| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Label-retaining cells (LRCs) have been shown to act as the origin of proliferating cells after kidney injury. In the present study, we demonstrated that the number of LRCs as well as the area of the capillary network declined with aging. When renal tubules isolated from rats treated with BrdU label were co-cultured with human umbilical vein endothelial cells (HUVEC), the number of LRCs significantly increased compared to tubules cultured without HUVEC, suggesting that the size of LRC pool might be regulated by the surrounding peritubular capillary network.
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