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Potential roles of dendritic cells in murine IgA nephropathy

Research Project

Project/Area Number 20590963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionJuntendo University

Principal Investigator

SUZUKI Yusuke  Juntendo University, 医学部, 准教授 (70372935)

Co-Investigator(Kenkyū-buntansha) TOMINO Yaqsuhiko  順天堂大学, 医学部, 教授 (60130077)
HORIKOSHI Satoshi  順天堂大学, 医学部, 先任准教授 (80260884)
KIHARA Masao  順天堂大学, 医学部, 助教 (50512604)
SUZUKI Hitoshi  順天堂大学, 医学部, 助教 (10468572)
NAKATA Junichiro  順天堂大学, 医学部, 助教 (20365638)
YAMAJI Kenji  順天堂大学, 医学部, 助手 (90420835)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsIgA腎症 / 樹状細胞 / 粘膜免疫 / ddYマウス / TLR9 / CD11c / CDllc
Research Abstract

The present study demonstrated that mucosal activation of TLR9 on B cells and DC had different contributions to the progression of murine IgAN, presumably via formation of nephritogenic IgA and IgA-IgG IC, respectively.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results) Presentation (11 results)

  • [Journal Article] IgA腎症の病態における扁桃B細胞の役割2011

    • Author(s)
      鈴木祐介
    • Journal Title

      医学のあゆみ 236

      Pages: 1193-1194

    • NAID

      130005438086

    • Related Report
      2010 Final Research Report
  • [Journal Article] IgA腎症とHenoch-Schonlein紫斑病2011

    • Author(s)
      鈴木祐介
    • Journal Title

      腎と透析 70

      Pages: 73-76

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reevaluation of Mucosa-Bone Marrow-Axis in IgA nephropathy with animal models.2011

    • Author(s)
      Yusuke Suzuki, 他
    • Journal Title

      ADVANCES IN OTO-RHINO-LARYNGOLOG

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Glycosylation of IgA1 and Anti-Glycan Antibodies in IgA Nephropathy : Role of Mucosal Immune System.2011

    • Author(s)
      Jan Novak, Yusuke Suzuki, 他
    • Journal Title

      ADVANCES IN OTO-RHINO-LARYNGOLOG

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgA腎症の病態における扁桃B細胞の役割2011

    • Author(s)
      鈴木祐介
    • Journal Title

      医学のあゆみ

      Volume: 236 Pages: 1193-1194

    • NAID

      130005438086

    • Related Report
      2010 Annual Research Report
  • [Journal Article] IgA腎症とHenoch-Schonlein紫斑病2011

    • Author(s)
      鈴木祐介, 他
    • Journal Title

      腎と透析

      Volume: 70 Pages: 73-76

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Clinicoepidemiological manifestations of RPGN and ANCA-associated vasculitides : an 11-year retrospective hospital-based study in Japan.2010

    • Author(s)
      鈴木祐介, et al.
    • Journal Title

      Mod Rheumatol. 20

      Pages: 54-62

    • NAID

      10027168386

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of core 1{beta}1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1.2010

    • Author(s)
      Koshi Yamada, Yusuke Suzuki, et al.
    • Journal Title

      Nephrol Dial Transplant. 25

      Pages: 3890-3897

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicoepidemiological manifestations of RPGN and ANCA-associated vasculitides : an 11-year retrospective hospital-based study in Japan2010

    • Author(s)
      Yusuke Suzuki, 他
    • Journal Title

      Mod Rheumatol.

      Volume: 20 Pages: 54-62

    • NAID

      10027168386

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of core 1 {beta}1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1.2010

    • Author(s)
      Koshi Yamada, Yusuke Suzuki, 他
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 25 Pages: 3890-3897

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of tubular liver-type fatty acid binding protein in murine IgA nephropathy.2010

    • Author(s)
      Nan Zuo, Yusuke Suzuki, 他
    • Journal Title

      Nephrol Dial Transplant.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgA腎症-病態の理解と治療の進歩-2010

    • Author(s)
      Yusuke Suzuki, 他
    • Journal Title

      Nephrology Frontier (In press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity2009

    • Author(s)
      Hitoshi Suzuki, Yusuke Suzuki, 他
    • Journal Title

      J Clin Invest 119(6)

      Pages: 1450-2

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of tubular liver-type fatty acid binding protein in murine IgA nephropathy.

    • Author(s)
      Nan Zuo, Yusuke Suzuki, et al.
    • Journal Title

      Nephrol Dial Transplant. (in Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of Mucosa-Bone Marrow-Axis in IgA nephropathy with animal models.

    • Author(s)
      鈴木祐介, et al.
    • Journal Title

      ADVANCES IN OTO-RHINO-LARYNGOLOG. (in Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Glycosylation of IgA1 and Anti-Glycan Antibodies in IgA Nephropathy : Role of Mucosal Immune System.

    • Author(s)
      Jan Novak, Yusuke Suzuki, et al.
    • Journal Title

      ADVANCES IN OTO-RHINO-LARYNGOLOG. (in Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Different Disease phenotypes differ by activation of TLR9 on dendritic cells (DC) and B cells in murine IgA nephropathy.2010

    • Author(s)
      梶山忠弘, 鈴木祐介, et al.
    • Organizer
      American Society of Nephrology Annual meeting 2010
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Different Disease phenotypes differ by activation of TLR9 on dendritic cells (DC) and B cells in murine IgA nephropathy.2010

    • Author(s)
      Tadahiro Kajiyama, Yusuke Suzuki, 他
    • Organizer
      American Society of Nephrology Annual meeting 2010
    • Place of Presentation
      Denver Conference Center
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mucosa-Bone Marrow-Axis in IgA Nephropathy-Insights from Animal Models-2010

    • Author(s)
      鈴木祐介, et al.
    • Organizer
      The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Asahikawa, Japan
    • Year and Date
      2010-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Mucosa-Bone Marrow-Axis in IgA Nephropathy-Insights from Animal Models-2010

    • Author(s)
      Yusuke Suzuki, 他
    • Organizer
      The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Asahikawa Grand Hotel
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Different disease phenotypes by activation of TLR9 on dendritic cells(DC) and B cells in murine IgA nephropathy.2010

    • Author(s)
      梶山忠弘, 鈴木祐介, et al.
    • Organizer
      The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Asahikawa, Japan
    • Year and Date
      2010-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Different disease phenotypes by activation of TLR9 on dendritic cells(DC) and B cells in murine IgA nephropathy.2010

    • Author(s)
      Tadahiro Kajiyama, Yusuke Suzuki, 他
    • Organizer
      The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Asahikawa Grand Hotel
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgA腎症モデルマウスにおける、感作抗原の相違がもたらす病態の多様性の検討2010

    • Author(s)
      梶山忠弘、鈴木祐介, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] IgA腎症モデルマウスにおける、感作抗原の相違がもたらす病態の多様性の検討2010

    • Author(s)
      梶山忠弘, 鈴木祐介, 他
    • Organizer
      第53回 日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgA腎症疾患特異的IgA産生や腎炎の惹起に関わる樹状細胞の同定と機能的役割2010

    • Author(s)
      Tadahiro Kajiyama, 他
    • Organizer
      IgA腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Potential role of mucosal TLR9 activation in murine IgA nephropathy2009

    • Author(s)
      Yusuke Suzuki, 他
    • Organizer
      International Symposium on IgA Nephropathy
    • Place of Presentation
      Stresa(Lago Maggiore), Italy
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Potential role of dendritic cells in murine IgA nephropathy2008

    • Author(s)
      Yusuke Suzuki, 他
    • Organizer
      11^<th> Asian pacific Congress of Nephrology
    • Place of Presentation
      Kuala Lumpur Convention Center
    • Year and Date
      2008-05-06
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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