Dynamics of human language and motor networks under normal and pathological conditions
| Project/Area Number |
20591022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUMOTO Riki Kyoto University, 医学研究科, 助教 (00378754)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Akio 京都大学, 医学研究科, 准教授 (90212761)
MIKUNI Nobukuni 京都大学, 医学研究科, 准教授 (60314217)
SAWAMOTO Nobukatsu 京都大学, 医学研究科, 助教 (90397547)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高次脳機能連関 / 言語 / 行為 / 皮質間ネットワーク / 機能動態 / 機能的結合性 / ネットワーク / 皮質電気刺激 / 誘発電位 / 標準脳 / てんかん / 硬膜下電極 / MRI / 拡散強調画像 / 皮質間結合 |
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| Research Abstract |
Despite advancement of functional cortical mapping in the last decade, little is known about cortico-cortical networks involved in higher cognitive functions in humans. By combining diffusion tractography and invasive electrical tract tracing method of cortico-cortical evoked potentials (CCEPs), we delineated cortico-cortical networks related with language and praxis functions. We also clarified dynamics of the network involved in reading and possible reorganization of the language network in conjunction with pathology. We constructed the standardized parieto-frontal CCEP connectivity map in attempt to feedback our findings into the system neuroscience.
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study.2011
Author(s)
Matsumoto R, Imamura H, Inouchi M, Nakagawa T, okoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
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Journal Title
Neuropsychologia. 49(5)
Pages: 1350-1354
NAID
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[Journal Article] Negative motor seizure arising from negative motor area : is it ictal apraxia?2009
Author(s)
Ikeda A, Hirasawa K, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki J, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
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Journal Title
Epilepsia 50(9)
Pages: 2072-84
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[Journal Article] Hemispheric asymmetry of the arcuate fasciculus. A preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test.2008
Author(s)
Matsumoto R, Okada T, Mikuni N, Mitsueda T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
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Journal Title
J Neurol 255(11)
Pages: 1703-11
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[Journal Article] Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy.
Author(s)
Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M, Matsuhashi M, Nagamine T, Shibasaki H, Takahashi R
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Journal Title
NAID
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[Presentation] Parieto-frontal network in praxis of human : a combined study of high frequency cortical stimulation and CCEP study.2010
Author(s)
Shimotake A, Matsumoto R, Fumuro T, Inouchi M, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
Organizer
ICCN 2010
Place of Presentation
Kobe, Japan
Year and Date
2010-11-01
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