| Project/Area Number |
20590963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
|
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| Research Institution | Juntendo University |
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Principal Investigator |
SUZUKI Yusuke Juntendo University, 医学部, 准教授 (70372935)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINO Yaqsuhiko 順天堂大学, 医学部, 教授 (60130077)
HORIKOSHI Satoshi 順天堂大学, 医学部, 先任准教授 (80260884)
KIHARA Masao 順天堂大学, 医学部, 助教 (50512604)
SUZUKI Hitoshi 順天堂大学, 医学部, 助教 (10468572)
NAKATA Junichiro 順天堂大学, 医学部, 助教 (20365638)
YAMAJI Kenji 順天堂大学, 医学部, 助手 (90420835)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | IgA腎症 / 樹状細胞 / 粘膜免疫 / ddYマウス / TLR9 / CD11c / CDllc |
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| Research Abstract |
The present study demonstrated that mucosal activation of TLR9 on B cells and DC had different contributions to the progression of murine IgAN, presumably via formation of nephritogenic IgA and IgA-IgG IC, respectively.
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