Functional analysis of a novel glomerular specific gene and its application in the treatment of diabetic nephropathy.
| Project/Area Number |
20590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
TAKEMOTO Minoru Chiba University, 医学部附属病院, 助教 (60447307)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTE Koutaro 千葉大学, 大学院・医学研究院, 教授 (20312944)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 内科 / 腎臓病学 / 糖尿病性腎症 / 慢性腎臓病 / ポドサイト / TGFβ / 小胞体 |
|---|
| Research Abstract |
We identified R3h-domain containing like (R3h) as a podocyte-specific transcripts. The R3h knockout mice were created in order to know the function of R3h in vivo. Light microscopic analysis revealed that the R3h null mice had no observable glomerular developmental defects. However, an electron microscopic study revealed thickening of the glomerular basement membrane (GBM) and effacement of the podocyte foot processes. When they are induced diabetes by the injection of streptozotocin, R3h null mice produced more albuminuria and decreased renal functions than the wild type controls. We identified R3h as a novel podocyte's specific gene which might have a role in the development of diabetic glomerular disease.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.2011
Author(s)
Tsurutani Y, Fujimoto M, Takemoto M, Irisuna H, Koshizaka M, Onishi S, Ishikawa T, Mezawa M, He P, Honjo S, Maezawa Y, Saito Y, Yokote K.
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Journal Title
Biochem Biophys Res Commun.
Related Report
Peer Reviewed
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[Journal Article] Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.2011
Author(s)
Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG.
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Journal Title
Arterioscler Thromb Vasc Biol. 1
Pages: 151-159
Related Report
Peer Reviewed
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[Journal Article] Hypoglycemia due to Ectopic Secretion of Insulin-Like Growth Factor-I in a Patient with an Isolated Sarcoidosis of the Spleen.2010
Author(s)
Ogiwara Y, Mori S, Iwama M, Sawabe M, Takemoto M, Kanazawa N, Furuta K, Fukuda I, Kondo Y, Kimbara Y, Tamura Y, Chiba Y, Araki A, Yokote K, Maruyama N, Ito H.
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Journal Title
Endocrine Journal 57
Pages: 325-330
NAID
Related Report
Peer Reviewed
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[Journal Article] CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.2010
Author(s)
Shimoyama T, Hiraoka S, Takemoto M, Koshizaka M, Tokuyama H, Tokuyama T, Watanabe A, Fujimoto M, Kawamura K, Sato S, Tsurutani Y, Saito Y, Perbal B, Koseki H, Yokote K.
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Journal Title
Arterioscler Thromb Vasc Biol. 30
Pages: 675-682
Related Report
Peer Reviewed
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