Regulation of hepcidin expression in renal failure-participation of erythropoiesis related factor-
| Project/Area Number |
20590966
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
TOMOSUGI Naohisa Kanazawa Medical University, 付置研究所, 教授 (80155580)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ヘプシジン-25 / 骨髄造血機能 / 骨髄造血由来因子 |
|---|
| Research Abstract |
In this study, serum hepcidin-25, which is the regulator of the iron-metabolism, has been measured by mass spectrometry, and has became a molecular biomarker of erythropoietic disorders including renal anemia、iron overload and inflammation. The characteristics of iron-metabolism are to recycle iron in the closed system without an active iron-excretion system, and to keep the concentration of the serum iron. This is managed with the feed back mechanism based on the transferring receptor2-hepcidin-ferroportin system.
|
Report
(4 results)
Research Products
(45 results)
-
[Journal Article] Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity than patients with HFE-hemochromatosis.2010
Author(s)
Hayashi H, Piperno A, Tomosugi N, Hayashi K, Kimura F, Wakusawa S, Yano M, Tatsumi Y, Hattori A, Pelucchi S, Katano Y, Goto H.
-
Journal Title
Intern Med. 49(22)
Pages: 2371-7
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.2010
Author(s)
Kaneko Y, Miyajima H, Piperno A, Tomosugi N, Hayashi H, Morotomi N, Tsuchida KI, Ikeda T, Ishikawa A, Ota Y, Wakusawa S, Yoshioka K, Kono S, Pelucchi S, Hattori A, Tatsumi Y, Okada T, Yamagishi M.
-
Journal Title
J Gastroenterol. 45(11)
Pages: 1163-71
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Results of the first international round robin for the quantification of urinary and plasma hepcidin assays : need for standardization.2009
Author(s)
Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW.
-
Journal Title
Haematologica. 94
Pages: 1748-1752
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion.2008
Author(s)
Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, Takeo M, Iwasa M, Kobayashi Y, Hayashi H, Kaito M, Takei Y.
-
Journal Title
J Hepatol. 49(5)
Pages: 702-10
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] TfR2-related hereditary hemochro-matosis in Japan.2009
Author(s)
Mizumoto C, Kanda J, Kawabata H, Uchiyama T, Kojima K, Hayashi T, Hirata M, Nakao K, Tsuchida K, Kawanaka M, Yamada G, Tomosugi N, Tatsumi Y, Hattori A, Hayashi H.
Organizer
2009 International Biolron Society
Place of Presentation
Porto, Portugal
Related Report
-
-
[Presentation] Clinical Significance of Serum Hepcidin-25 Levels on Early Treatment-Related Complications after Hematopoietic Stem Cell Transplantation2008
Author(s)
Junya Kanda, Chisaki Mizumoto, Hiroshi Kawabata, Tatsuo Ichinohe, Hideyuki Tsuchida, Tomosugi N, Keitaro Matsuo, Tadakazu Kondo, Takayuki Ishikawa, Takashi Uchiyama.
Organizer
50^<th> ASH Annual Meeting
Place of Presentation
San Francisco, CA
Related Report
-
[Presentation] Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin : Need for Standardization2008
Author(s)
Joyce JC Kroot, Erwin HJM Kemna, Sukhvinder Bansal, Mark Busbridge, Vatascia Campostrini, Domenico Girelli, Robert C Hider, Vasiliki Koliaraki, Avgi Mamalaki, Gordana Olbina, Naohisa Tomosugi, Chris Tselepis, Douglas G Ward, Tomas Ganz, Jan CM Hendriks, Dorine W. Swinkels.
Organizer
50^<th> ASH Annual Meeting
Place of Presentation
San Francisco, CA
Related Report
-
-
-
[Presentation] C型慢性肝炎にみられる鉄過剰状態へのhepcidinの関与2008
Author(s)
藤田尚己,杉本龍亮,本西哲,田中淳一朗,別府徹也,浦和尚史,田中秀明,山本憲彦,小林由直,岩佐元雄,白木克哉,友杉直久,林久男,竹井謙之
Organizer
第94回日本消化器病学会総会
Place of Presentation
福岡国際会議場
Related Report
-
-
