| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
In basal ganglia disorders, it is essential to clarify 'network dysfunction' in order to understand pathophysiological mechanisms from neuronal cell degeneration to clinical symptoms. Since the basal ganglia have no direct motor output, the network dysfunction should results in disordered outputs from the motor cortex reflecting the clinical symptoms. The present studies suggest that compensatory function of the cerebellum as well as disrupted function of cortico-basal ganglia loop should be considered in pathophydiological mechanisms of Parkinson disease.
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