| Project/Area Number |
20590988
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
KUWABARA Satoshi Chiba University, 大学院・医学研究院, 教授 (70282481)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masahiro 千葉大学, 大学院・医学研究院, 講師 (70345023)
KANAI Kazuaki 千葉大学, 医学部附属病院, 助教 (10375751)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | クロウ・深瀬症候群 / 自己末梢血幹細胞移植 / サリドマイド / 神経免疫学 / 神経病態免疫学 |
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| Research Abstract |
POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome is potentially fatal disease, and patients' quality of life deteriorates because of progressive neuropathy. The aim of this study was to clarify the effects of (1) high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) and thalidomide therapy. PBSCT was performed in 21 patients under age 66 years, and resulted in obvious improvement in neuropathy as well as other symptoms. Fifteen patients aged 66 years or older received thalidomide, resulting in moderate clinical improvement (n=12) and stabilization of symptoms (n=3). Based on the findings, we proposed a treatment guideline with PBSCT or thalidomide therapy according to patients' age.
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