| Project/Area Number |
20590967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hamamatsu University |
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Principal Investigator |
YAMAMOTO Tatsuo Hamamatsu University, 健康プロデュース学部, 教授 (30200819)
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| Co-Investigator(Renkei-kenkyūsha) |
HISHIDA Akira 浜松医科大学, 医学部, 教授 (70111812)
SUZUKI Hiroyuki 浜松医科大学, 医学部, 助教 (10452179)
ISHIDA Junko 浜松大学, 健康プロデュース学部, 助教 (50410501)
ODAMAKI Mari 浜松大学, 健康プロデュース学部, 教授 (00347387)
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| Research Collaborator |
HUANG Yanjie 浜松医科大学, 医学部, リサーチアシスタント (30535563)
ISAKI Taro 浜松医科大学, 医学部, リサーチアシスタント (20464125)
OGAWA Akashi 浜松医科大学, 医学部, 医員 (90467225)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | レニン・アンジオテンシン系 / 高塩分 / プロレニン / 腎線維化 / アンジオテンシン / レニン / (プロ)レニン受容体 / 塩分摂取 / 慢性腎臓病 / プロレニン受容体 / 閉塞性腎障害 |
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| Research Abstract |
Although activation of intrarenal renin angiotensin system (RAS) is involved in the progression of kidney fibrosis, it is unknown how salt load that suppresses circulating RAS aggravates kidney fibrosis. This study demonstrated that high salt intake increased the apical membranous transition of (pro)renin receptor in collecting ducts and connecting tubules, resulting in the increased binding of prorenin and renin proteins without concomitant renin mRNA expression, followed by non-proteolytic activation of prorenin and angiotensin II generation, with resultant worsening of renal fibrosis in chronic anti-thymocyte serum nephritis on high salt intake.
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