| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Extracellular calcium concentration regulates parathyroid hormone (PTH) secretion via calcium-sensing receptor (CaR) on the parathyroid cell surface. N-terminal truncation of PTH is also regulated by extracellular calcium concentration. The N-terminal truncation is thought to be one of the regulatory mechanisms to secrete 1-84PTH from parathyroid cells, however, signal pathways of the mechanism in the cells are not yet reported. We attempt to determine whether the pathways of N-terminal truncation are identical from those of (1-84)PTH secretion in primary cultured human parathyroid cells. It is suggested that the N-terminal truncation of PTH regulated by extracellular calcium concentration has at least partly independent intracellular signaling systems from the (1-84)PTH secretion in human parathyroid cells.
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