Mechanism elucidation of calcification with phosphate-induced and endothelial injury in rat aortic tissue culture
| Project/Area Number |
20590981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HATAMURA Ikuji Wakayama Medical University, 保健医療学部, 教授 (80336883)
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| Co-Investigator(Kenkyū-buntansha) |
SHIIZAKI Kazuhiro 自治医科大学, 医学部, 助教 (10423930)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血管石灰化 / 高リン / 血管内膜障害 / 血管培養 / 高リン負荷 / 内膜障害 / メンケベル型血管石灰化 / PTA |
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| Research Abstract |
The cardiovascular calcification is one of the factors to cause the cardiovascular complication that is the first place of the cause of death of the hemodialysis patients. Therefore to control the vascular calcification prevents the complication of the patient and becomes lower the death rate of the patients. In this study, it was confirmed that vascular calcification was more strongly induced in the high serum phosphorus that most of hemodialysis patients contracted a disease with endothelial injury. It was suggested that it was necessary for the calcification prevention after endarterectomy to improve hyperphosphatemia in patients.
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Report
(4 results)
Research Products
(19 results)
