Gene expression profile of tonsils of patients with IgA nephropathy
Project/Area Number |
20590957
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Osaka University |
Principal Investigator |
IMAI Enyu Osaka University, 大学院・医学系研究科, 特任准教授 (00223305)
|
Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Yasuyuki 大阪大学, 大学院・医学系研究科, 助教 (10379167)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | IgA腎症 / マイクロアレイ / APOBEC2 / 遺伝子解析 / 腎臓内科学 / IA腎症 / 腎臓 / 扁桃腺 / 腎臟内科学 |
Research Abstract |
We analyzed the gene expression in the tonsils of patients with IgA nephropathy (N=23) using microarray, compared with those with patients suffering from chronic tonsillitis without IgAN (N=22). We confirmed12 up-regulated genes including APOBEC2, CALB2, DUSP27, and CXCL11. APOBEC2 was positively stained in the epithelium and the peripheral region of the germinal center. The APOBEC2 was confirmed to be elevated in the tonsils in another 73 IgAN patients. These results suggest that the APOBEC2 might be associated with development of IgAN.
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Report
(4 results)
Research Products
(136 results)
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Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H, Isaka Y, Hayashi T
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[Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism Research to Distinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN)2009
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[Journal Article] Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure2009
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Bone. 44(4)
Pages: 678-683
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[Journal Article] Fully phosphorylated fetuin-A forms a mineral complex in the serum ofrats with adenine-induced renal failure.2009
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[Journal Article] Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PT Hand bone mineral density in non-diabetic predialysis CKD patients.2009
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[Journal Article] Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease : addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor andangiotensin II receptor blocker.2008
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