Possible involvement of CD45^+/collagen I^+ dual positive cells in renal fibrosis and cardiorenal syndrome.
| Project/Area Number |
20590952
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
WADA Takashi Kanazawa University, 医学系, 教授 (40334784)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 炎症 / 免疫担当細胞 / CD45 / 心臓病 / 腎臓病 / 線維化 / コラーゲン / 臨床検査診断 / fibrocyte / 血尿 / 腎機能 / ケモカイン / 腎臓 / レニン / アンジオテンシン |
|---|
| Research Abstract |
CD45^<+/>Collagen I^+ dual positive cells migrate into fibrotic kidney dependent on chemokine system, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating renal fibrosis. In addition, our present data suggest the possible involvement of CD45^+/Collagen I^+ dual positive cells in cardiac fibrosis, closely related to renal lesions. Furthermore, the detection of CD45^+/Collagen I^+ dual positive cells in circulation has been established in this study.
|
Report
(4 results)
Research Products
(41 results)
-
-
-
[Journal Article] Fibrocytes are involved in the pathogenesis of human chronic kidney disease.2010
Author(s)
Sakai N, Furuichi K, Shinozaki Y, Yamauchi H, Toyama T, Kitajima S, Okumura T, Kokubo S, Kobayashi M, Takasawa K, Takeda SI, Yoshimura M, Kaneko S, Wada T.
-
Journal Title
Hum Pathol. 41
Pages: 672-678
NAID
Related Report
Peer Reviewed
-
[Journal Article] Involvement of CD11b(+) GR-1 (low) cells in autoimmune disorder in MRL-Fas^<lpr> mouse.2010
Author(s)
Iwata Y, Furuichi K, Kitagawa K, Hara A, Okumura T, Kokubo S, Shimizu K, Sakai N, Sagara A, Kurokawa Y, Ueha S, Matsushima K, Kaneko S, Wada T.
-
Journal Title
Clin Exp Nephrol. 14
Pages: 411-417
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Dendritic cells contribute to autoimmune kidney injury in MRL-Fas^<lpr> mice2009
Author(s)
Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Zhou H, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T.
-
Journal Title
J Rheumatol. 36
Pages: 306-314
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] IFN-inducible Protein 10 (CXCL10) Regulates Tubular Cell Proliferation in Renal Ischemia-Reperfusion Injury.2008
Author(s)
Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, Kawachi H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, Kaneko S.
-
Journal Title
Nephron Exp Nephrol. 109
Pages: 29-38
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 炎症と腎線維化2009
Author(s)
和田隆志
Organizer
第82回日本生化学会大会
Place of Presentation
神戸ポートピアホテル(兵庫県)
Year and Date
2009-10-23
Related Report
-
[Presentation] 炎症と腎線維化2009
Author(s)
和田隆志
Organizer
第82回日本生化学会大会
Place of Presentation
神戸ポートピアホテル(兵庫)
Year and Date
2009-10-23
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
