| Project/Area Number |
20590951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
|
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| Research Institution | Niigata University |
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Principal Investigator |
GOTO Shin Niigata University, 医歯学系, 助教 (00463969)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
YAMAMOTO Tadashi 新潟大学, 医歯学系, 教授 (30092737)
IGUCHI Seitaro 新潟大学, 大学院・医歯学総合研究科, 特任教授 (20420309)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ADAMTS-8 / transgenic rat / proteome / nephrotic syndrome / phage display / proteinuria / immunoprecipitation |
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| Research Abstract |
Nephrotic syndrome present massive proteinuria, however, underling mechanisms remain elusive. We focused an interaction between the cell-cell contact which is involved with urine production, and proteinase produced in these cells (ADAMTS-8). Rat with forced expression of ADAMTS-8 gradually showed proteinuria. Using these rat model, we revealed molecules associated with development of proteinuria.
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