| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Ultrafiltration failure (UFF) and peritoneal dysfunction are impotrtant complications of long-term peritoneal dialysis (PD). We investigated angiogenesis, Iymphangiogenesis and peritoneal fibrosis in UFF. We demonstrated that CTGF acts downstream of TGF-β and plays an important role in peritoneal fibrosis, and that CTGF concentrations in PD effluent might be a biomarker of peritoneal function. We showed that increase of VEGF-C production and lymphangiogenesis in peritoneum are associated with UFF. VEGF-C is produced mainly by peritoneal mesothelial cells through TGF-β-VEGF-C pathway. Suppression on the TGF-β-CTGF and -VEGF-C pathway might be effective to regulate the peritoneal fibrosis and increase of peritoneal permeability.
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