Pathological studies on Parkinson's disease and amyotrophic lateral sclerosis
Project/Area Number |
20591017
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Gunma University |
Principal Investigator |
OKAMOTO Koichi Gunma University, 大学院・医学系研究科, 教授 (00124652)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 筋萎縮性側索硬化症 / パーキンソン病 / 前頭側頭葉変性症 / α-synuclein / TDP-43 / FUS / optineurin / peripherin / パーキンソニズム / Bunina小体 / Golgi装置 / アルツハイマー病 / autophagy / 顆粒空胞変性 / ubiquitin / tyrosine hydroxylase. |
Research Abstract |
In our 204 consecutive autopsied cases, there were close relationship between α-synuclein pathology in dorsal vagal nuculei and the decrease of tyrosine hydroxylase immunorectivites in cardiac sympathetic nerves. We reported FUS pathology in various amyotrophic lateral sclerosis (ALS) types, clinical and neuropathological findings of Japanese familial ALS patients with a novel TDP-43 A315E mutation, presence of several peripherin-positive Bunina bodies, and appearance of optineurin not only in ALS but also in many neurodegenerative conditions.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] A Japanese ALS6 family with mutation R521C in the FUS/TLS gene : a clinical, pathological and genetic report.2010
Author(s)
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
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Journal Title
J Neurol Sci 296(1-2)
Pages: 59-63
Related Report
Peer Reviewed
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[Journal Article] A Japanese ALS6 family with mutation R521C in the FUS/TLS gene : a clinical, pathological and genetic report2010
Author(s)
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
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Journal Title
J Neurol Sci
Volume: 296
Pages: 59-63
Related Report
Peer Reviewed
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[Journal Article] Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology2009
Author(s)
Ikeda M, Harigaya Y, Kawarabayashi T, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M
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Journal Title
Brain Res 1250
Pages: 232-241
Related Report
Peer Reviewed
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[Journal Article] Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pat hology2009
Author(s)
Ikeda M, Hiragaya Y, Kawarabayashi T, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, lieda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M
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Journal Title
Brain Res 1250
Pages: 232-241
Related Report
Peer Reviewed
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[Journal Article] TDP-43 mutation in familial amyotrophic lateral sclerosis.2008
Author(s)
Yokoseki A, Shiga A, Tan-C-F, Tagawa A, Kaneko H, Koyama A, Eguchi H, Tsujino A, Ikeuchi T, Kakita A, Okamoto K, Nishizawa M, Takahashi H, Onodera O
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Journal Title
Ann Neurol 63(4)
Pages: 538-542
Related Report
Peer Reviewed
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[Journal Article] TDP-43 mutation in familial amyotrophic lateral sclerosis2008
Author(s)
Yokoseki A, Shiga A, Tan-C-F, Tagawa A, Kaneko H, Koyama A, Eguchi H, Tsujino A, Ikeuchi T, Kakita A, Okamoto K, Ni shizawa M, Takahashi H, Onodera 0
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Journal Title
Ann Neurol 63
Pages: 538-542
Related Report
Peer Reviewed
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[Presentation] Motor Neuron disease with FUS pathology2010
Author(s)
Fujita Y, Fujita S, Takatama M, Aizawa H, Mihara B, Watanabe M, Ikeda M, Okamoto K
Organizer
BRI International Symposium 2010. Current Und erstandings and Future Directions For ALS
Place of Presentation
新潟大学(新潟県)
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[Presentation] ALS6の臨床遺伝および病理学的検討2010
Author(s)
渡辺光法, 岡本幸市, 池田将樹, 中里洋一, 渡辺有希子, 白濱育美, 高村歩美, 瓦林毅, 松原悦朗, 池田佳生, 若佐谷保仁, 東海林幹夫
Organizer
第51回日本神経病理学会
Place of Presentation
砂防会館別館(東京都)
Related Report
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