The neurophysiological study of the association between K+ channel dysfunction and motor neuronal loss in amyotrophic lateral sclerosis
| Project/Area Number |
20591018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
KANAI Kazuaki Chiba University, 医学部附属病院, 助教 (10375751)
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| Co-Investigator(Kenkyū-buntansha) |
KUWABARA Satoshi 千葉大学, 大学院・医学研究院, 教授 (70282481)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 筋萎縮性側索硬化症 / チャネロパチー / 神経軸索興奮特性 / ナトリウムチャネル / カリウムチャネル / 神経変性 / 神経保護 / チェネロパチー |
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| Research Abstract |
We estimated simultaneously the changes of motor axonal excitability properties and nodal/paranodal ion channel expressions of Na+ and K+ channels in the process of the Wallerian degeneration and regeneration in mice model, and reported the association among them. We also studied the nerve excitability changes in the motor neuron diseases and its associations with the disease pathophysiology, and studied the pathophysiological roles of channelopathy in some neurological disorders. The results were presented in some symposiums and conferences, and were published in some papers.
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Report
(4 results)
Research Products
(48 results)
