• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of Angiotensin Receptor Binding Protein in The Cardiovascular Regulation

Research Project

Project/Area Number 20590979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionYokohama City University

Principal Investigator

TAMURA Kouichi  Yokohama City University, 医学部, 准教授 (40285143)

Co-Investigator(Kenkyū-buntansha) UMEMURA Satoshi  横浜市立大学, 医学研究科, 教授 (00128589)
Co-Investigator(Renkei-kenkyūsha) ORIUCHI Masatsugu  愛媛大学, 医学研究科, 教授 (40150338)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords高血圧学 / 分子心臓血管病態学 / シグナル伝達 / 循環器・高血圧 / 生体分子 / 生理活性 / トランスレーショナルリサーチ
Research Abstract

We hypothesized that a downregulation of the cardiac ATRAP to angiotensin II type 1 receptor ratio is involved in the pathogenesis of cardiac hypertrophy. To examine this hypothesis, we next generated transgenic mice expressing ATRAP specifically in cardiomyocytes under control of the α-myosin heavy chain promoter. In cardiac-specific ATRAP transgenic mice, the development of cardiac hypertrophy, activation of p38 mitogen-activated protein kinase, and expression of hypertrophy-related genes in the context of angiotensin II treatment were completely suppressed, in spite of there being no significant difference in blood pressure on radiotelemetry between the transgenic mice and littermate control mice. These results demonstrate that cardiomyocyte-specific overexpression of ATRAP in vivo abolishes the cardiac hypertrophy provoked by chronic angiotensin II infusion, thereby suggesting ATRAP to be a novel therapeutic target in cardiac hypertrophy.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (45 results)

All 2010 2009 2008 Other

All Journal Article (31 results) (of which Peer Reviewed: 30 results) Presentation (8 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K(他14名,2番目)(corresponding author and equal contributor), Minamisawa S, Umemura S, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of angiotensin II type 1 receptor interacting molecule in normal human kidney and IgA nephropathy.2010

    • Author(s)
      Masuda S, Tamura K(他18名,2番目)(corresponding author and equal contributor), Umemura S, et al.
    • Journal Title

      Am J Physiol Renal Physiol. 299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sustained inhibition of oxidized low-density lipoprotein is involved in the long-term therapeutic effects of apheresis in dialysis patients.2010

    • Author(s)
      Tsurumi-Ikeya Y, Tamura K(他12名,2番目)(corresponding author and equal contributor), Umemura S, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 1058-1065

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K(他18名,2番目)(corresponding author), Horiuchi M, Minamisawa S, Umemura S, et al.
    • Journal Title

      Hypertension 55

      Pages: 1157-1164

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K, et al.
    • Journal Title

      Hypertension

      Volume: 55 Pages: 1154-1164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy.2010

    • Author(s)
      Masuda S, Tamura K, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 299 Pages: 720-731

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 299 Pages: 991-1003

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II receptor blockers on the relationships between ambulatory blood pressure and anti-hypertensive effects, autonomic function, and health-related quality of life.2009

    • Author(s)
      Okano Y, Tamura K(他5名,2番目), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 680-689

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure variability as well as blood pressure level is important for left ventricular hypertrophy and brachial-ankle pulse wave velocity in hypertensives.2009

    • Author(s)
      Ozawa M, Tamura K(他13名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 669-679

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway.2009

    • Author(s)
      Min LJ, Mogi M, Tamura K(他9名,3番目), Horiuchi M.
    • Journal Title

      J Mol Cell Cardiol. 47

      Pages: 798-809

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II type 1 receptor blocker on ambulatory blood pressure variability in hypertensive patients with overt diabetic nephropathy.2009

    • Author(s)
      Masuda S, Tamura K(他9名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Hypertens Res. 32

      Pages: 950-955

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L.2009

    • Author(s)
      Araki N, Tamura K(他11名,9番目), Umemura S, et al.
    • Journal Title

      Biochem Biophys Res Commun. 388

      Pages: 290-296

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.2009

    • Author(s)
      Mitsuhashi H, Tamura K(他18名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Atherosclerosis 207

      Pages: 186-190

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an increased short-term blood pressure variability on ambulatory blood pressure monitoring as a coronary risk factor in diabetic hypertensives.2009

    • Author(s)
      Ozawa M, Tamura K(他15名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 259-270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II receptor blockers on relationships between 24-hour blood pressure, autonomic function, and health-related QOL.2009

    • Author(s)
      Okano Y, Tamura K(他5名,2番目), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 250-258

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis.2009

    • Author(s)
      Shigenaga A, Tamura K(他16名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Nephron Clin Pract. 112

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy.2009

    • Author(s)
      Yoshida S, Tamura K(他12名,8番目), Umemura S, et al.
    • Journal Title

      Nephron Exp Nephrol. 111

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure.2009

    • Author(s)
      Ushio H, Tamura K(他8名,5番目), Umemura S, et al.
    • Journal Title

      Clin Exp Nephrol. 13

      Pages: 480-485

    • NAID

      10027226625

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway2009

    • Author(s)
      Min LJ, Mogi M, Tamura K, et al.
    • Journal Title

      J Mol Cell Cardiol. 47

      Pages: 798-809

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II type 1 receptor blocker on ambulatory blood pressure variability in hypertensive patients with overt diabetic nephropathy2009

    • Author(s)
      Masuda S, Tamura K, et al.
    • Journal Title

      Hypertens Res. 32

      Pages: 950-955

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of losartan on ambulatory short-term blood pressure variability and cardio vascular remodeling in hypertensive patients on hemodialysis2009

    • Author(s)
      Mitsuhashi H, Tamura K, et al.
    • Journal Title

      Atherosclerosis 207

      Pages: 186-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      田村功一
    • Journal Title

      高血圧診療ハンドブック(羊土社)

      Pages: 22-23

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of LDL Apheresis on atherosclerosis is beyond its cholesterol lowering in hemodialysis patients : A Pilot Study.2008

    • Author(s)
      Tsurumi-Ikeya Y, Tamura K(他10名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Jpn J Aheresis. 27

      Pages: 231-235

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule.2008

    • Author(s)
      Shigenaga A, Tamura K(他12名,2番目)(corresponding author), Horiuchi M, Umemura S, et al.
    • Journal Title

      Hypertension 52

      Pages: 672-678

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ambulatory blood pressure variability is increased in diabetic hypertensives.2008

    • Author(s)
      Ozawa M, Tamura K(他13名,2番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 30

      Pages: 213-224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behcet's disease complicated by IgA nephropathy with nephrotic syndrome.2008

    • Author(s)
      Hashimoto T, Tamura K(他13名,13番目), Umemura S, et al.
    • Journal Title

      Clin Exp Nephrol. 12

      Pages: 224-227

    • NAID

      10024141297

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant : implications for essential hypertension.2008

    • Author(s)
      Araki N, Tamura K(他10名,6番目), Umemura S, et al.
    • Journal Title

      Hypertension 51

      Pages: 773-777

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ambulatory blood pressure and heart rate in hypertensives with renal failure : comparison between diabetic nephropathy and non-diabetic glomerulopathy.2008

    • Author(s)
      Tamura K(他13名,1番目)(corresponding author), Umemura S, et al.
    • Journal Title

      Clin Exp Hypertens. 30

      Pages: 33-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule.2008

    • Author(s)
      Shigenaga A, Tamura K, et al.
    • Journal Title

      Hypertension 52

      Pages: 672-678

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ambulatory blood pressure and heart rate in hypertensives with renal failure : comparison between diabetic nephropathy and non-diabetic glomerulopathy.2008

    • Author(s)
      Tamura K, et al.
    • Journal Title

      Clinical and Experimental Hypertension 30

      Pages: 33-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant : implications for essential hypertension.2008

    • Author(s)
      Araki N, Umemura M, Tamura K, Ishigami T, et al.
    • Journal Title

      Hypertension 51

      Pages: 773-777

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Angiotensin II Type 1 Receptor-Associated Protein Mediates a Novel Inhibitory Effect on Cardiac Hypertrophy In Vivo2010

    • Author(s)
      Tamura K, et al.
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      McCormick Place-Chicago, IL, USA(招待講演)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Angiotensin II Type 1 Receptor-Associated Protein Mediates a Novel Inhibitory Effect on Cardiac Hypertrophy In Vivo.2010

    • Author(s)
      田村功一, et al.
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, IL
    • Related Report
      2010 Final Research Report
  • [Presentation] アンジオテンシンAT1受容体特異的結合因子ATRAPの機能的意義についての検討2009

    • Author(s)
      田村功一
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] AT1受容体阻害薬は高血圧合併腹膜透析患者の血圧短期変動性を改善する.シンポジウム4:透析患者の心血管事故に及ぼす神経・内分泌因子の影響2009

    • Author(s)
      田村功一, 他
    • Organizer
      第54回日本透析医学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 血液透析患者における閉塞性動脈硬化症に対するLDLアフェレシスの長期的作用機序における酸化ストレスの意義についての検討.ワークショップ7:透析患者に酸化的ストレスをどう抑えるか~薬剤から運動まで~2009

    • Author(s)
      田村功一, 他
    • Organizer
      第54回日本透析医学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] AT1受容体阻害薬は高血圧合併腹膜透析患者の血圧短期変動性を改善する2009

    • Author(s)
      田村功一, 他
    • Organizer
      第54回日本透析医学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Angiotensin II Type 1 Receptor Blocker on Ambulatory Blood Pressure Profile in Hypertensive Patients with Overt Diabetic Nephropathy.2009

    • Author(s)
      田村功一, et al.
    • Organizer
      The 63nd High Blood Pressure Research Conference in association with the Council on the Kidney in Cardiovascular Disease
    • Place of Presentation
      Chicago, IL
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of Angiotensin II Receptor Blocker on Tissue Expression Balance between Angiotensin II receptor and Its inhibitory Binding Molecule ATRAP.2008

    • Author(s)
      Tamura K, et al.
    • Organizer
      The 62nd High Blood Pressure Research Conference in association with the Council on the Kidney in Cardiovascular Disease.
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Book] 最新高血圧診療学2010

    • Author(s)
      東公一, 田村功一
    • Publisher
      永井書店
    • Related Report
      2010 Final Research Report
  • [Book] 最新高血圧診療学2010

    • Author(s)
      東公一、田村功一
    • Publisher
      永井書店
    • Related Report
      2010 Annual Research Report
  • [Book] 高血圧ナビゲーター.2008

    • Author(s)
      田村功一, 重永豊一郎, 梅村敏.
    • Total Pages
      327
    • Publisher
      メデイカルレビュー社(東京)
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.yokohama-cu.ac.jp/amedrc/res/tamura_1005.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.yokohama-cu.ac.jp/amedre/res/tamura_1005.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.yokohama-cu.ac.jp/amedrc/100510_tamura.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi