Analyses of amyloid protein in lens in correlation with cognitive function

• Project/Area Number: 20590987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: University of Tsukuba
• Principal Investigator: TAMAOKA Akira University of Tsukuba, 大学院・人間総合科学研究科, 教授 (50192183)
• Co-Investigator(Kenkyū-buntansha): TOMIDOKORO Yasushi 筑波大学, 大学院・人間総合科学研究科, 講師 (80447250)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アルツハイマー病 / アミロイドβ蛋白 / 水晶体 / 白内障 / 認知症 / αBクリスタリン / αBクリスタリ

Research Abstract

In this investigation, we performed to extract amyloid β protein (Aβ) in lens tissues obtained from cataract patients without dementia, and to measure Aβ by enzyme-linked immunosorbent assays (ELISAs), revealing that Aβx-42 was deposited in lens in a small amount and increased in parallel with severity of cataract.

Research Products

• [Journal Article] TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan (2010)
  • Author(s): Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H
  • Journal Title: Intern Med 49(Epub) Pages: 331-4
  • NAID: 130000152618
  • Peer Reviewed
• [Journal Article] Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells (2010)
  • Author(s): Oda A, Tamaoka A, Araki W
  • Journal Title: J Neurosci Res 85 Pages: 1137-114
  • Peer Reviewed
• [Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system (2010)
  • Author(s): Tomidokoro Y, Tamaoka A, Holton JL, Lashley T, Frangione B, Revesz T, Rostagno A, Ghiso J
  • Journal Title: Hirosaki Igaku 61(Suppl)
  • Peer Reviewed
• [Journal Article] CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. (2010)
  • Author(s): Matsumoto L
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system. (2010)
  • Author(s): Tomidokoro Y
  • Journal Title: Hirosaki Igaku Volume: 61(Suppl)
  • Peer Reviewed
• [Journal Article] Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease. (2010)
  • Author(s): Tokuda T
  • Journal Title: Neurology Volume: 75 Pages: 1766-1772
  • Peer Reviewed
• [Journal Article] MEK inhibitors suppress beta-amyloid production by altering the level of abeta-C-terminal fragment of amyloid precursor protein in neuronal cells. (2010)
  • Author(s): Araki W
  • Journal Title: FEBS Lett Volume: 584 Pages: 3410-1
  • Peer Reviewed
• [Journal Article] Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy. (2010)
  • Author(s): Hirohata M
  • Journal Title: Eur J Neurol 17 Pages: 823-829
  • Peer Reviewed
• [Journal Article] TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan. (2010)
  • Author(s): Tamaoka A
  • Journal Title: Intern Med 49 Pages: 331-334
  • NAID: 130000152618
  • Peer Reviewed
• [Journal Article] Discordant clinicopathologic phenotypes in a Japanese kindred of fatal familial insomnia. (2010)
  • Author(s): Saitoh Y
  • Journal Title: Neurology 74 Pages: 86-89
  • Peer Reviewed
• [Journal Article] Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. (2010)
  • Author(s): Oda A
  • Journal Title: J neurosci Res 88 Pages: 1137-1145
  • Peer Reviewed
• [Journal Article] Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions. (2009)
  • Author(s): Yokota O
  • Journal Title: Acta Neuropathol 117 Pages: 429-444
  • Peer Reviewed
• [Journal Article] IGF-1 promotes beta-amyloid production by a secretase-independent mechanism (2009)
  • Author(s): Araki W
  • Journal Title: Biochem Biophys Res Commun 380 Pages: 111-114
  • Peer Reviewed
• [Journal Article] Urine analysis of patients exposed to phenylarsenic compounds viaaccidental pollution. (2008)
  • Author(s): Kinoshita K
  • Journal Title: J Chromatogr B Analyt Technol Biomed Life Sci 867 Pages: 179-188
  • Peer Reviewed
• [Presentation] 白内障水晶体におけるアミロイドβペプチドの定量化の可能性-非認知症患者検体での検討 (2010)
  • Author(s): 赤松恵,冨所康志,加治優一,大鹿哲郎,玉岡晃
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] 認知症の診断と治療の実際 (2010)
  • Author(s): 玉岡晃
  • Organizer: 平成22年度日本内科学会生涯教育講演会
  • Place of Presentation: 石川県立音楽堂(金沢)
  • Year and Date: 2010-09-12
• [Presentation] 認知症の診断と治療の実際 (2010)
  • Author(s): 玉岡晃
  • Organizer: 平成22年度日本内科学会生涯教育講演会
  • Place of Presentation: 横浜国際会議場(横浜)
  • Year and Date: 2010-05-30
• [Presentation] Familial British Dementiaアミロイド分子N末端のピロ化は中枢神経系に限定されない. (2010)
  • Author(s): 冨所康志
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-05-22
• [Presentation] 認知症を伴わない白内障患者の水晶体におけるアミロイドβペプチドの解析 (2010)
  • Author(s): 赤松恵,冨所康志,加治優一,大鹿哲郎,玉岡晃
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] 認知症を伴わない白内障患者の水晶体におけるアミロイドβペプチドの解析 (2010)
  • Author(s): 赤松恵
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-05-21
• [Presentation] 認知症の診断と治療の実際. (2010)
  • Author(s): 玉岡晃
  • Organizer: 日本内科学会生涯教育講演会
  • Place of Presentation: 大阪
  • Year and Date: 2010-02-07
• [Presentation] Pyroglutamate formation at the N-terminal of ABri molecules in familial British dementia is not restricyed to the central nervous system. (2009)
  • Author(s): Yasushi Tomidokoro
  • Organizer: The 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-28
• [Presentation] PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM. (2009)
  • Author(s): Yasushi Tomidokoro
  • Organizer: 39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago(USA)
• [Presentation] TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan (2009)
  • Author(s): 玉岡晃
  • Organizer: 39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago(USA)
• [Book] パーフェクトブック2010(横田千津子,池田宇一,大越教夫監修・編集)(アルツハイマー病・認知症・病気と薬) (2010)
  • Author(s): 玉岡晃
  • Publisher: 南山堂(東京)
• [Book] 病気と薬 パーフェクトブック2010 (2010)
  • Author(s): 玉岡晃
  • Total Pages: 6
  • Publisher: 南山堂
• [Book] 新体系看護学全書19 成人看護学6 脳・神経 (2010)
  • Author(s): 玉岡晃
  • Total Pages: 13
  • Publisher: メヂカルフレンド社
• [Book] Adolescent Schizophrenia(ed by James T. Nillinghouse, Robert P.Trotman)(Body image deviation in chronic schizophrenia : new research.) (2009)
  • Author(s): Reiko Koide, Akira Tamaoka
  • Publisher: Nova Biomedical Books
• [Book] Body image deviation in chronic schizophrenia : new research in Adolescent schizophrenia. (2009)
  • Author(s): Koide R
  • Total Pages: 59
  • Publisher: Nova Biomedical Books
• [Book] アルツハイマー病・認知症.病気と薬 パーフェクトブック2009. (2009)
  • Author(s): 玉岡晃
  • Total Pages: 6
  • Publisher: 南山堂
• [Book] 慢性炎症性脱髄性多発根ニューロパチー.神経疾患最新の治療. (2009)
  • Author(s): 石井亜紀子
  • Total Pages: 4
  • Publisher: 南江堂
• [Book] PERSISTENT ORGANIC POLLUTANTS (POPS) RESEARCH IN ASIA (2008)
  • Author(s): Ishii K
  • Total Pages: 13
  • Publisher: ISEBU
• [Remarks] ホームページ等
  • URL: http://www.md.tsukuba.ac.jp/chs/clinical_sciences/tamaoka.htm