• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The study on the molecular relationships between TRPC6, NFκB, and NFAT in the progress of chronic kidney diseases

Research Project

Project/Area Number 20590961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKeio University

Principal Investigator

HAYASHI Matsuhiko  Keio University, 医学部, 教授 (60129608)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords慢性腎臓病 / NFκB / NFAT / TRPC6
Research Abstract

To reveal the mechanisms of progression of chronic kidney diseases, the roles of TRPC6, which was reported to be a causative gene for one type of congenital focal segmental sclerosis and related some forms of renal diseases, and NFAT and NFκB, TRPC6-related signal transduction protein, were examined in the rat models of renal diseases. The inhibitor of NFκB ameliorated renal impairment by aldosterone, which is recently reported to play a role in the renal injury of chronic kidney diseases, whereas TRPC6 and NFAT did not show significant changes. In the present study, it was suggested that NFκB activation plays important roles in certain types of kidney diseases and its inhibitor may be a candidate for the treatment of chronic kidney disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Aldosterone-induced kidney injury is mediated by NFκB activation.2011

    • Author(s)
      Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M
    • Journal Title

      Clincal & Experimental Nephrology 15

      Pages: 41-49

    • NAID

      10029004386

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-induced kidney injury is mediated by NFκB activation.2011

    • Author(s)
      Fukuda S, Horimai C,Harada K, Wakamatsu T,Fukasawa H, Muto S, Itai A,Hayashi M.
    • Journal Title

      Clinical & Experimental Nephrology

      Volume: 15 Pages: 41-49

    • NAID

      10029004386

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp 130-signaling cytokines in rodents.2010

    • Author(s)
      Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M, Kawakami T, Kimura T, Monkawa T, Hayashi M, Iwanami A, Okano H, Okada Y, Ishibashi-Ueda H, Ogawa S, Fukuda K.
    • Journal Title

      Journal of the Clinical Investigation 120

      Pages: 408-421

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design.2009

    • Author(s)
      Eguchi T, Maruyama T, Ohno Y, Morii T, Hirao K, Hirose H, Kawabe H, Saito I, Hayashi M, Saruta T.
    • Journal Title

      Hypertension Research 32

      Pages: 775-779

    • NAID

      10026123147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis.2008

    • Author(s)
      Takase 0, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ.
    • Journal Title

      Kidney International 73

      Pages: 567-577

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-κB-dependent genes induced by proteinuria and identified using DNA microarrays.2008

    • Author(s)
      Takase 0, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M.
    • Journal Title

      Clinical and Exp erimental Nephrol ogy 12

      Pages: 181-188

    • NAID

      10024141137

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腎内アンジオテンシン変換酵素2型(ACE2)はアルドステロンにより抑制される2010

    • Author(s)
      林松彦、堀米ちひろ、福田誠一、原田香織、柳瀬健志、深澤弘志、武藤進、板井昭子
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Angiotensin-converting enzyme 2 and clusterin are regulated by aldosterone in the kidney.2009

    • Author(s)
      Hayashi M, Horimai C, Fukuda S, Saito N, Yanase T, Fukasawa H, Muto S, Itai A
    • Organizer
      The 42th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Angiotensin-converting enzyme 2 and clusterin are regulated by aldosterone in the kidney.2009

    • Author(s)
      Hayashi M, Horimai C, Fukuda S, Saito N, Yanase T, Fukasawa H, Muto S, Itai A
    • Organizer
      the 42th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] NFkBの関与は心臓と腎臓では異なる2009

    • Author(s)
      林松彦、門川俊明、堀米ちひろ、西東規子、柳瀬健志、深澤弘志、武藤進、板井昭子
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] NFκB activation is involved in aldosterone-induced tissue injuryin the kidney but not in the heart.2008

    • Author(s)
      Hayashi M, Fukuda S, Monkawa T, Saito N, Yanase T, Fukasawa H, Muto S, Itai A, Shimoda K
    • Organizer
      The 41th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] NFκB activation is involved in aldosterone-induced tissue injury in the kidney but not in the heart.2008

    • Author(s)
      Hayashi M, Fukuda S, Monkawa T, Saito N, Yanase T, Fukasawa H, Muto S, Itai A, Shimoda K
    • Organizer
      the 41th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 核転写因子NF-κBを中心とした炎症進展と細胞死の相互作用の解明2008

    • Author(s)
      高瀬敦、菱川慶一、林松彦、Richard Quigg、藤田敏郎
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2008-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] アルドステロンの組織障害はNF, κBを介する2008

    • Author(s)
      林松彦, 福田誠一, 西東規子, 柳瀬健志, 深潭弘志, 武藤進, 板井昭子
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi