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Understanding of cross-talk between glomerular cells in health and disease.

Research Project

Project/Area Number 20590964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionJuntendo University

Principal Investigator

KURIHARA Hidetake  順天堂大学, 医学部, 先任准教授 (80311976)

Co-Investigator(Kenkyū-buntansha) SAKAI Tatsuo  順天堂大学, 医学部, 教授 (90114488)
ICHIMURA Koichiro  順天堂大学, 医学部, 准教授 (10343485)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords足細胞 / スリット膜 / シグナル伝達 / メサンギウム細胞 / 腎炎 / SIRP / CD47
Research Abstract

Renal glomerulus is consisted with endothelial cells, podocytes and mesangial cells. These cells cooperate with each other for glomerular filtration ; however, the intercellular signaling molecules between glomerular cells are not fully determined. We demonstrate that SIRP-α, which recruits a broadly distributed tyrosine dephosphorylase SHP-2 to the plasma membrane, is located in podocytes. CD47, a ligand for SIRP-α, is located along the plasma membrane of mesangial cells, but not on podocytes. CD47 binds to the extracellular domain of SIRP-αa when mesangial cellsa are injured. The data suggest that the CD47-SIRP-α interaction may be functionally important in cell-cell communication in the diseased glomerulus.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (95 results)

All 2012 2011 2010 2009 2008

All Journal Article (39 results) (of which Peer Reviewed: 39 results) Presentation (43 results) Book (11 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Roles of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis of renal proximal tubular epithelial cells2012

    • Author(s)
      Withanage Kanchanamala, Nakagawa K, Ikeda M, Kurihara H, Kudo T, Yang Z, Sakane A, Sasaki T, Hata Y
    • Journal Title

      J Biochem

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of broad distribution of electron-dense deposits in patients with IgA nephropathy2012

    • Author(s)
      Kusaba G, Ohsawa I, Ishii M, Inoshita H, Takagi M, Tanifuji C, Takahashi K, Nakamoto J, Yoshida M, Ohi H, Horikoshi S, Kurihara H, Tomino Y
    • Journal Title

      Med Mol Morphol

      Volume: 45(1) Pages: 29-34

    • NAID

      10030573625

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of connexin43 dephosphorylation is involved in protective effects of diltiazem on cardiac function during hypoxic injury2011

    • Author(s)
      Matsushita S, Kurihara H, Watanabe M, Okada T, Sakai T, Amano A
    • Journal Title

      Histol Histopathol

      Volume: 26 Pages: 315-322

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis2011

    • Author(s)
      Ning L, et al
    • Journal Title

      Int Orthop

      Volume: 35 Issue: 6 Pages: 831-838

    • DOI

      10.1007/s00264-010-1045-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis2010

    • Author(s)
      Kaufman L, Porla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D' Agati VD, Klotman PE
    • Journal Title

      J Biol Chem

      Volume: 285(33) Pages: 25677-25685

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in renal glomerulus2010

    • Author(s)
      Kurihara H, Harita Y, Ichimura K, Hattori S, Sakai T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299(3)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary cila disappear in rat podocytes during glomerular development2010

    • Author(s)
      Ichimura K, Kurihara H, Sakai T
    • Journal Title

      Cell Tissue Res

      Volume: 341 Pages: 197-209

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid multiple immunocytochemical staining method using microwave irradiation for intraoperative cytology2010

    • Author(s)
      Furuhata A, Sueyoshi N, Kurihara H, Sakamoto K, Kamano T, Hino O
    • Journal Title

      Acta Cytol

      Volume: 54(3) Pages: 283-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in renal glomerulus.2010

    • Author(s)
      Kurihara H, Harita Y, Ichimura K, Hattori S, Sakai T
    • Journal Title

      Am J Physiol Renal Physiol 299(3)

      Pages: 517-527

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in renal glomerulus.2010

    • Author(s)
      Kurihara H, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary cila disappear in rat podocytes during glomerular development.2010

    • Author(s)
      Ichimura, et al.
    • Journal Title

      Cell Tissue Res

      Volume: 341 Pages: 197-209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis.2010

    • Author(s)
      Kaufman L, et al.
    • Journal Title

      J Biol Chem

      Volume: 285(33) Pages: 25677-25685

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-cytoplasmic actin localization in vertebrate glomerular podocytes2009

    • Author(s)
      Ichimura K, Kurihara H, Sakai T
    • Journal Title

      Arch Histol Cytol

      Volume: 72(3) Pages: 165-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis2009

    • Author(s)
      Qin X-S, Tsukaguchi H, Shono A, Yamamoto A, Kurihara H, Doi T
    • Journal Title

      J Am Soc Nephrol

      Volume: 20(12) Pages: 2534-2545

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cortactin interacts with podocalyxin and mediates morphological change of podocyte through its phosphorylation2009

    • Author(s)
      Kobayashi T, Notoya M, Shinosaki T, Kurihara H
    • Journal Title

      Nephron Exp Nephrol

      Volume: 113

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The CXCL12(SDF-1)/CXCR4 axis is essential for the development of rRenal vasculature2009

    • Author(s)
      Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, IsakaY
    • Journal Title

      J Am Soc Nephrol

      Volume: 20 Pages: 1714-1723

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of nephrin triggers Ca2+signaling by recruitment and activation of phospholipase c-gamma12009

    • Author(s)
      Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S
    • Journal Title

      J Biol Chem

      Volume: 284(13) Pages: 8951-8962

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of ganglioside GM1 clustering in Laminin-1 induced neurite outgrowth signaling in PC12 cell and DRG neuron2009

    • Author(s)
      Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E
    • Journal Title

      J Cell Sci

      Volume: 122 Pages: 289-299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms2009

    • Author(s)
      Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
    • Journal Title

      PLoS ONE

      Volume: 4(1)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cortactin interacts with podocalyxin and mediates morphological change of podocyte through its phosphorylation.2009

    • Author(s)
      Kobayashi T, Notoya M, Shinosaki T, Kurihara H
    • Journal Title

      Nephron Exp Nephrol 113

      Pages: 89-96

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase c-gamma1.2009

    • Author(s)
      Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S
    • Journal Title

      J Biol Chem 284(13)

      Pages: 8951-8962

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms2009

    • Author(s)
      Hirose T, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of ganglioside GM1 clustering in Laminin-1 induced neurite outgrowth signaling in PC12 cell and DRG neuron2009

    • Author(s)
      Ichikawa N, et al.
    • Journal Title

      J Cell Sci 122

      Pages: 289-299

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase c-gamma12009

    • Author(s)
      Harita Y., et al.
    • Journal Title

      J Biol Chem 284

      Pages: 8951-8962

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The CXCL12(SDF-1)/CXCR4 axis is essential for the development of rRenal vasculature2009

    • Author(s)
      Takabatake Y, et al.
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 1714-1723

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortactin interacts with podocalyxin and mediates morphological change of podocyte through its phosphorylation2009

    • Author(s)
      Kobayashi T, et al.
    • Journal Title

      Nephron Exp Nephrol 113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis2009

    • Author(s)
      Qin X-S, et al.
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 2534-2545

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of mineralocorticoid receptor function byRac1 GTPase : implication in proteinuric kidney disease2008

    • Author(s)
      Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T
    • Journal Title

      Nat Med

      Volume: 14 Pages: 1370-1376

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial extrusion through the cytoplasmic vacuoles during cell death2008

    • Author(s)
      Nakajima A, Kurihara H, Yagita H, Okumura K, Nakano H
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 24128-24135

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant cell-to-cell coupling in Ca2+-overloaded guinea pig ventricular muscles2008

    • Author(s)
      Kurebayashi N, Nishizawa H, Nakazato Y, Kurihara H, Matsushita S, Daida H, Ogawa Y
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 294(6)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular endothelial cells form diaphragms during development and pathologic conditions2008

    • Author(s)
      Ichimura K, Stan RV, Kurihara H, Sakai T
    • Journal Title

      J Am Soc Nephrol

      Volume: 19 Pages: 1463-1471

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine Phospho-rylation of the kidney slit diaphragm component Neph1 and its modulation of intracellular signaling by binding with Grb22008

    • Author(s)
      Harita Y, Kurihara H, Kosaka H, Sekine T, Igarashi T, Hattori S
    • Journal Title

      J Biol Chem

      Volume: 283(14) Pages: 9177-9186

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils2008

    • Author(s)
      Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa1 H, Nagaoka I
    • Journal Title

      Glycoconj J

      Volume: 25(4) Pages: 357-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine phosphorylation of the kidney slit diaphragm component Neph1 and its modulation of intracellular signaling by binding with Grb2.2008

    • Author(s)
      Harita Y, Kurihara H, Kosaka H, Sekine T, Igarashi T, Hattori S
    • Journal Title

      J Biol Chem 283(14)

      Pages: 9177-9186

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Glomerular endothelial cells form diaphragms during development and pathologic conditions.2008

    • Author(s)
      Ichimura K, Stan RV, Kurihara H, Sakai T
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 1463-1471

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Tyrosine Phosphorylation of the kidney slit diaphragm component Nephl and its modulation of intracellular sign aling by binding with Grb2.2008

    • Author(s)
      Harita Y., et al.
    • Journal Title

      J Biol Chem 283

      Pages: 9177-9186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular endothelial cells form diaphragms during development and pathologic conditions.2008

    • Author(s)
      Ichimura K., et al.
    • Journal Title

      J Amer Soc Nephrol

      Pages: 1463-1471

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial extrusion through the cytoplasmic vacuoles during cell death.2008

    • Author(s)
      Nakajima A., et al.
    • Journal Title

      J Biol Chem 283

      Pages: 24128-24135

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of mineralocorticoid receptor function by Racl GTPase : implication in proteinuric kidney disease.2008

    • Author(s)
      Shibata s., et al.
    • Journal Title

      Nat Med 14

      Pages: 1370-1376

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糸球体足細胞におけるmyosinIIAの局在とその機能的意義について、ポスター2012

    • Author(s)
      脇田春彦、西尾亮太、栗原秀剛、坂井建雄
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] スリット膜のターンオーバー制御を担う分子機構の解明: aPKC-Par複合体を介したnephrinの細胞膜局在制御、口演2011

    • Author(s)
      佐藤大輔、張田豊、大門主税、栗原秀剛、廣瀬智威、大野茂雄
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression of primary cilia in rat mesangial cells2011

    • Author(s)
      Ichimura K, Kurihara H, Sakai T
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] スリット膜構成蛋白の分子動態2011

    • Author(s)
      栗原秀剛
    • Organizer
      第6回弥彦ポドサイトセミナー
    • Place of Presentation
      新潟
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] 家族制パーキンソン病原因遺伝子; ATP13A2遺伝子発現抑制は神経細胞死を引き起こす、ポスター2010

    • Author(s)
      里史明、船山学、佐藤栄人、斉木臣二、栗原秀剛、服部信孝
    • Organizer
      第33回日本分子生物学会年会および第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Nonmuscle myosin heavy chain IIA encoded by MYH9 is localized in the primary processes of podocytes and its expression is significantly decreased in human FSGS2010

    • Author(s)
      Miura K, Kurihara H, Chikamoto H, Hattori M, Sasaki S, Igarashi T, Sekine T
    • Organizer
      American Society of Nephrology Renal week 2010
    • Place of Presentation
      Denver
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Nonmuscle myosin heavy chain IIA encoded by MYH9 is localized in the primary processes of podocytes and its expression is significantly decreased in human FSGS.2010

    • Author(s)
      Miura K., et al.
    • Organizer
      American Society of Nephrology Renal week 2010
    • Place of Presentation
      Denver
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] The disruption of LacCer-enriched membrane microdomains-mediated signaling by pathogenic mycobacteria2010

    • Author(s)
      Nakayama H, Kurihara H, Prinetti A, Sonnino S, Masuda H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K
    • Organizer
      The 25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Chiba
    • Year and Date
      2010-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞におけるスリット膜の分子構築について、口演2010

    • Author(s)
      栗原秀剛、坂井建雄
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規スリット膜構成分子SIRP-alphaはNephrinと結合し、そのリン酸化を負に制御する、口演2010

    • Author(s)
      張田豊、松長敦子、鶴見晴子、神田祥一郎、栗原秀剛、関根孝司、五十嵐隆、服部成介
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞におけるスリット膜の分子構築について2010

    • Author(s)
      栗原秀剛、坂井建雄
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] 新規スリット膜構成分子SIRP-alphaはNephrinと結合し、そのリン酸化を負に制御する2010

    • Author(s)
      張田豊, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] メサンギウム細胞における一次線毛の存在~連続超薄切片法による検討~、ポスター2010

    • Author(s)
      市村浩一郎、栗原秀剛、坂井建雄
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 免疫組織染色によるMYH9と蛋白尿発症との関連性についての検討2010

    • Author(s)
      三浦健一郎、関根孝司、掘田茂、近本裕子、服部元史、國島伸治、栗原秀剛、佐々木聡、五十嵐隆
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] メサンギウム細胞における一次線毛の存在~連続超薄切片法による検討~2010

    • Author(s)
      市村浩一郎, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糸球体足細胞におけるスリット膜構造の成立について、口演2010

    • Author(s)
      栗原秀剛
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞におけるスリット膜構造の成立について2010

    • Author(s)
      栗原秀剛
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 傷害糸球体の修復過程~Thy1腎炎モデルを用いた解析~2010

    • Author(s)
      市村浩一郎, 他
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] SIRP-alpha-CD47 system functions as an emergency signal in renal glomerulus2009

    • Author(s)
      Kurihara H, Ichimura K, Sakai T
    • Organizer
      49th Annual Meeting of the American Society of Cell Biology
    • Place of Presentation
      San Diego
    • Year and Date
      2009-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] SIRP-alpha-CD47 system functions as an emergency signal in renal glomerulus.2009

    • Author(s)
      Kurihara H, Ichimura K, Sakai T
    • Organizer
      49th Annual Meeting of the American Society of Cell Biology
    • Place of Presentation
      San Diego
    • Year and Date
      2009-12-06
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] SIRP-alpha-CD47 system functions as an emergency signal in renal glomerulus2009

    • Author(s)
      栗原秀剛
    • Organizer
      49th Annual Meeting of the American Society of Cell Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Upregulation of the Homophilic Adhesion Molecule Sidekick-1 in Podocytes Contributes to Glomerulosclerosis2009

    • Author(s)
      Kaufman L, Potla U, Hata Y, Kurihara H, He JC, D' Agati VD, Klotman PE
    • Organizer
      American Society of Nephrology Renal week 2009
    • Place of Presentation
      San Diego
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Upregulation of the Homophilic Adhesion Molecule Sidekick-1 in Podocytes Contributes to Glomerulosclerosis2009

    • Author(s)
      Kaufman L, et al.
    • Organizer
      American Society of Nephrology Renal week 2009
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] SIRP-αCo-Localizes with Nephrin at the Podocyte Slit Diaphragm, and Modulates Nephrin Tyrosine Phosphorylation2009

    • Author(s)
      Harita Y, Matsunaga A, Tsurumi H, Kanda S, Sekine T, Igarashi T, Hattori S, Kurihara H
    • Organizer
      American Society of Nephrology Renal week 2008
    • Place of Presentation
      San Diego
    • Year and Date
      2009-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] SIRP-α Co-Localizes with Nephrin at the Podocyte Slit Diaphragm, and Modulates Nephrin Tyrosine Phosphorylation2009

    • Author(s)
      Harita Y, et al.
    • Organizer
      American Society of Nephrology Renal week 2009
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] SIRP-α-CD47系の腎糸球体における発現2009

    • Author(s)
      栗原秀剛
    • Organizer
      第40回日本臨床分子形態学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] SIRP-α-CD47 系の腎糸球体における発現2009

    • Author(s)
      栗原秀剛
    • Organizer
      第40回日本臨床分子形態学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-05
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] スリット膜の分子解剖学2009

    • Author(s)
      栗原秀剛
    • Organizer
      第24回 新潟腎シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糸球体足細胞における1次線毛の消失2009

    • Author(s)
      市村浩一郎、栗原秀剛、坂井建雄
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎糸球体ポドサイトのスリット膜維持の新しい分子機構:細胞極性制御系aPKC-PAR系の役割2009

    • Author(s)
      廣瀬智威、佐藤大輔、栗原秀剛、日下智保、廣瀬博子、秋本和憲、松阪泰二、市川家國、伊藤秀一、野田哲生、大野茂雄
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Nephrinのチロシンリン酸化はPLC-γ1を介し細胞内Ca2+濃度を上昇させる2009

    • Author(s)
      張田豊、栗原秀剛、関根孝司、五十嵐隆、大澤郁朗、太田成男、服部成介
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞における1次線毛の消失2009

    • Author(s)
      市村浩一郎、栗原秀剛、坂井建雄
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] The cell polarity protein, aPKCλ, plays a critical role on the maintenance of podocyte slit diaphragm.2008

    • Author(s)
      Hirose T., et al.
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recruitment and activation of PLC-gamma by phosphorylation of nephrin : a new insight into a link between slit diaphragm and calcium signaling.2008

    • Author(s)
      Harita Y., et al.
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] SIRP-alpha-CD47 system functions as an emergency signal in renal glomerulus2008

    • Author(s)
      Kurihara H, Harita Y, Ichimura K, Hattori S, Sakai T
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Recruitment and activation of PLC-gamma by phosphorylation of nephrin : a new insight into a link between slit diaphragm and calcium signaling2008

    • Author(s)
      Harita Y, Kurihara H, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The cell polarity protein, aPKCλ, plays a critical role on the maintenance of podocyte slit diaphragm2008

    • Author(s)
      Hirose T, Sato D, Kurihara H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] SIRP-alpha-CD47 system functions as an emergency signal in renal glomerulus.2008

    • Author(s)
      Kurihara H., et al.
    • Organizer
      The 7th International Podocyte Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ケモカインSDF-1およびその受容体CXCR4の腎血管形成における役割2008

    • Author(s)
      高畠義嗣、猪阪善隆、杉山立樹、栗原秀剛、松阪泰二、長澤丘司
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 足細胞の微絨毛形成に関わる分子群の解析2008

    • Author(s)
      栗原秀剛、市村浩一郎、坂井建雄
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-30
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 糸球体足細胞におけるアクチンアイソフォームの局在様式2008

    • Author(s)
      市村浩一郎、栗原秀剛、坂井建雄
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞における微絨毛形成に関わる分子群の解析2008

    • Author(s)
      栗原秀剛、市村浩一郎、坂井建雄
    • Organizer
      第113回日本解剖学会総会・全国学術集会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体足細胞におけるアクチンアイソフォームの局在様式2008

    • Author(s)
      市村浩一郎、栗原秀剛、坂井建雄
    • Organizer
      第113回日本解剖学会総会・全国学術集会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-27
    • Related Report
      2011 Final Research Report
  • [Book] 腎の解剖学的特性-overview、所収:日本小児腎臓病学会編「小児腎臓病学」2012

    • Author(s)
      栗原秀剛
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 小児腎臓病学2012

    • Author(s)
      栗原秀剛
    • Total Pages
      460
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report
  • [Book] 腎糸球体足細胞スリット膜の分子解剖学、所収:日本臨床分子形態学会編「病気の分子形態学」2011

    • Author(s)
      栗原秀剛
    • Publisher
      学際企画
    • Related Report
      2011 Final Research Report
  • [Book] 泌尿器系、所収:坂井建雄、川上速人監訳「ジュンケイラ組織学」第3版2011

    • Author(s)
      栗原秀剛
    • Publisher
      丸善
    • Related Report
      2011 Final Research Report
  • [Book] 「ジュンケイラ組織学」第3版2011

    • Author(s)
      栗原秀剛
    • Total Pages
      498
    • Publisher
      丸善
    • Related Report
      2011 Annual Research Report
  • [Book] 病気の分子形態学2011

    • Author(s)
      栗原秀剛
    • Total Pages
      370
    • Publisher
      学際企画
    • Related Report
      2011 Annual Research Report
  • [Book] ジュンケイラ組織学(第3版)2011

    • Author(s)
      栗原秀剛
    • Total Pages
      498
    • Publisher
      丸善
    • Related Report
      2010 Self-evaluation Report
  • [Book] ジュンケイラ組織学 第3版2011

    • Author(s)
      栗原秀剛
    • Total Pages
      498
    • Publisher
      丸善
    • Related Report
      2010 Annual Research Report
  • [Book] Cell adhesion molecules in the kidney2011

    • Author(s)
      Kurihara H
    • Total Pages
      48
    • Publisher
      KOKO-DO
    • Related Report
      2010 Annual Research Report
  • [Book] Molecular dissection of slit diaphragm in podocyte, in Cell adhesion molecules in the kidney2010

    • Author(s)
      Kurihara H
    • Related Report
      2011 Final Research Report
  • [Book] Cell adhesion molecules in the kidney.2010

    • Author(s)
      Kurihara H
    • Total Pages
      48
    • Publisher
      KOKO-DO
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 体依存性細胞障害を抑制するモノクローナル抗体2008

    • Inventor(s)
      栗原秀剛、篠崎俊宏、小林樹雄
    • Industrial Property Rights Holder
      塩野義製薬(株)
    • Acquisition Date
      2008-08-29
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 補体依存性細胞障害を抑制するモノクローナル抗体2008

    • Inventor(s)
      栗原秀剛、篠崎俊宏、小林樹雄
    • Industrial Property Rights Holder
      塩野義製薬
    • Acquisition Date
      2008-08-29
    • Related Report
      2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2016-04-21  

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