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Effect of salt load on the intrarenal angiotensin activity and receptor-mediated prorenin system in kidney fibrosis

Research Project

Project/Area Number 20590967
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionHamamatsu University

Principal Investigator

YAMAMOTO Tatsuo  Hamamatsu University, 健康プロデュース学部, 教授 (30200819)

Co-Investigator(Renkei-kenkyūsha) HISHIDA Akira  浜松医科大学, 医学部, 教授 (70111812)
SUZUKI Hiroyuki  浜松医科大学, 医学部, 助教 (10452179)
ISHIDA Junko  浜松大学, 健康プロデュース学部, 助教 (50410501)
ODAMAKI Mari  浜松大学, 健康プロデュース学部, 教授 (00347387)
Research Collaborator HUANG Yanjie  浜松医科大学, 医学部, リサーチアシスタント (30535563)
ISAKI Taro  浜松医科大学, 医学部, リサーチアシスタント (20464125)
OGAWA Akashi  浜松医科大学, 医学部, 医員 (90467225)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsレニン・アンジオテンシン系 / 高塩分 / プロレニン / 腎線維化 / アンジオテンシン / レニン / (プロ)レニン受容体 / 塩分摂取 / 慢性腎臓病 / プロレニン受容体 / 閉塞性腎障害
Research Abstract

Although activation of intrarenal renin angiotensin system (RAS) is involved in the progression of kidney fibrosis, it is unknown how salt load that suppresses circulating RAS aggravates kidney fibrosis. This study demonstrated that high salt intake increased the apical membranous transition of (pro)renin receptor in collecting ducts and connecting tubules, resulting in the increased binding of prorenin and renin proteins without concomitant renin mRNA expression, followed by non-proteolytic activation of prorenin and angiotensin II generation, with resultant worsening of renal fibrosis in chronic anti-thymocyte serum nephritis on high salt intake.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (16 results) Book (2 results)

  • [Journal Article] 塩分負荷と腎組織レニン・アンジオテンシン系2011

    • Author(s)
      山本龍夫
    • Journal Title

      腎と透析 70

      Pages: 293-299

    • Related Report
      2010 Final Research Report
  • [Journal Article] 塩分負荷と腎組織レニン・アンジオテンシン系2011

    • Author(s)
      山本龍夫
    • Journal Title

      腎と透析

      Volume: 70 Pages: 293-299

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats2010

    • Author(s)
      Sullivan JC, Bhatia K, Yamamoto T, Elmarakby AA
    • Journal Title

      Hypertension 56

      Pages: 658-666

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury2010

    • Author(s)
      Schneider M, Sullivan JC, Wach PF, Boesen EI, Yamamoto T, Fukai T, Harrison DG, Pollock DM, Pollock JS
    • Journal Title

      Kidney Int 78

      Pages: 374-381

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of transforming growth factor-β type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma2010

    • Author(s)
      Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Suzuki S, Hayashi H, Ozono S, Kitagawa M, Hishida A
    • Journal Title

      Int.J.Cancer 127

      Pages: 1517-1525

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pentosan Polysulfate Treatment Preserves Renal Autoregulation in Ang II-Infused Hypertensive Rats via Normalization of P2X1 Receptor Activation2010

    • Author(s)
      Guan Z, Fuller BS, Yamamoto T, Cook AK, Pollock JS, Inscho EW
    • Journal Title

      Am.J.Physiol.Renal Physiol. (Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats.2010

    • Author(s)
      Jennifer C.Sullivan
    • Journal Title

      Hypertension

      Volume: 56 Pages: 658-666

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury.2010

    • Author(s)
      Markus P.Schneider
    • Journal Title

      Kidney Int.

      Volume: 78 Pages: 374-381

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentosan polysulfate treatment preserves renal autoregulation in AngII-infused hypertensive rats via normalization of P2X1 receptor activation.2010

    • Author(s)
      Zhengrong Guan
    • Journal Title

      Am.J.Physiol.Renal Physiol.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎とRASオーバービュー -腎障害・高血圧への関与-2010

    • Author(s)
      山本龍夫
    • Journal Title

      日本腎臓学会誌 52

      Pages: 87-91

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Pentosan Polysulfate Treatment Preserves Renal Autoregulation in AngII-Infused Hypertensive Rats via Normalization of P2X1 Receptor Activation2010

    • Author(s)
      Zhengrong Guan
    • Journal Title

      Am J Physiol Renal Physiol (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats2009

    • Author(s)
      Misaki T, Yamamoto T, Suzuki S, Fukasawa H, Togawa A, Ohashi N, Suzuki H, Fujigaki Y, Oda T, Uchida C, Kitagawa K, Hattori T, Kitagawa M, Hishida A
    • Journal Title

      Am.J.Pathol. 175

      Pages: 74-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary angiotensinogen as a potential biomarker of severity of chronic kidneys diseases2008

    • Author(s)
      Kobori H, Ohashi N, Katsurada A, Miyata K, Satou R, Saito T, Yamamoto T
    • Journal Title

      J.Am.Soc.Hypertens 2

      Pages: 349-354

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats2008

    • Author(s)
      Ohashi N, Yamamoto T, Huang Y, Misaki T, Fukasawa F, Suzuki H, Togawa A, Suzuki S, Fujigaki Y, Nakagawa T, Nakamura Y, Suzuki F, Kitagawa M, Hishida A
    • Journal Title

      Am.J.Physiol.Renal Physiol. 295(5)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats.2008

    • Author(s)
      Naro Ohashi
    • Journal Title

      Am. J. Physiol. Renal Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Increases in intrarenal prorenin and renin are mediated by angiotensin II in chronic anti-thymocyte serum (ATS) nephritis rats on high salt intake2010

    • Author(s)
      Huang Y
    • Organizer
      Renal Week 2010, 43nd Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Increases in intrarenal prorenin and renin are mediated by angiotensin II in chronic anti-thymocyte serum (ATS) nephritis rats on high salt intake.2010

    • Author(s)
      Yanjie Huang
    • Organizer
      Renal Week 2010, 43nd Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Rho-kinase (ROCK) and epidermal growth factor receptor (EGFR) activation in glomerular injuries induced by angiotensin II (AngII)-dependent hypertension2010

    • Author(s)
      鈴木洋行
    • Organizer
      Renal Week 2010, 43nd Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Rho-kinase (ROCK) and epidermal growth factor receptor (EGFR) activation in glomerular injuries induced by angiotensin II (AngII)-dependent hypertension.2010

    • Author(s)
      Hiroyuki Suzuki
    • Organizer
      Yenal Week 2010, 43nd Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased intrarenal prorenin and renin are involved in the renal damage in chronic antithymocyte serum (ATS) nephritis rats on high salt intake2010

    • Author(s)
      Huang Y
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Increases in intrarenal prorenin and renia are involved in the renal damage in chronic anti-thymocyte serum (ATS) nephritis rats on high salt intake.2010

    • Author(s)
      Yanjie Huang
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intrarenal prorenin and renin are increased in chronic anti-thymocyte serum (ATS) nephritis rats on high salt intake2010

    • Author(s)
      Yamamoto T
    • Organizer
      International Society of Nephrology NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Intrarenal prorenin and renin are increased in chronic anti-thymocyte serum (ATS) nephritis rats on high salt intake.2010

    • Author(s)
      Tatsuo Yamamoto
    • Organizer
      International Society of Nephrology NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased tubular prorenin and renin in rats with chronic anti-thymocyte serum (ATS) nephritis under high salt intake (HSI)2009

    • Author(s)
      Huang Y
    • Organizer
      Renal Week 2009, 42nd Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased tubular prorenin and renin in rats with chronic anti-thymocyte serum(ATS)nephritis under high salt intake(HSI)2009

    • Author(s)
      Yanjie Huang
    • Organizer
      American Society of Nephrology, Renal Week 2009
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] アンジオテンシンII(AngII)依存性高血圧におけるRho-kinase(ROCK)活性化が腎障害に及ぼす影響2009

    • Author(s)
      鈴木洋行
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Upregulation of intrarenal renin angiotensin system (RAS) in rats with chronic anti-thymocyte serum (ATS) nephritis under high salt intake (HIS)2009

    • Author(s)
      Huang Y
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] アンジオテンシンII(AngII)依存性高血圧におけるRho-kinase(ROCK) 活性化が腎障害に及ぼす影響2009

    • Author(s)
      鈴木洋行
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Upregulation of intrarenal renin angiotensin system(RAS)in rats with chronic anti-thymocyte serum(ATS)nephritis under high salt intake(HIS)2009

    • Author(s)
      Yanjie Huang
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Rho-Kinase (ROCK) Activation in Kidney Injury Induced by AngiotensinII (AngII)-Dependent Hypertension2008

    • Author(s)
      鈴木洋行
    • Organizer
      Renal Week 2008, 41st Annual Meeting and Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Rho-Kinase (ROCK) Activation in Kidney Injury Induced by AngiotensinII (AngII)-Dependent Hypertension.2008

    • Author(s)
      Hiroyuki Suzuki
    • Organizer
      Am. Soc. Nephrol. Renal Week 2008
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Book] 腎障害・高血圧への関与(日本腎臓学会誌特集号 腎とレニン・アンジオテンシン・アルドステロン系、腎とRASオーバービュー)2010

    • Author(s)
      山本龍夫、西山成
    • Publisher
      東京医学社
    • Related Report
      2010 Final Research Report
  • [Book] 日本腎臓学会誌特集号 腎とレニン・アンジオテンシン・アルドステロン系、腎とRASオーバービュー(腎障害・高血圧への関与)2010

    • Author(s)
      山本龍夫
    • Publisher
      東京医学社
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2024-03-07  

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