The study on the molecular relationships between TRPC6, NFκB, and NFAT in the progress of chronic kidney diseases
| Project/Area Number |
20590961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
HAYASHI Matsuhiko Keio University, 医学部, 教授 (60129608)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性腎臓病 / NFκB / NFAT / TRPC6 |
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| Research Abstract |
To reveal the mechanisms of progression of chronic kidney diseases, the roles of TRPC6, which was reported to be a causative gene for one type of congenital focal segmental sclerosis and related some forms of renal diseases, and NFAT and NFκB, TRPC6-related signal transduction protein, were examined in the rat models of renal diseases. The inhibitor of NFκB ameliorated renal impairment by aldosterone, which is recently reported to play a role in the renal injury of chronic kidney diseases, whereas TRPC6 and NFAT did not show significant changes. In the present study, it was suggested that NFκB activation plays important roles in certain types of kidney diseases and its inhibitor may be a candidate for the treatment of chronic kidney disease.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp 130-signaling cytokines in rodents.2010
Author(s)
Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M, Kawakami T, Kimura T, Monkawa T, Hayashi M, Iwanami A, Okano H, Okada Y, Ishibashi-Ueda H, Ogawa S, Fukuda K.
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Journal Title
Journal of the Clinical Investigation 120
Pages: 408-421
Related Report
Peer Reviewed
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