Carbamylated erythropoietin (CEPO) and Tempol inhibits cerebral oxidative stress and improves spatial memory dysfunction in experimental uremic mice

• Project/Area Number: 20590959
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kyushu University
• Principal Investigator: TSURUYA Gazuhiko Kyushu University, 医学研究院, 寄付講座教員 (20372740)
• Co-Investigator(Kenkyū-buntansha): TANIGUCHI Masatomo 九州大学, 医学研究院病態機能内科学, 助教 (60419562) ; NAKANO Toshiaki 九州大学, 大学病院腎疾患治療部, 助教 (10432931) ; 升谷 耕介 九州大学, 大学病院, 助教 (30419593)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性腎不全 / 尿毒症性脳症 / 酸化ストレス / 尿毒症性脳障害 / 腎臓学 / 神経学

Research Abstract

The present study provides evidence that Carbamylated erythropoietin (CEPO) and Tempol (TMP) significantly improve uremia-induced cognitive dysfunction。 In addition, the results suggest that CEPO and TMP may be useful in treating cognitive dysfunction associated with CKD

Research Products

• [Presentation] 慢性腎不全における脳内酸化ストレスと記憶障害の検討
  • Author(s): 藤崎毅一郎, 鶴屋和彦, 大和真由実, 内海英雄, 飯田三雄
  • Organizer: 第51回日本腎臓学会学術総会
• [Presentation] American Society of Nephrology Renal Week 2008 Annual Meeting and Scientific Exposition Carbamylerythropoietin (CEPO) inhibits cerebral oxidative stress and improves spatial memory dysfunction in experimental uremic mice
  • Author(s): Kiichiro Fujisaki, Kazuhiko Tsuruya, Mayumi Yamato, Masatomo Taniguchi, Kohsuke Masutani, Hideo Utsumi, Mitsuo Iida
• [Presentation] 尿毒症性脳障害におけるカルバミル化エリスロポエチン(CEPO)の脳保護効果
  • Author(s): 藤崎毅一郎, 鶴屋和彦, 大和真由実, 内海英雄, 飯田三雄
  • Organizer: 第52回日本腎臓学会学術総会
• [Presentation] American Society of Nephrology Renal Week 2009 Annual Meeting and Scientific Exposition Neuroprotective effect of tempol, a membranepermeable radical scavenger, in a mouse uremic memory dysfunction model
  • Author(s): Kiichiro Fujisaki, Kazuhiko Tsuruya K, Mayumi Yamato, Masatomo Taniguchi, Kousuke Masutani, Hideo Utsumi, Mitsuo Iida
• [Presentation] 尿毒症性脳障害における抗酸化薬Tempol (TMP)の脳保護効果
  • Author(s): 藤崎毅一郎, 鶴屋和彦, 大和真由実
  • Organizer: 第53回日本腎臓学会学術総会
• [Remarks] ホームページ等:なし