Role of intercellular communication in the control of renin secretion
| Project/Area Number |
20590953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
YAO Jian University of Yamanashi, 大学院・医学工学総合研究部, 准教授 (50303128)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Masanori 山梨大学, 大学院・医学工学総合研究部, 教授 (90333062)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生理学 / 腎臓 / シグナル伝達 / レニン / ギャップ結合 / コネクシン / レニン分泌細胞 / 細胞間コミュニケーション / cAMP / 傍糸球体装置 / 腎臟 |
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| Research Abstract |
Renin plays an important role in the maintenance of blood pressure and renal blood flow. A lot paracrine factors such as neurotransmitters, vasoactive materials, growth factors and cytokines have been shown to be implicated in the control of renin. However, our understanding about the mechanisms of the gap junction-mediated direct intercellular communication in renin secretion is still lacking. Here, we investigated the role of gap junctions in the control of renin production in juxtaglomerular cells. Our results demonstrated that : 1) there are abundant connexins and functional gap junctions in renin-secreting cells ; 2) dysfunction of gap junctions with gap junction blockers stimulated the expression of COX_2, an important signal molecule implicated in the stimulation of renin synthesis and production ; and 3) the opening of gap junction hemichannls under low calcium conditions activated the renin-stimulating cAMP signaling pathway. Our results thus implicate gap junctions as an important regulator of renin secretion and production.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB.2010
Author(s)
Tamai M, Shimada T, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Takahashi S, Nakajima S, Yao J, Kitamura M
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Journal Title
Lab Invest 90
Pages: 1385-1395
Related Report
Peer Reviewed
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