Regression of hypertension : molecular analysis and epigenetic assessment
Project/Area Number |
20590984
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Keio University |
Principal Investigator |
SASAMURA Hiroyuki Keio University, 医学部, 准教授 (00235293)
|
Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 高血圧 / 退行 / レニンーアンジオテンシン系 / 糸球体硬化 |
Research Abstract |
Hypertension is the most prevalent disease in Japan, and affects at least one in four of the general population. Although hypertension is considered to be a progressive, irreversible disease, we demonstrated in this study that reversal or regression of hypertension may be feasible in animal models of hypertension. Regression of hypertension was achieved by 'pulse' treatment with an angiotensin receptor blocker at 10-50 times the normal dose, by a mechanism involving reversal of renal arteriolar hypertrophy.
|
Report
(4 results)
Research Products
(38 results)