| Project/Area Number |
20591010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
KUBO Shinichiro Juntendo University, 医学研究科, 准教授 (20327795)
|
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| Co-Investigator(Kenkyū-buntansha) |
服部 信孝 順天堂大学, 医学部, 教授 (80218510)
|
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 家族性パーキンソン病 / lipid rafts / LRRK2 / PINK1 / Parkin / DJ-1 / 膜輸送 |
|---|
| Research Abstract |
It is unknown how mutant proteins responsible for familial Parkinson's disease result in nigral degeneration as well as where these protein localize in neuronal cells. We have revealed that LRRK2, in addition to alpha-synuclein and parkin, associates with lipid rafts, microdomains of cell membranes which play important roles in signal transduction and membrane trafficking in the cell. We have, furthermore, found membrane-binding potentials of DJ-1 and PINK1 proteins.
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