemia.

Research Products

• [Journal Article] Reduction of renal superoxide dismutase in progressive diabetic nephropathy. (2009)
  • Author(s): Hiroki Fujita, Hiromi Fujishima, Shinsuke Chida, Keiko Takahashi, Zhonghua Qi, Yukiko Kanetsuna, Matthew Breyer, Raymond Harris, Yuichiro Yamada, Takamune Takahashi
  • Journal Title: J Am Soc Nephrol 20 Pages: 1303-1313
  • Peer Reviewed
• [Journal Article] Reduction of renal superoxide dismutase in progressive diabetic nephropathy (2009)
  • Author(s): 藤田浩樹, 山田祐一郎
  • Journal Title: Journal of the American Society of Nephrology 20 Pages: 1303-1313
  • Peer Reviewed
• [Presentation] SOD1, but not SOD3, deficiency causes diabetic nephropathy through reduction of glomerular endothelial nitric oxide in C57BL/6-Ins2^<Akita> mice (2010)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会Renal Week 2010
  • Place of Presentation: 米国Denver
  • Year and Date: 2010-11-18
• [Presentation] SOD1, but not SOD3, deficiency causes diabetic nephropathy through reduction of glomerular endothelial nitric oxide in C57BL/6-Ins2＾Akita mice (2010)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会ASN Renal Week 2010
  • Place of Presentation: 米国Denver
  • Year and Date: 2010-11-18
• [Presentation] Effects of telmisartan on renal NADPH oxidase, superoxide dismutase, and prostaglandin E2 in C57BL/6-Ins2^<Akita> diabetic mice (2009)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会Renal Week 2009
  • Place of Presentation: 米国San Diego
  • Year and Date: 2009-10-31
• [Presentation] Effects of telmisartan on renal NADPH oxidase, superoxide dismutase, and prostaglandin E_2 in C57BL/6-Ins2^<Akita> diabetic mice (2009)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会ASN Renal Week 2009
  • Place of Presentation: 米国San Diego
  • Year and Date: 2009-10-31
• [Presentation] Renal effects of superoxide dismutase 1 deficiency in nephropathy resistant C57BL/6-Ins2^<Akita> diabetic mice (2008)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会Renal Week 2008
  • Place of Presentation: 米国Philadelphia
  • Year and Date: 2008-11-07
• [Presentation] Renal effects of superoxide dismutase-1 deficiency in nephropathy-resistant C57BL/6-Ins2Akita diabetic mice (2008)
  • Author(s): 藤田浩樹
  • Organizer: 米国腎臓学会ASN Renal Week 2008
  • Place of Presentation: 米国Philadelphia
  • Year and Date: 2008-11-07
• [Remarks] ホームページ等
  • URL: http://www.med.akita-u.ac.jp