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Functional analysis of a novel glomerular specific gene and its application in the treatment of diabetic nephropathy.

Research Project

Project/Area Number 20590947
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionChiba University

Principal Investigator

TAKEMOTO Minoru  Chiba University, 医学部附属病院, 助教 (60447307)

Co-Investigator(Kenkyū-buntansha) YOKOTE Koutaro  千葉大学, 大学院・医学研究院, 教授 (20312944)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords内科 / 腎臓病学 / 糖尿病性腎症 / 慢性腎臓病 / ポドサイト / TGFβ / 小胞体
Research Abstract

We identified R3h-domain containing like (R3h) as a podocyte-specific transcripts. The R3h knockout mice were created in order to know the function of R3h in vivo. Light microscopic analysis revealed that the R3h null mice had no observable glomerular developmental defects. However, an electron microscopic study revealed thickening of the glomerular basement membrane (GBM) and effacement of the podocyte foot processes. When they are induced diabetes by the injection of streptozotocin, R3h null mice produced more albuminuria and decreased renal functions than the wild type controls. We identified R3h as a novel podocyte's specific gene which might have a role in the development of diabetic glomerular disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (17 results) Book (7 results)

  • [Journal Article] The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.2011

    • Author(s)
      Tsurutani Y, Fujimoto M, Takemoto M, Irisuna H, Koshizaka M, Onishi S, Ishikawa T, Mezawa M, He P, Honjo S, Maezawa Y, Saito Y, Yokote K.
    • Journal Title

      Biochem Biophys Res Commun.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.2011

    • Author(s)
      Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 1

      Pages: 151-159

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular Podocytes Express Type 1 Adenylate Cyclase : Inactivation Results in Susceptibility to Proteinuria.2011

    • Author(s)
      Xiao Z, et al.
    • Journal Title

      Nephron Exp Nephrol

      Volume: 24 Pages: 39-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential endothelial transcriptomics identifies semaphorin 3G as avascular class 3 semaphorin.2011

    • Author(s)
      Kutschera S, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 1 Pages: 151-159

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglycemia due to Ectopic Secretion of Insulin-Like Growth Factor-I in a Patient with an Isolated Sarcoidosis of the Spleen.2010

    • Author(s)
      Ogiwara Y, Mori S, Iwama M, Sawabe M, Takemoto M, Kanazawa N, Furuta K, Fukuda I, Kondo Y, Kimbara Y, Tamura Y, Chiba Y, Araki A, Yokote K, Maruyama N, Ito H.
    • Journal Title

      Endocrine Journal 57

      Pages: 325-330

    • NAID

      10029584375

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.2010

    • Author(s)
      Shimoyama T, Hiraoka S, Takemoto M, Koshizaka M, Tokuyama H, Tokuyama T, Watanabe A, Fujimoto M, Kawamura K, Sato S, Tsurutani Y, Saito Y, Perbal B, Koseki H, Yokote K.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 675-682

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular Podocytes Express Type 1 Adenylate Cyclase : Inactivation Results in Susceptibility to Proteinuria.2010

    • Author(s)
      Xiao Z, He L, Takemoto M, Jalanko H, Chan GC, Storm DR, Betsholtz C, Tryggvason K, Patrakka J.
    • Journal Title

      Nephron Exp Nephrol. 24;118

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary lung cancer associated with Werner syndrome.2010

    • Author(s)
      Ohnishi S, Fujimoto M, Oide T, Nakatani Y, Tsurutani Y, Koshizaka M, Mezawa M, Ishikawa T, Takemoto M, Yokote K.
    • Journal Title

      Geriatr Gerontol Int. 10

      Pages: 319-323

    • NAID

      10027755431

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary lung cancer associated with Werner syndrome.2010

    • Author(s)
      Ohnishi S, et al.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Pages: 319-323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 inhibits neointimal hyperplasia through modulation of smoothmuscle cell growth and migration.2010

    • Author(s)
      Shimoyama T, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 30 Pages: 675-682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglycemia due to Ectopic Secretion of Insulin-Like Growth Factor-I in a Patient with an Isolated Sarcoidosis of the Spleen.2010

    • Author(s)
      Ogiwara Y, et al.
    • Journal Title

      Endocrine Journal

      Volume: 57 Pages: 325-330

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 inhibits neointimal hyperplasia through modulation of smooth muscl cell growth and migration.2010

    • Author(s)
      Shimoyama T
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 675-682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglycemia due to Ectopic Secretion of Insulin-Like Growth Factor-I in a Patient with an Isolated Sarcoidosis of the Spleen.2010

    • Author(s)
      Ogawa Y
    • Journal Title

      Endocrine Journal (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular Transcriptome Changes Associated with Lipopolysaccharide-ln duced Proteinuria2009

    • Author(s)
      Sun Y
    • Journal Title

      Am J Nephrol 29

      Pages: 558-570

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Halofuginone prevents extracellular matrix deposition in diabetic nephropathv.2009

    • Author(s)
      Sato S
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 411-416

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimal change nephrotic syndrome associated with IPEX syndrome2009

    • Author(s)
      Hashimura Y
    • Journal Title

      Pediatric Nephrology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome and mechanism of soft tissue calcification in Werner syndrome.2008

    • Author(s)
      Honjo S
    • Journal Title

      Rejuvenation Res. 11

      Pages: 809-819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of TGF-b/Smad3 signaling in the pathogenesis of obese fat tissue.2011

    • Author(s)
      鶴谷悠也, 藤本昌紀, 竹本稔, 横手幸太郎
    • Organizer
      46^<th> European association the study of diabetes annual meeting.
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Final Research Report
  • [Presentation] Rah-Domain Containing Like Protein Is a Novel Regulator of Glomerular Basement Membrane2010

    • Author(s)
      Takahiro Ishikawa, et al.
    • Organizer
      アメリカ腎臓病学会(ASN)
    • Place of Presentation
      Denver, Co, USA
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Telmisartan, an angiotensin II type l receptor Mocker, prevents renalinjury via inhibition of the Notch pathway in Ins2 Akita diabetic mice2010

    • Author(s)
      Koshizaka Masaya, et al.
    • Organizer
      ヨーロッパ糖尿病学会(EASD)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウエルナー症候群の病態把握、診療指針作成と新規治療法の開発を目的とした全国研究2010

    • Author(s)
      石川崇弘、竹本稔、藤本昌紀、葛谷雅文、森聖二郎、横手幸太郎
    • Organizer
      第52回日本老年病医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Telmisartanは非肥満1型糖尿病モデルマウスであるAkitaマウスにおいてNotch経路抑制作用を介して腎障害を軽減する2010

    • Author(s)
      越坂昌也, 他
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「ポドサイト特異的遺伝子R3hdmlの機能に関する検討2010

    • Author(s)
      石川崇広、竹本稔、秋元義弘、楊國昌、横手幸太郎
    • Organizer
      第22回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] TGF-b/Smad3シグナルの肥満脂肪組織における役割について2010

    • Author(s)
      鶴谷悠也、藤本昌紀、竹本稔、横手幸太郎
    • Organizer
      第31回日本肥満学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2010 Final Research Report
  • [Presentation] フォーミュラ食を用いた入院VLCD療法前後の運動療法の重要性2010

    • Author(s)
      北原綾、野口尚子、藤本昌紀、鶴谷悠也、石川崇広、大西俊一郎、目澤守人、竹本稔、武城英明、横手幸太郎
    • Organizer
      第3回日本肥満症治療学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of TGF-b/Smad3 signaling in the pathogenesis of obese fat tissue2010

    • Author(s)
      鶴谷悠也、藤本昌紀、竹本稔、横手幸太郎
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2010 Final Research Report
  • [Presentation] TGF-b/Smad3シグナルの肥満脂肪組織における役割について2010

    • Author(s)
      鶴谷悠也、藤本昌紀、竹本稔、横手幸太郎
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満脂肪組織におけるTGF-b/Smad3シグナルの役割について2010

    • Author(s)
      鶴谷悠也、藤本昌紀、竹本稔、横手幸太郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] 2型糖尿病患者における還元型コエンザイムQ10(CoQ10)の血糖値, 血圧に対する影響2009

    • Author(s)
      目澤守人
    • Organizer
      日本臨床内科医学会
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 還元型コエンザイムQ10(CoQ10)併用療法は2型糖尿病患者の血糖コントロールを改善し、収縮期血圧を有意に低下させる。2009

    • Author(s)
      石橋亮一
    • Organizer
      第50回関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性腎臓病の発症機序解明の為の大規模な糸球体特異的遺伝子の同定とその機能解析2009

    • Author(s)
      竹本稔
    • Organizer
      第52回 日本糖尿病学会年次学術集会 シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性腎臓病の発症機序解明の為の大規模な糸球体特異的遺伝子の同定とその機能解析2008

    • Author(s)
      竹本稔
    • Organizer
      日本老年医学会学術集会
    • Place of Presentation
      幕張メッセ国際会議場
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大規模な糸球体特異的遺伝子の同定とその機能解析2008

    • Author(s)
      竹本稔
    • Organizer
      日本腎臓病学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖尿病性腎症の機序解明の為の大規模な糸球体特異的遺伝子の同定とその機能解析2008

    • Author(s)
      竹本稔
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Book] 高血圧診療ガイド(2010)2010

    • Author(s)
      王子剛, 他
    • Total Pages
      293
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] 脂質異常症診療Q&A2010

    • Author(s)
      平良暁子, 他
    • Total Pages
      184
    • Publisher
      日本医学出版
    • Related Report
      2010 Annual Research Report
  • [Book] レジンの効果とスタチンの併用療法 見直されたレジン 陰イオン交換樹脂 その位置づけと使い方2009

    • Author(s)
      岡部恵美子, 他
    • Total Pages
      5
    • Publisher
      フジメディカル出版
    • Related Report
      2009 Annual Research Report
  • [Book] ガイドラインに準じた循環器治療薬ファーストブック2009

    • Author(s)
      竹本稔
    • Total Pages
      13
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report
  • [Book] Heart View特集MetSとCKD:新たなリスク関連2009

    • Author(s)
      目澤守人, 他
    • Total Pages
      6
    • Publisher
      株式会社 メディカルビュー社
    • Related Report
      2009 Annual Research Report
  • [Book] 高度肥満と糖尿病に著しい高トリグリセライド血症を合併した1例2009

    • Author(s)
      石橋亮一, 他
    • Total Pages
      2
    • Publisher
      Medical Practice
    • Related Report
      2009 Annual Research Report
  • [Book] 細胞The cell2009

    • Author(s)
      下山達志
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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