| Project/Area Number |
20591026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMASAKI Takao Kyushu University, 医学研究院, 特任助教 (70404069)
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| Co-Investigator(Kenkyū-buntansha) |
OHYAGI Yasumasa 九州大学, 医学研究院, 准教授 (30301336)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 軽度認知機能障害 / アルツハイマー病 / 認知症 / 事象関連電位 / 視覚誘発電位 / 機能的MRI / マルチモーダル視覚刺激 / サブタイプ / 軽度認知機能障害(MCI) / アルツハイマー病(AD) / 事象関連電位(ERP) / 視覚誘発電位(VEP) / 機能的MRI(fMRI) |
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| Research Abstract |
By using visual evoked potentials, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) with multimodal visual stimuli, we investigated the difference in the brain response among healthy young adults, old adults and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). As results, we found that ERP and fMRI responses for motion stimuli were significantly decreased in patients with MCI and AD compared to healthy old adults. Therefore, ERP and fMRI responses for motion stimuli are the most useful for early detection of MCI non-invasively.
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