Carbamylated erythropoietin (CEPO) and Tempol inhibits cerebral oxidative stress and improves spatial memory dysfunction in experimental uremic mice
| Project/Area Number |
20590959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
TSURUYA Gazuhiko Kyushu University, 医学研究院, 寄付講座教員 (20372740)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Masatomo 九州大学, 医学研究院病態機能内科学, 助教 (60419562)
NAKANO Toshiaki 九州大学, 大学病院腎疾患治療部, 助教 (10432931)
升谷 耕介 九州大学, 大学病院, 助教 (30419593)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性腎不全 / 尿毒症性脳症 / 酸化ストレス / 尿毒症性脳障害 / 腎臓学 / 神経学 |
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| Research Abstract |
The present study provides evidence that Carbamylated erythropoietin (CEPO) and Tempol (TMP) significantly improve uremia-induced cognitive dysfunction。 In addition, the results suggest that CEPO and TMP may be useful in treating cognitive dysfunction associated with CKD
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Report
(4 results)
Research Products
(6 results)
