Renal regeneration by human Embryonic Stem cells
| Project/Area Number |
20590948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HISHIKAWA Keiichi The University of Tokyo, 医学部附属病院, 特任准教授 (50255460)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ES細胞 / 再生医療 / HDAC阻害薬 / 脱メチル化剤 / 3次元培養 / 腎臓 / 発生 / WT-1 |
|---|
| Research Abstract |
5-Aza-2'-deoxycytidine (5-Aza) effecectively induced WT-1 in human embryonic stem cells, KhES-1, 2 and 3. Next we transplanted 5-Aza treated KhES-1, 2 and 3 into the kidney capsule of SCID mice. After 6-24 weeks, we found generation of kidney tubular cells, but not endothelial cells and podocytes. Our results demonstrated that 5-Aza promotes differentiation of human ES cells to kidney cells, especially tubular cells.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Histone deacetylase modulates the proinflammatory and-fibrotic changes in tubulointerstitial injury2010
Author(s)
Marumo, T., Hishikawa, K., Yoshikawa, M., Hirahashi, J., Kawachi, S., Fujita, T.
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Journal Title
Am J Physiol Renal Physiol
Volume: 298
Pages: 133-141
Related Report
Peer Reviewed
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[Journal Article] Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.2009
Author(s)
Hirahashi J., Hishikawa K., Kaname S., Tsuboi N., Wang Y., Simon D.I., Stavrakis G., Shimosawa T., Xiao L., Nagahama Y., et al.
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Journal Title
Circulation 120
Pages: 1255-126
Related Report
Peer Reviewed
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