| Project/Area Number |
20590964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Tatsuo 順天堂大学, 医学部, 教授 (90114488)
ICHIMURA Koichiro 順天堂大学, 医学部, 准教授 (10343485)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 足細胞 / スリット膜 / シグナル伝達 / メサンギウム細胞 / 腎炎 / SIRP / CD47 |
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| Research Abstract |
Renal glomerulus is consisted with endothelial cells, podocytes and mesangial cells. These cells cooperate with each other for glomerular filtration ; however, the intercellular signaling molecules between glomerular cells are not fully determined. We demonstrate that SIRP-α, which recruits a broadly distributed tyrosine dephosphorylase SHP-2 to the plasma membrane, is located in podocytes. CD47, a ligand for SIRP-α, is located along the plasma membrane of mesangial cells, but not on podocytes. CD47 binds to the extracellular domain of SIRP-αa when mesangial cellsa are injured. The data suggest that the CD47-SIRP-α interaction may be functionally important in cell-cell communication in the diseased glomerulus.
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