| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Using simultaneous staining of four chemokine receptors, we identified a unique T cell population increased in the cerebrospinal fluid of patients with relapsing multiple sclerosis. CCR2+CCR5+ T cells were selectively enriched in the cerebrospinal fluid of multiple sclerosis patients but not of patients with other inflammatory and non-inflammatory neurological diseases. We found that CCR2+CCR5+ T cells from peripheral blood of multiple sclerosis patients in relapse specifically responded to myelin basic protein and produced both interferon-γ and interleukin-17. Of note, we demonstrated that the CCR2+CCR5+ population possesses a distinct ability to produce matrix metalloproteinase-9 and osteopontin, both of which are thought to be crucial for the invasion into the parenchyma. We propose that the CCR2+CCR5+ T cells may play a role in triggering brain autoimmune inflammation.
|
