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Role of carbonyl stress on renal circulation and development of hypertension

Research Project

Project/Area Number 20590970
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTohoku University

Principal Investigator

MORI Takefumi  Tohoku University, 病院, 准教授 (40375001)

Co-Investigator(Renkei-kenkyūsha) ITO Sadayoshi  東北大学, 大学院・医学系研究科, 教授 (40271613)
NAKAYAMA Masaaki  福島県立医科大学, 医学部, 教授 (60217940)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords酸化ストレス / 糖終末代謝産物 / 慢性腎臓病 / 高血圧 / メチルグリオキサール / カルボニルストレス / ミトコンドリア / 尿細管 / 腎血流 / カルボニル物質 / 腎循環
Research Abstract

Carbonyl compound methylglyoxal induced salt sensitive hypertension, insulin resistance and renal injury which involves in the pathogenesis of chronic kidney disease. These mechanisms are associated with enhanced renal NAD(P)H oxidase, tubular oxygen metabolism and mitochondrial electron chain transport which could result in enhanced medullary carbonyl/oxidative stress and ischemia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009 2008 Other

All Journal Article (28 results) (of which Peer Reviewed: 17 results) Presentation (29 results) Remarks (1 results)

  • [Journal Article] Skin advanced glycation end product accumulation and muscle strength among adult men.2011

    • Author(s)
      Haruki Momma, Kaijun Niu, Yoritoshi Kobayashi, Lei Guen, Mika Sato, Hui Guo, Masahiko Chujo, Atsushi Otomo, Cui Yufei, Hiroko Tadaura, Tatsunori Saito, Takefumi Mori, Toshio Miyata, RyoichiNagatomi.
    • Journal Title

      European Journal of Applied Physiology in Press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] AKI発症と酸化/カルボニルストレス2011

    • Author(s)
      森建文、宮田敏男、佐藤博、伊藤貞嘉
    • Journal Title

      Modern Physician Vol.31No.1

      Pages: 30-33

    • Related Report
      2010 Final Research Report
  • [Journal Article] Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.2010

    • Author(s)
      Susumu Ogawa, Keisuke Nakayama, Masaaki Nakayama, Takefumi Mori, Masato Matsushima, Masashi Okamura, Miho Senda, Kazuhiro Nako, Toshio Miyata, Sadayoshi Ito.
    • Journal Title

      Hypertension. 56(3)

      Pages: 471-476

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Advanced Glycation End Products in Aging-Related Disease.2010

    • Author(s)
      Ryoji Nagai, Takefumi Mori, Yasuhiko Yamamoto, Yuichi Kaji, Yoshikazu Yonei
    • Journal Title

      Anti-Aging Medicine. 7(10)

      Pages: 112-119

    • NAID

      130000428490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アンジオテンシンIIによる腎髄質機能調節2010

    • Author(s)
      森建文
    • Journal Title

      日腎会誌

      Volume: 52(2) Pages: 114-119

    • NAID

      10026289800

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 基礎的病態を理解する:腎血流調節2010

    • Author(s)
      森建文
    • Journal Title

      循環器臨床サピア

      Volume: 7 Pages: 80-89

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アルブミン尿の出現機序と心血管病との関連2010

    • Author(s)
      森建文
    • Journal Title

      Medical Science Digest

      Volume: Vol36(6) Pages: 12-15

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 糸球体における循環器調節2010

    • Author(s)
      細谷拓真
    • Journal Title

      Pharma Medica

      Volume: Vol28(2) Pages: 49-53

    • Related Report
      2010 Annual Research Report
  • [Journal Article] CKD合併高血圧患者における血圧日内変動とオルメサルタンの特徴2010

    • Author(s)
      堀内正嗣
    • Journal Title

      Medical Tribune

      Volume: 11(4) Pages: 14-15

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アンジオテンシンIIと微小循環障害2010

    • Author(s)
      千田美穂
    • Journal Title

      最新医学

      Volume: 第65巻 Pages: 42-51

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 利尿薬2010

    • Author(s)
      中澤かほり
    • Journal Title

      レジデント

      Volume: Vol3(3) Pages: 43-49

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Significance of Advanced Glycation End Products in Aging-Related Disease.2010

    • Author(s)
      Ryoji Nagai
    • Journal Title

      Anti-Aging Medicine.

      Volume: 7(10) Pages: 112-119

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure.2010

    • Author(s)
      Takuo Hirose
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 299(1) Pages: 128-34

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of aneiotensin II blockade.2010

    • Author(s)
      Genei Ihara
    • Journal Title

      J Hypertens.

      Volume: 11 Pages: 2289-98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.2010

    • Author(s)
      Susumu Ogawa
    • Journal Title

      Hypertension

      Volume: 56(3) Pages: 471-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis.2010

    • Author(s)
      Takefumi Mori
    • Journal Title

      Clin Exp Pharmacol Physiol.

      Volume: 37(9) Pages: 877-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy.2009

    • Author(s)
      Susumu Ogawa , Hiroyuki Kobori, Naro Ohashi, Maki Urushihar, Akira Nishiyama, Takefumi Mori, Tsuneo Ishizuka, Kazuhiro Nako, Sadayoshi Ito.
    • Journal Title

      Biomark Insights. 4

      Pages: 97-102

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylglyoxal Contributes to the Development of Insulin Resistance and Salt Sensitivity in Sprague Dawley Rats.2009

    • Author(s)
      Qi Guo, Takefumi Mori, Jiang Yue, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Ying Sun, Takuma Hosoya, Akihiro Kawamata, Susumu Ogawa, Masaaki Nakayama, Toshio Miyata, Sadayoshi Ito.
    • Journal Title

      J.Hypertens. 27(8)

      Pages: 1664-1671

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of renal perfusion pressure on renal medullary H2O2 and NO production.2009

    • Author(s)
      Chunhua Jin, Chunyan Hu, Aaron Polichnowski, Takefumi Mori, Meredith Skelton, Sadayoshi Ito, Allen W.Cowley, Jr.
    • Journal Title

      Hypertension. 53(6)

      Pages: 1048-1053

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease.2009

    • Author(s)
      Takefumi Mori, Sadayoshi Ito.
    • Journal Title

      IMARS highlights. 4(1)

      Pages: 15-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease2009

    • Author(s)
      森建文
    • Journal Title

      IMARS highlights. 4(1)

      Pages: 15-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease2009

    • Author(s)
      Takefumi Mori, 他
    • Journal Title

      IMARS highlights 4

      Pages: 15-15

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Methylglyoxal Contributes to the Development of Insulin Resistance and Salt Sensitivity in Sprague Dawley Rats2009

    • Author(s)
      Qi Guo, 他
    • Journal Title

      J. Hypertens (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague Dawley rats2009

    • Author(s)
      SatoshiEndo, 他
    • Journal Title

      Hypertens Res (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of renal perfusion pressure on renal.medullary H202 and NO production2009

    • Author(s)
      Chunhua Jin, 他
    • Journal Title

      Hypertension (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性腎臓病の進展に対するMethylglyoxalの影響2008

    • Author(s)
      森建文、陳献廣、胡春艶、大崎雄介、朱万君、米城淑美、郭〓、中道崇、細谷拓真、長澤将、井上英行、小川晋、中山昌明、伊藤貞嘉
    • Journal Title

      Therapeutic Research 29(11)

      Pages: 1884-1886

    • Related Report
      2010 Final Research Report
  • [Journal Article] High Perfusion Pressure Accelerates Renal Injury in Salt-Sensitive Hypertension2008

    • Author(s)
      Takefumi Mori, 他
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 1472-1482

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性腎臓病の進展に対するMethylglyoxalの影響2008

    • Author(s)
      森建文, 他
    • Journal Title

      Therapeutic Research 28

      Pages: 1884-1886

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] アンジオテンシンIIによる腎尿細管ミトコンドリア酸化ストレスの役割2011

    • Author(s)
      森建文, 他
    • Organizer
      第84回日本内分泌学会学術総会(口演)
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Angiotensin II Increases Mitochondrial Reactive Oxygen Species through Mitochondrial Respiratory Chain in Medullary Thick Ascending Limb of the Rat Kidney2010

    • Author(s)
      Yi Lu, Takefumi Mori, Chunyan Hu, Yusuke Ohsaki,Bryan C Dickinson, Christopher J Chang, Allen W Cowley Jr, Sadayoshi Ito.
    • Organizer
      64^<th> Council for High Blood Pressure Research
    • Place of Presentation
      Washington DC ,USA(Poster)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性腎臓病の心腎血管障害に対するカルボニルストレスの役割2010

    • Author(s)
      森建文
    • Organizer
      第40回日本腎臓学会東部学術大会
    • Place of Presentation
      台湾
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] リアルタイムイメージングによる腎尿細管上皮細胞のブドウ糖誘導性ミトコンドリア酸化ストレスの検討(若手希望)2010

    • Author(s)
      芦毅、森建文、宮田敏男、伊藤貞嘉
    • Organizer
      第20回メイラード学会(口演)
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Drug discovery and development from the academia targeting carbonyl stress in renal disease Sunday2010

    • Author(s)
      Takefumi Mori
    • Organizer
      International Forum on Advances in Diabetes Complications
    • Place of Presentation
      台湾
    • Year and Date
      2010-07-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhanced oxidative and carbonyl stress predicts salt sensitive in obese young adults.2010

    • Author(s)
      Takefumi Mori
    • Organizer
      Experimental Biology2010
    • Place of Presentation
      米国
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhanced oxidative and carbonyl stress predicts salt sensitive in obese young adults.2010

    • Author(s)
      Takefumi Mori, Akihiro Kawamata, Takuma Hosoya, Yoshimi Yoneki, Eiko Mitsui, Yoko Hasegawa, Michi Ota, Megumi Ito, Hiromi Sato, Shigeru Kabayama, Sadayoshi Ito, Wataru Hida
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      California, USA (Oral and Poster)
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Carbonyl and oxidative stress may predict salt sensitivity of hypertension in obese young adults2010

    • Author(s)
      Takefumi Mori, Akihiro Kawamata, Takuma Hosoya, Yoshimi Yoneki, Eiko Mitsui, Yoko Hasegawa, Michi Ohta, Shigeru Kabayama, Kyozo Suyama, Toshinobu Sato, Takuo Hirose, Masaaki Nakayama, Toshio Miyata, Yutaka Imai, Sadayoshi Ito, Wataru Hida.
    • Organizer
      ISN nexus
    • Place of Presentation
      Kyoto, Japan (Poster)
    • Year and Date
      2010-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Carbonyl stress mediated myocardial fi brosis and renal injury in Dahl salt sensitive rats2010

    • Author(s)
      Takefumi Mori, Qi Guo, Chunyan Hu, Xianguang Chen, Yusuke Ohsaki, Yoshimi Yoneki, Toshio Miyata, Masayuki Kanazawa, Masahiro Kohzuki, Sadayoshi Ito.
    • Organizer
      ISN nexus
    • Place of Presentation
      Kyoto, Japan (Poster)
    • Year and Date
      2010-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Carbonyl stress mediated myocardial fi brosis and renal injury in Dahl salt sensitive rats2010

    • Author(s)
      Takefumi Mori
    • Organizer
      ISN nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Carbonyl and oxidative stress may predict salt sensitivity of hypertension in obese young adults2010

    • Author(s)
      Takefumi Mori
    • Organizer
      ISN nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Carbonyl stress mediated cardio-renal connection in Dahl salt sensitive rats.2010

    • Author(s)
      Qi Guo, Takefumi Mori, Xianguang Chen, Chunyan Hu Yusuke Ohsaki, Yoshimi Yoneki, Toshio Miyata, Sadayoshi Ito.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto (Poster)
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] メチルグリオキサール(MG)の糖尿病合併症進展予測因子としての検討2009

    • Author(s)
      森建文
    • Organizer
      第7回腎と高血圧
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食品中のカルボニルに起因する腎障害2009

    • Author(s)
      森建文
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性腎臓病の腎、心血管障害に対するカルボニルストレスの役割2009

    • Author(s)
      森建文
    • Organizer
      第13回日本心血管内分泌代謝学会学術総会(口演)
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性腎臓病の腎、心血管障害に対するカルボニルストレスの役割2009

    • Author(s)
      森建文
    • Organizer
      第13回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Carbonyl Stress on Pathogenesis of Chronic Kidney Disease.2009

    • Author(s)
      T Mori, Q Guo, M Nakayama, S Ogawa, K Suyama, T Miyata, S Ito.
    • Organizer
      10^<th> International Symposium on the Maillard Reaction.
    • Place of Presentation
      Cairns, Australia (Oral invited speker)
    • Year and Date
      2009-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性腎臓病の進展因子に対するMethylglyoxalの役割2009

    • Author(s)
      郭其, 森建文, 大崎雄介, 米城淑美, 江悦, 胡春艶, 中道崇, 細谷拓真, 小川晋, 中山昌明, 佐藤博, 宮田敏男, 伊藤貞嘉
    • Organizer
      第52回日本腎臓学会学術総会(口演)
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Losartan reverse thiazide diuretics-exacerbated insulin resistance through modulation capillary density in skeletal muscle in fructose-fed rats.2009

    • Author(s)
      Qi Guo, Takefumi Mori, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Takashi Nakamichi, Takuma Hosoya, Hiroshi Sato, Sadayoshi Ito.
    • Organizer
      10th International Symposium on Mechanisms of Vasodilatation.
    • Place of Presentation
      Matsushima, Miyagi, Japan (Peer reviewed, Poster)
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Methylglyoxalのメラミン腎障害に及ぼす影響2009

    • Author(s)
      森建文, 郭其, 孫頴, 大崎雄介, 胡春艶, 佐藤博, 須山享三, 宮田敏男, 伊藤貞嘉
    • Organizer
      第52回日本腎臓学会学術総会(口演)
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Carbonyl Stress on Pathogenesis of Chronic Kidney Disease2009

    • Author(s)
      森建文
    • Organizer
      10th International Symposium on the Maillard Reaction
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carbnyl Stress Mediated Myocardial Fibrosis and Renal Injury in Dahl Salt Sensitive Rats.2009

    • Author(s)
      森建文
    • Organizer
      Satellite Symposium of the 36th Congress of the International Union of physiological Sciences
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] メチルグリオキサールの食塩感受性高血圧を介した慢性腎臓病進展機序2008

    • Author(s)
      森建文, 郭〓, 江悦, 胡春艶, 大崎雄介, 中道崇, 細谷拓真, 長澤将, 井上英行, 小川晋, 中山昌明、宮田敏男、伊藤貞嘉
    • Organizer
      第20回日本糖尿病性腎症研究会(口演)
    • Place of Presentation
      東京
    • Year and Date
      2008-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] メチルグリオキサールの食塩感受性高血圧を介した慢性腎臓病進展機序2008

    • Author(s)
      森建文, 他
    • Organizer
      第20回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病および慢性腎臓病におけるMethylglyoxalの役割2008

    • Author(s)
      郭〓, 他
    • Organizer
      第6回腎と高血圧Update
    • Place of Presentation
      東京
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] メチルグリオキサールのインスリン抵抗性に対する作用と食塩感受性との関連2008

    • Author(s)
      郭〓、森建文、江悦、大崎雄介、米城淑美、胡春艶、中道崇、細谷拓真、長澤将、井上英行、小川晋、中山昌明、宮田敏男、伊藤貞嘉
    • Organizer
      第31回日本高血圧学会総会(ポスター)
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-11
    • Related Report
      2010 Final Research Report
  • [Presentation] メチルグリオキサールのインスリン抵抗性に対する作用と食塩感受性との関連2008

    • Author(s)
      郭〓, 他
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高血圧による腎内酸化ストレスの上昇メカニズム2008

    • Author(s)
      胡春艶, 他
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of renal decapsulation upon arterial pressure induced medullary oxidative stress2008

    • Author(s)
      Chunhua Jin, 他
    • Organizer
      American Heart Association High Blood Pressure Council
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.int2.med.tohoku.ac.jp

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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