Analyses of amyloid protein in lens in correlation with cognitive function
| Project/Area Number |
20590987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAMAOKA Akira University of Tsukuba, 大学院・人間総合科学研究科, 教授 (50192183)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIDOKORO Yasushi 筑波大学, 大学院・人間総合科学研究科, 講師 (80447250)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルツハイマー病 / アミロイドβ蛋白 / 水晶体 / 白内障 / 認知症 / αBクリスタリン / αBクリスタリ |
|---|
| Research Abstract |
In this investigation, we performed to extract amyloid β protein (Aβ) in lens tissues obtained from cataract patients without dementia, and to measure Aβ by enzyme-linked immunosorbent assays (ELISAs), revealing that Aβx-42 was deposited in lens in a small amount and increased in parallel with severity of cataract.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan2010
Author(s)
Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H
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Journal Title
Intern Med 49(Epub)
Pages: 331-4
NAID
Related Report
Peer Reviewed
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