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Molecular mechanism of epithelialization by non-peptide, endogenous siderophores

Research Project

Project/Area Number 20590955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University

Principal Investigator

MORI Kiyoshi  Kyoto University, 大学院・医学研究科, 特定准教授 (60343232)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords腎臓学 / 生体分子 / 鉄 / 有機化学 / 腎不全 / リポカリン / バイオマーカー / 内科 / 腎臓内科学
Research Abstract

Neutrophil gelatinase-associated lipocalin (Ngal or LCN2) has a renoprotective activity, which is enhanced by the presence of enterochelin, an E. coli-derived siderophore [Mori et al. J Clin Invest 2005]. Purification of mammalian siderophores lead to identification of catechol and its derivatives [Bao et al. Nat Chem Biol 2010]. Catechol largely affects tissue distribution of iron in mammals. Ngal plays a renoprotective role in renal ischemia-reperusion injury, whereas enhances renal hypertrophy and kidney injury in 3/4 subtotal nephrectomy [Viau et al. J Clin Invest 2005]. Urinary Ngal levels are determined by renal synthesis, release from neutrophils, and impaired reabsorption at proximal tubules [Kuwabara et al. Kidney Int 2009]. Urinary Ngal is useful for the evaluation of disease severity and treatment efficacy of chronic kidney disease [Kasahara et al. Nephrol Dial Trasplant 2009]. Ngal reporter mice allow real-time visualization of spaciotemporal regulation of Ngal expression, and its changes by treating reagents [Paragas et al. Nat Med 2011].

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (103 results)

All 2011 2010 2009 2008 Other

All Journal Article (51 results) (of which Peer Reviewed: 28 results) Presentation (49 results) Remarks (3 results)

  • [Journal Article] The Ngal reporter mouse detects the response of the kidney to injury in real time.2011

    • Author(s)
      N Paragas, A Qiu, Q Zhang, B Samstein, SX Deng, KM Schmidt-Ott, M Viltard, W Yu, CS Forster, G Gong, Y Liu, R Kulkarni, K Mori, A Kalandadze, AJ Ratner, P Devarajan, DW Landry, V D'Agati, CS Lin, J Barasch.
    • Journal Title

      Nat Med 17

      Pages: 216-222

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害(AKI)の診療 : Ngal.2011

    • Author(s)
      森潔、桑原孝成、今牧博貴、笠原正登、川西智子、横井秀基、向山政志、中尾一和
    • Journal Title

      Modern Physician(新興医学出版社) 31

      Pages: 87-89

    • Related Report
      2010 Final Research Report
  • [Journal Article] 急性腎障害のバイオマーカー2011

    • Author(s)
      森潔、中尾一和
    • Journal Title

      腎疾患透析最新の治療2011-2013(南江堂)

      Pages: 295-298

    • Related Report
      2010 Final Research Report
  • [Journal Article] The Ngal reporter mouse detects the response of the kidney to injury in real time.2011

    • Author(s)
      N.Paragas, et al.
    • Journal Title

      Nat Med

      Volume: 17 Pages: 216-222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害(AKI)の診療:Ngal2011

    • Author(s)
      森潔, ほか
    • Journal Title

      Modern Physician

      Volume: 31 Pages: 87-89

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 急性腎障害のバイオマーカー2011

    • Author(s)
      森潔, ほか
    • Journal Title

      腎疾患透析最新の治療2011-2013

      Pages: 295-298

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application.2010

    • Author(s)
      K Mori, M Mukoyama, K Nakao
    • Journal Title

      Clin Exp Nephrol 14

      Pages: 523-527

    • NAID

      10029321075

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.2010

    • Author(s)
      A Viau, K El Karoui, D Laouari, M Burtin, C Nguyen, K Mori, E Pillebout, T Berger, TW Mak, B Knebelmann, G Friedlander, J Barasch, F Terzi.
    • Journal Title

      J Clin Invest 120

      Pages: 4065-4076

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.2010

    • Author(s)
      G Bao, M Clifton, TM Hoette, K Mori, SX Deng, A Qiu, M Viltard, D Williams, N Paragas, T Leete, R Kulkarni, X Li, B Lee, A Kalandadze, AJ Ratner, JC Pizarro, KM Schmidt-Ott, DW Landry, KN Raymond, RK Strong, J Barasch.
    • Journal Title

      Nat Chem Biol 6

      Pages: 602-609

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010

    • Author(s)
      H Yokoi, M Kasahara, M Mukoyama, K Mori, K Kuwahara, J Fujikura, Y Arai, Y Saito, Y Ogawa, T Kuwabara, A Sugawara, K Nakao
    • Journal Title

      Nephrol Dial Transplant 25

      Pages: 2120-2124

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 微生物の鉄捕捉分子と生体の防御機構2010

    • Author(s)
      森潔,向山政志,中尾一和
    • Journal Title

      日本内科学会雑誌(日本内科学会) 99

      Pages: 1188-1193

    • NAID

      10026426240

    • Related Report
      2010 Final Research Report
  • [Journal Article] AKI・急性腎不全の早期診断マーカーの開発2010

    • Author(s)
      森潔、向山政志、中尾一和
    • Journal Title

      日本腎臓学会誌(日本腎臓学会) 52

      Pages: 566-571

    • NAID

      10026608005

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新規バイオマーカー尿中Ngalによる慢性腎臓病の重症度、治療効果及び予後の評価2010

    • Author(s)
      森潔、桑原孝成、今牧博貴、川西智子、笠原正登、横井秀基、向山政志、中尾一和
    • Journal Title

      腎臓(日本腎臓財団) 33

      Pages: 109-112

    • Related Report
      2010 Final Research Report
  • [Journal Article] AKIの診断・バイオマーカー(AKIとCKDのすべて).2010

    • Author(s)
      森潔、向山政志、中尾一和
    • Journal Title

      腎と透析(東京医学社) 69

      Pages: 341-343

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.2010

    • Author(s)
      A.Viau, et al.
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 4065-4076

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.2010

    • Author(s)
      G.Bao, et al.
    • Journal Title

      Nat Chem Biol

      Volume: 6 Pages: 602-609

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application.2010

    • Author(s)
      K.Mori, et al.
    • Journal Title

      Clin Exp Nephrol

      Volume: 14 Pages: 523-527

    • NAID

      10029321075

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010

    • Author(s)
      H.Yokoi, et al.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Pages: 2120-2124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AKI・急性腎不全の早期診断マーカーの開発2010

    • Author(s)
      森潔, ほか
    • Journal Title

      日本腎臓学会誌

      Volume: 52 Pages: 566-571

    • NAID

      10026608005

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 微生物の鉄捕捉分子と生体の防御機構2010

    • Author(s)
      森潔, ほか
    • Journal Title

      日本内科学会誌

      Volume: 99 Pages: 1188-1193

    • NAID

      10026426240

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 尿中L-FABP2010

    • Author(s)
      森潔, ほか
    • Journal Title

      循環器臨床サピア

      Volume: 7 Pages: 47-48

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 新規バイオマーカー尿中Ngalによる慢性腎臓病の重症度、治療効果及び予後の評価2010

    • Author(s)
      森潔, ほか
    • Journal Title

      腎臓(日本腎臓財団編)

      Volume: 33 Pages: 109-112

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 腎臓における尿中バイオマーカーNgalおよびアルブミンの代謝2010

    • Author(s)
      森潔, ほか
    • Journal Title

      Pharma Medica

      Volume: 28 Pages: 242-245

    • Related Report
      2010 Annual Research Report
  • [Journal Article] AKIの診断・バイオマーカー(AKIとCKDのすべて)2010

    • Author(s)
      森潔, ほか
    • Journal Title

      腎と透析

      Volume: 69 Pages: 341-343

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 好中球ゼラチナーゼ関連リポカリン(neutrophil gelatinase-associated lipocalin : Ngal)2010

    • Author(s)
      森潔, ほか
    • Journal Title

      Vascular Medicine

      Volume: 6 Pages: 309-313

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 微生物の鉄捕捉分子と生体の防御機構2010

    • Author(s)
      森潔, ほか
    • Journal Title

      日本内科学会誌 (印刷中)

    • NAID

      10026426240

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal and distal nephrons.2009

    • Author(s)
      T Kuwabara, K Mori, M Mukoyama, M Kasahara, H Yokoi, Y Saito, T Yoshioka, Y Ogawa, H Imamaki, T Kusakabe, K Ebihara, M Omata, N Satoh, A Sugawara, J Barasch, K Nakao
    • Journal Title

      Kidney Int 75

      Pages: 285-294

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction in urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blockers in hypertensive patients.2009

    • Author(s)
      M Kasahara, K Mori, N Satoh, T Kuwabara, H Yokoi, A Shimatsu, A Sugawara, M Mukoyama, K Nakao
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 2608-2609

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells.2009

    • Author(s)
      LT Zheng, S Lee, GN Yin, K Mori, K Suk.
    • Journal Title

      J Neurochem 111

      Pages: 1238-1251

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipocalin-2 is an autocrine mediator of reactive astrocytosis.2009

    • Author(s)
      S Lee, JY Park, WH Lee, H Kim, HC Park, K Mori, K Suk.
    • Journal Title

      J Neurosci 29

      Pages: 234-249

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] siderophore結合蛋白の生物学--分化誘導、組織障害、癌、感染、造血の新しい接点--2009

    • Author(s)
      森潔、向山政志、中尾一和
    • Journal Title

      臨床血液(日本血液学会) 50

      Pages: 519-526

    • NAID

      10025223566

    • Related Report
      2010 Final Research Report
  • [Journal Article] CKDにおける新規バイオマーカーNgalの意義2009

    • Author(s)
      森潔、向山政志、桑原孝成、笠原正登、横井秀基、中尾一和
    • Journal Title

      日本臨牀(日本臨牀社) 67

      Pages: 1233-1241

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blocker in hypertensive patients.2009

    • Author(s)
      M.Kasahara, et al.
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 2608-2609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.2009

    • Author(s)
      T.Kuwabara, et al.
    • Journal Title

      Kidney Int 75

      Pages: 285-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipocalin-2 is an autocrine mediator of reactive astrocytosis.2009

    • Author(s)
      S.Lee, et al.
    • Journal Title

      J Neurosci 29

      Pages: 234-249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells.2009

    • Author(s)
      L.T.Zheng, et al.
    • Journal Title

      J Neurochem 111

      Pages: 1238-1251

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Siderophore結合蛋白の生物学~分化誘導、組織障害、癌、感染、造血の新しい接点~2009

    • Author(s)
      森潔, ほか
    • Journal Title

      臨床血液 50

      Pages: 519-526

    • NAID

      10025223566

    • Related Report
      2009 Annual Research Report
  • [Journal Article] CKDにおける新規バイオマーカーNgalの意義2009

    • Author(s)
      森潔, ほか
    • Journal Title

      日本臨床 67

      Pages: 1233-1241

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blocker in hypertensive patients.2009

    • Author(s)
      M. Kasahara, et al.
    • Journal Title

      Nephrol Dial Transplant (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.2009

    • Author(s)
      T. Kuwabara, et al.
    • Journal Title

      Kidney Int 75

      Pages: 285-294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipocalin-2 is an autocrine mediator of reactive astrocytosis.2009

    • Author(s)
      S. Lee, et al.
    • Journal Title

      J Neurosci 29

      Pages: 234-249

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siderophore結合蛋白の生物学〜分化誘導、組織障害、癌、感染、造血の新しい接点〜.2009

    • Author(s)
      森潔, ほか
    • Journal Title

      臨床血液 (印刷中)

    • NAID

      10025223566

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008

    • Author(s)
      T Nagae, K Mori, M Mukoyama, M Kasahara, H Yokoi, T Suganami, K Sawai, T Yoshioka, M Koshikawa, Y Saito, Y Ogawa, T Kuwabara, I Tanaka, A Sugawara, T Kuwahara, K Nakao
    • Journal Title

      Kidney Int 74

      Pages: 70-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury.2008

    • Author(s)
      TL Nickolas, MJ O'Rourke, J Yang, ME Sise, PA Canetta, N Barasch, C Buchen, F Khan, K Mori, J Giglio, P Devarajan, J Barasch.
    • Journal Title

      Ann Intern Med 148

      Pages: 810-819

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2008

    • Author(s)
      H Yokoi, M Mukoyama, K Mori, M Kasahara, T Suganami, K Sawai, T Yoshioka, Y Saito, Y Ogawa, T Kuwabara, A Sugawara, K Nakao
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多彩な生命現象に関わる鉄結合性小化合物siderophoreの意義2008

    • Author(s)
      森潔、向山政志、中尾一和
    • Journal Title

      細胞工学(秀潤社) 27

      Pages: 226-230

    • Related Report
      2010 Final Research Report
  • [Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipooalin for diagnosing acute kidney injuiry.2008

    • Author(s)
      T. L. Nickolas, et al.
    • Journal Title

      Ann Intern Med 148

      Pages: 810-819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008

    • Author(s)
      T. Nagae, et al.
    • Journal Title

      Kidney Int 74

      Pages: 70-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2008

    • Author(s)
      H. Yokoi, et al.
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多彩な生命現象に関わる鉄結合性小化合物siderophoreの意義.2008

    • Author(s)
      森潔, ほか
    • Journal Title

      細胞工学 27

      Pages: 226-230

    • Related Report
      2008 Annual Research Report
  • [Journal Article] CKDの新規バイオマーカーI(尿)2008

    • Author(s)
      森潔, ほか
    • Journal Title

      Cardiac Practice 19

      Pages: 25-30

    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanism of albuminuria in diabetic nephropathy--urinary intact albumin and incomplete tubular compensation model.2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      日本糖尿病学会学術集会(招待講演)
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Reverse epidemiology of circulating Ngal (or lipocalin 2) levels in end-stage renal disease.2010

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      International Society of Nephrology (ISN) Nexus Symposium.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] The kidney and neutrophil as the sources of an acute kidney injury biomarker Ngal.2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Society of Nephrology (ISN) Nexus Symposium.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Incomplete tubular compensation model for albuminuria in diabetic nephropathy.2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Society of Nephrology (ISN) Nexus Symposium.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] How can we improve renal outcome by use of heart hormones?2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Meeting of Cardiovascular Endocrinology and Metabolism (招聘講演)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Association of Serum Neutrophil-Gelatinase Associated Lipocalin Levels with Nutritional Status and Circulating White Blood Cell Counts in Maintenance Hemodialysis Patients.2010

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      Cardiovascular Endocrinology and Metabolism (CVEM).
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] How can we improve renal outcome by use of heart hormones?2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      Cardiovascular Endocrinology and Metabolism (CVEM、招聘講演)
    • Place of Presentation
      Nara
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neutrophils are the predominant source of circulating Ngal in normal conditions and during infection, but not in acute kidney injury.2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Congress of Endocrinology (ICE).
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] The kidney is an exocrine organ : Rapid expression of NGAL defends the urinary tract.2010

    • Author(s)
      J.Barasch, K.Mori, et al.
    • Organizer
      International Congress of Endocrinology (ICE).
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Neutrophils are the predominant source of circulating Ngal in normal conditions and during infection, but not in acute kidney injury2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Congress of Endocrinilogy (ICE)
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nutritional status but not iron determines serum neutrophil gelatinase-associated lipocalin (Ngal) levels in maintenance hemodialyis patients.2010

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      International Congress of Endocrinology (ICE).
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Angiotensin receptor blocker (ARB) reduces urinary concentrations of neutrophil gelatinase-associated lipocalin (Ngal) in diabetes and obesity.2010

    • Author(s)
      M.Kasahara, K.Mori, et al.
    • Organizer
      International Congress of Endocrinology (ICE).
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] How can we improve renal outcome by use of heart hormones?2010

    • Author(s)
      K.Mori, et al
    • Organizer
      International Meeting of Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of serum neutrophil-gelatinase associated lipocalin levels with nutritional status and circulating white blood cell counts in maintenance hemodialysis patients2010

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      International Meeting of Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reverse epidemiology of circulating Ngal (or lipocalin 2) levels in end-stage renal disease2010

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      International Society of Nephrology Nexus Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] The kidney and neutrophil as the sources of an acute kidney injury biomarker Ngal2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Society of Nephrology Nexus Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Incomplete tubular compensation model for albuminuria in diabetic nephropathy2010

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Society of Nephrology Nexus Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] 末期腎不全における血液中Ngal濃度の逆説的疫学現象2010

    • Author(s)
      今牧博貴、森潔, ほか
    • Organizer
      日本腎臓学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト急性腎障害バイオマーカーNgalの産生部位としての好中球と腎臓2010

    • Author(s)
      森潔, ほか
    • Organizer
      日本腎臓学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病性腎症における糸球体過剰ろ過と尿細管機能不全の統一理論2010

    • Author(s)
      森潔, ほか
    • Organizer
      日本腎臓学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液透析セッションにおける血液中Ngal濃度の変化2010

    • Author(s)
      今牧博貴、森潔, ほか
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液透析患者の血清Ngal濃度と代謝性アシドーシスの関係及び逆説的疫学2010

    • Author(s)
      今牧博貴、森潔, ほか
    • Organizer
      日本内科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of albuminuria in diabetic nephropathy--urinary intact albumin and incomplete tubular compensation model2010

    • Author(s)
      K.Mori, et al
    • Organizer
      日本糖尿病学会学術集会
    • Place of Presentation
      岡山(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性腎臓病(CKD)患者におけるNgalの意義と高血圧の関与の検討2010

    • Author(s)
      川西智子、森潔, ほか
    • Organizer
      日本高血圧学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 尿中バイオマーカーによる急性腎障害、慢性腎臓病の新しい考え方2009

    • Author(s)
      森潔
    • Organizer
      日本臨床化学会近畿支部総会(招待講演)
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿中バイオマーカーによる急性腎障害、慢性腎臓病の新しい考え方2009

    • Author(s)
      森潔
    • Organizer
      日本臨床化学会近畿支部総会(招聘講演)
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Serum Neutrophil Gelatinase-Associated Lipocalin Levels are Determined by Nutritional Status and White Blood Cell Counts but Not by Iron in Maintenance Hemodialysis Patients.2009

    • Author(s)
      H.Imamaki, K.Mori, et al.
    • Organizer
      American Society of Nephrology (ASN).
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Renal Medullary NGAL Is Essential To Suppress Urinary Tract Infection.2009

    • Author(s)
      N.Paragas, K.Mori, et al.
    • Organizer
      American Society of Nephrology (ASN)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Serum Neutrophil Gelatinase-Associated Lipocalin Levels are Determined by Nutritional Status and White Blood Cell Counts but Not by Iron in Maintenance Hemodialysis Patients2009

    • Author(s)
      T.Imamaki, et al.
    • Organizer
      American Society of Nephrology (ASN)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neutrophil Gelatinase-Associated Liocalin as a Novel Urinary Biomarkerof Diabetic Nephropathy and its Response to Angiotensin Receptor Blocker.2009

    • Author(s)
      K.Mori, et al.
    • Organizer
      The Endocrine Society (ENDO).
    • Place of Presentation
      Washington, DC ; USA
    • Year and Date
      2009-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎臓における新規細胞間情報伝達分子の探索と臨床応用2009

    • Author(s)
      森潔
    • Organizer
      日本腎臓学会学術集会(招待講演)
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎臓における新規細胞間情報伝達分子の探索と臨床応用2009

    • Author(s)
      森潔
    • Organizer
      日本腎臓学会学術総会(招聘講演)
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Urinary Excretion of an AKI Biomarker Ngal is Increased in Diabetic Nephropathy by Impaired Tubular Reabsorption, Which Can Be Attenuated by Angiotensin Receptor Blockade.2009

    • Author(s)
      K.Mori, et al.
    • Organizer
      World Congress of Nephrology (WCN).
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Progression of renal lesions after nephron reduction : role of lipocalin 2.2008

    • Author(s)
      A.Viau, K.Mori, et al.
    • Organizer
      American Society of Nephrology (ASN).
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin (Ngal) by angiotensin receptor blockers (ARBs) in diabetic or obese subjects.2008

    • Author(s)
      T.Kuwabara, K.Mori, et al.
    • Organizer
      American Society of Nephrology (ASN).
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin (Ngal) by angiotensin receptor2008

    • Author(s)
      T. Kuwabara, et al.
    • Organizer
      American Society of Nephrology (ASN)
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] siderophore結合蛋白の生物学~分化誘導、組織障害、癌、感染、造血の新しい接点~2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本血液学会学術総会(招聘講演)
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] siderophore結合蛋白の生物学〜分化誘導、組織障害、癌、感染、造血の新しい接点〜2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本血液学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 内分泌因子・液性因子と腎予後予測 -NgalとBNPを中心に-2008

    • Author(s)
      向山政志, ほか
    • Organizer
      日本腎臓学会西部学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons.2008

    • Author(s)
      K.Mori, et al.
    • Organizer
      International Society of Hypertension (ISH).
    • Place of Presentation
      Berlin
    • Year and Date
      2008-06-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons.2008

    • Author(s)
      K. Mori, et al.
    • Organizer
      International Society of Hypertension (ISH)
    • Place of Presentation
      Berlin
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adrenomedullin gene transfer in rat kidney inhibits connective tissue growth factor, extracellular signal-regulated kinase, and renal fibrosis.2008

    • Author(s)
      T.Nagae, K.Mori, et al.
    • Organizer
      The Endocrine Society (ENDO).
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Adrenomedullin gene transfer in rat kidney inhibits connective tissue growth factor, extracellular signal-regulated kinase, and renal fibrosis.2008

    • Author(s)
      T. Nagae, et al.
    • Organizer
      The Endocrine Society (ENDO)
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 尿中Ngal濃度の解析から考えられる理想の腎障害マーカー像:Kidney Biomarkerology.2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本腎臓学会学術集会(招聘講演)
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿中Ngal濃度の解析から考えられる理想の腎障害マーカー像(Kidney Biomarkerology 2008).2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1型及び2型糖尿病に伴う糖尿病性腎症モデルマウスの糸球体における遺伝子発現変動パターンの網羅的解析2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] ネフローゼ治療中の血中・尿中Neutrophil gelatinase-associated lipocalin (Ngal)濃度の推移2008

    • Author(s)
      桑原孝成, ほか
    • Organizer
      日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice.2008

    • Author(s)
      K.Mori, et al.
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy.
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2008-03-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice.2008

    • Author(s)
      K. Mori, et al.
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2008-03-20
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/kidney.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/kidney.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/kidney.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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