Analysis of the aquaporin expression in skeletal muscles with neuromuscular diseases.
| Project/Area Number |
20591020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Jun The University of Tokyo, 医学部附属病院, 講師 (40260492)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経筋疾患 / aquaporin 4 / aquaporin / 筋線維 |
|---|
| Research Abstract |
Aquaporin 4 (AQP4) is known to be important not only in controlling water balance of many cell types but also serve as an autoimmune target of neuromyelitis optica. In this project, we studied AQP4 expression of skeletal muscle fibers in various neuromusclular diseases including inflammatory myopathies. In immunohistochemistry, in addition to regenerating muscle fibers and denervated muscle fibers irrespective of disease, many non necrotic fibers in inflammatory myopathies showed the decrease of AQP4 expression. In the analysis of the factors which correlates to the decrease of AQP4 expression, the deposit of membrane attack complex (C5b9) in muscle tissues was clearly correlated. Our findings indicated that the activation of complement cascade decreases the AQP4 expression in skeletal muscle fibers in inflammatory myopathies, and causes functional defect of skeletal muscle fibers in inflammatory myopathies.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum.2010
Author(s)
Shimizu J, Hatanaka Y, Hasegawa M, Iwata A, Sugimoto I, Date H, Goto J, Shimizu T, Takatsu M, Sakurai Y, Nakase H, Uesaka Y, Hashida H, Hashimoto K, Komiya T, Tsuji S
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Journal Title
Neurology. 75
Pages: 1423-142
Related Report
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[Journal Article] IFN β-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum.2010
Author(s)
Shimizu J, Hatanaka Y, Hasegawa M, Iwata A, Sugimoto I, Date H, Goto J, Shimizu T Takatsu M, Sakurai Y, Nakase H, Uesaka Y, Hashida H, Hashimoto K, Komiya T, Tsuji S.
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Journal Title
Neurology
Volume: 75
Pages: 1423-1427
Related Report
Peer Reviewed
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