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Research on somatosensory cortical responses by the electromagnetic recording method

Research Project

Project/Area Number 20591027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionAomori University of Health and Welfare

Principal Investigator

OZAKI Isamu  Aomori University of Health and Welfare, 健康科学部, 教授 (90241463)

Research Collaborator HASHIMOTO Isao  金沢工業大学, 客員教授
KIMURA Tomoaki  東京有明医療大学, 保健医療学部, 准教授 (50269289)
IGUCHI Yoshinobu  東京都医学総合研究所, ヒト統合脳機能プロジェクト, 研究員 (10342916)
TAKINO Ryosuke  白梅学園大学, 子ども学部, 教授 (50197240)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経科学 / 脳磁界計測 / 高周波信号 / 体性感覚皮質 / 視床皮質線維 / 体部位再現地図 / 体再現地図
Research Abstract

Somatosensory cortical responses following electrical stimulation to the median nerve or finger were studied non-invasively by the electromagnetic recording method. We, for the first time, succeeded in visualizing impulse propagations along the fibers from the thalamus to the somatosensory cortex with the mean conduction velocity of 29 m/s. Also, we have shown that the 600 Hz high frequency oscillations (HFOs), overlying initial cortical activity, reflect the function of inhibitory interneurons as the initial step of somatosensory information processing in the primary somatosensory cortex.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009 2008

All Journal Article (27 results) (of which Peer Reviewed: 13 results) Presentation (24 results) Book (7 results)

  • [Journal Article] 注意の焦点の脳内表現:体性感覚野と聴覚野における短期可塑性2011

    • Author(s)
      井口義信、尾崎勇、橋本勲
    • Journal Title

      認知神経科学 13(1)

      Pages: 1-14

    • NAID

      130006895680

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 機械的触覚逸脱刺激によるミスマッチ反応~MEGを用いた検討~2011

    • Author(s)
      木村友昭, 尾崎勇, 多喜乃亮介, 井口義信, 橋本勲
    • Journal Title

      日本生体磁気学会誌 24(1)

      Pages: 206-207

    • Related Report
      2010 Final Research Report
  • [Journal Article] Missing fundamental のピッチを聴くときには、聴覚皮質の活動が遷延する2011

    • Author(s)
      多喜乃亮介, 尾崎勇, 木村友昭, 井口義信, 橋本勲
    • Journal Title

      日本生体磁気学会誌 24 (1)

      Pages: 188-189

    • Related Report
      2010 Final Research Report
  • [Journal Article] 触覚の周波数判別を妨害する聴覚雑音入力の抑制2011

    • Author(s)
      井口義信, 星詳子, 多喜乃亮介, 木村友昭, 黄田育宏, 尾崎勇, 橋本勲
    • Journal Title

      日本生体磁気学会誌 24(1)

      Pages: 208-209

    • Related Report
      2010 Final Research Report
  • [Journal Article] Exploring the physiology and function of highfrequency oscillations (HFOs) from the somatosensory cortex.2011

    • Author(s)
      尾崎勇, 橋本勲
    • Journal Title

      Clinical Neurophysiology (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] 注意の焦点の脳内表現:体性感覚野と聴覚野における短期可塑性2011

    • Author(s)
      井口義信、尾崎勇、橋本勲
    • Journal Title

      認知神経科学

      Volume: 13(1)(印刷中) Pages: 1-14

    • NAID

      130006895680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機械的触覚逸脱刺激によるミスマッチ反応~MEGを用いた検討~2011

    • Author(s)
      木村友昭, 尾崎勇, 多喜乃亮介, 井口義信, 橋本勲
    • Journal Title

      日本生体磁気学会誌

      Volume: 24(印刷中)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Missing fundamentalのピッチを聴くときには、聴覚皮質の活動が遷延する2011

    • Author(s)
      多喜乃亮介, 尾崎勇, 木村友昭, 井口義信, 橋本勲
    • Journal Title

      日本生体磁気学会誌

      Volume: 24(印刷中)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 触覚の周波数判別を妨害する聴覚雑音入力の抑制2011

    • Author(s)
      井口義信, 星詳子, 多喜乃亮介, 木村友昭, 黄田育宏, 尾崎勇, 橋本勲
    • Journal Title

      日本生体磁気学会誌

      Volume: 24(印刷中)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Exploring the physiology and function of high-frequency oscillations (HFOs) from the somatosensory cortex.2011

    • Author(s)
      Ozaki I, Hashimoto I
    • Journal Title

      Clinical Neurophysiology

      Volume: (submitted 掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency transcutaneous electrical nerve stimulation (TENS) differentially modulates sensorimotor cortices : an MEG study.2010

    • Author(s)
      Murakami T, Takino R, Ozaki I, Kimura T, Iguchi Y, Hashimoto I
    • Journal Title

      Clinical Neurophysiology 121(6)

      Pages: 939-944

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Awareness and somatosensory event-related potentials following near threshold stimuli.2010

    • Author(s)
      Fukushima M, Ozaki I, Kobayashi T, Jung J.
    • Journal Title

      Clinical Neurophysiology 121(7)

      Pages: 22-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency transcutaneous electrical nerve stimulation (TENS) differentially modulates sensorimotor cortices : an MEG study.2010

    • Author(s)
      Murakami T, Takino R, Ozaki I, Kimura T, Iguchi Y, Hashimoto I
    • Journal Title

      Clinical Neurophysiology

      Volume: 121(6) Pages: 939-944

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Awareness and somatosensory event-related potentials following near threshold stimuli.2010

    • Author(s)
      Fukushima M, Ozaki I, Kobayashi T, Jung J
    • Journal Title

      Clinical Neurophysiology

      Volume: 121(7) Pages: 22-22

    • Related Report
      2010 Annual Research Report
  • [Journal Article] High-frequency transcutaneous electrical nerve stimulation (TENS) differentially modulates sensorimotor cortices : an MEG study.2010

    • Author(s)
      Murakami T, Takino R, Ozaki I, Kimura T, Iguchi Y, Hashimoto I
    • Journal Title

      Clinical Neurophysiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency transcutaneous electrical nerve stimulation(TENS)differentially modulates sensorimotor cortices : an MEG study2010

    • Author(s)
      Murakami T, Takino R, Ozaki I, Kimura T, Iguchi Y, Hashimoto I
    • Journal Title

      Clinical Nearophysiology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト体性感覚野からの高周波振動と臨床応用2009

    • Author(s)
      尾崎勇, 橋本勲
    • Journal Title

      臨床検 53(9)

      Pages: 1041-1048

    • Related Report
      2010 Final Research Report
  • [Journal Article] ヒト聴覚野の等周波数帯2009

    • Author(s)
      尾崎勇, 多喜乃亮介, 橋本勲
    • Journal Title

      臨床検査 53(9)

      Pages: 1065-1072

    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] 脳深部白質からの磁場信号の計測2009

    • Author(s)
      木村友昭, 尾崎勇, 橋本勲
    • Journal Title

      臨床検査 53(9)

      Pages: 1079-1083

    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] ヒト大脳白質からの磁場信号の計測2009

    • Author(s)
      木村友昭, 尾崎勇, 橋本勲
    • Journal Title

      日本生体磁気学会誌 22(1)

      Pages: 182-183

    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] ヒト体性感覚野からの高周波振動と臨床応用2009

    • Author(s)
      尾崎勇, 橋本勲
    • Journal Title

      臨床検査 53(9)

      Pages: 1041-1048

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] Dynamic movement of N100m current sources in auditory evoked fields : Comparison of ipsilateral versus contralateral responses in human auditory cortex.2008

    • Author(s)
      Jin CY, Ozaki I, Suzuki Y, Baba M, Hashimoto I
    • Journal Title

      Neuroscience Research 60

      Pages: 397-405

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impulse Propagation along thalamocortical fibers can be detected magnetically outside the human brain.2008

    • Author(s)
      木村友昭, 尾崎勇, 橋本勲
    • Journal Title

      Journal of Neuroscience 28(47)

      Pages: 12535-12538

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 後角病変と後索病変の鑑別におけるSEPの有用性2008

    • Author(s)
      高田博仁, 尾崎勇
    • Journal Title

      頸髄症例の検討から.臨床脳波 50(1)

      Pages: 10-17

    • Related Report
      2010 Final Research Report
  • [Journal Article] 体性感覚誘発電位(SEP)の臨床応用2008

    • Author(s)
      尾崎勇, 鈴木千恵子
    • Journal Title

      臨床神経生理学 36

      Pages: 145-160

    • NAID

      10027055643

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic movement of N100m current sources in auditory evoked fields : Comparison of ipsilateral versus contralateral responses in human auditory cortex2008

    • Author(s)
      Jin CY, Ozaki I, Suzuki Y, Baba M, Hashimoto I
    • Journal Title

      Neuroscience Research 60

      Pages: 397-405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impulse Propagation along Thalamocortical Fibers Can Be Detected Magnetically outside the Human Brain2008

    • Author(s)
      木村友昭, 尾崎勇, 橋本勲
    • Journal Title

      Journal of Neuroscience 28(47)

      Pages: 12535-12538

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fast pain 刺激に伴う自律神経活動の変化について2010

    • Author(s)
      斉藤優子, 岩部達也, 尾崎勇
    • Organizer
      第46回脊髄・末梢神経・筋疾患懇話会
    • Place of Presentation
      青森県青森市(ホテル青森)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Fast pain刺激に伴う自律神経活動の変化について2010

    • Author(s)
      斉藤優子, 岩部達也, 尾崎勇
    • Organizer
      第46回脊髄・末梢神経・筋疾患懇話会
    • Place of Presentation
      青森県青森市(ホテル青森)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Magnetic fields of the human brain accompanying voluntary finger movement : in comparison with fMRI and NIRS.2010

    • Author(s)
      尾崎勇
    • Organizer
      日英ワークショップ:脳機能に関するマルチモーダル計測(英国大使館主催)
    • Place of Presentation
      東京都千代田区(英国大使館新館ニューホール)
    • Related Report
      2010 Final Research Report
  • [Presentation] 閾値レベルの体性感覚刺激による事象関連脳電位2010

    • Author(s)
      尾崎勇, 福島真人, 小林哲生, 鄭址旭
    • Organizer
      第9回釧路ニューロサイエンスワークショップ
    • Place of Presentation
      北海道釧路市(釧路プリンスホテル)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脳磁図研究~最近の話題~.ワークショップ3「夢と理想の Multimodal Imaging」2010

    • Author(s)
      尾崎勇
    • Organizer
      第27回日本脳電磁図トポグラフィ研究会(JSBET)
    • Place of Presentation
      宮城県松島町(ホテル松島大観荘)
    • Related Report
      2010 Final Research Report
  • [Presentation] Human tonotopic maps studied by magnetoencephalography. Symposium S15. Auditory system2010

    • Author(s)
      尾崎勇
    • Organizer
      第29回国際臨床神経生理学会 (ICCN2010, 29^<th> International Congress of Clinical Neurophysiology)
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Final Research Report
  • [Presentation] Awareness and somatosensory event-related potentials following near threshold stimuli.2010

    • Author(s)
      Fukushima M, Ozaki I, Kobayashi T, Jung J.
    • Organizer
      第29回国際臨床神経生理学会 (ICCN2010, 29^<th> International Congress of Clinical Neurophysiology)
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Final Research Report
  • [Presentation] Subjective distinctness of tactile sensation is represented in the activity of human secondary somatosensory cortex (SII)2010

    • Author(s)
      坪川恒久, 橋本勲
    • Organizer
      第29回国際臨床神経生理学会 (ICCN2010, 29^<th> International Congress of Clinical Neurophysiology)
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳磁図研究~最近の話題~2010

    • Author(s)
      尾崎勇
    • Organizer
      第27回日本脳電磁図トポグラフィ研究会(JSBET)
    • Place of Presentation
      宮城県松島町(ホテル松島大観荘)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Human tonotopic maps studied by magnetoencephalography.2010

    • Author(s)
      Ozaki I
    • Organizer
      ICCN2010, 29^<th> International Congress of Clinical Neurophysiology
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Awareness and somatosensory event-related potentials following near threshold stimuli.2010

    • Author(s)
      Fukushima M, Ozaki I, Kobayashi T, Jung J.
    • Organizer
      ICCN2010, 29^<th> International Congress of Clinical Neurophysiology
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Subjective distinctness of tactile sensation is represented in the activity of human secondary somatosensory cortex (SII).2010

    • Author(s)
      Iguchi Y, Y.Hoshi Y, Takino R, Kimura T, Ozaki I, Kida I, Tsubokawa T, Hashimoto I
    • Organizer
      ICCN2010, 29^<th> International Congress of Clinical Neurophysiology
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Magnetic fields of the human brain accompanying voluntary finger movement : in comparison with fMRI and NIRS2010

    • Author(s)
      Ozaki I
    • Organizer
      日英ワークショップ:脳機能に関するマルチモーダル計測(英国大使館主催)
    • Place of Presentation
      東京都千代田区(英国大使館新館ニューホール)
    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Presentation] 大脳白質からの磁場信号の計測2009

    • Author(s)
      木村友昭, 尾崎勇, 橋本勲
    • Organizer
      第24回日本生体磁気学会大会
    • Place of Presentation
      石川県金沢市(金沢市文化ホール)
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2008 Annual Research Report
  • [Presentation] Visual-evoked magnetic fields in early stage of Alzheimer's disease : An optic flow stimulation study.2009

    • Author(s)
      Kikuchi M, Tsubokawa T, Ozaki I, Minabe Y, Hashimoto I
    • Organizer
      第18回国際脳電磁図ポグラフィ研究会議 ISBET 2009
    • Place of Presentation
      京都府京都市(京都市国際交流会館)
    • Related Report
      2010 Final Research Report
  • [Presentation] 体性感覚野の高周波振動(HFOs)について. 「シンポジウム21:大脳感覚野・運動野の内因性リズムの意味:高周波振動(HFOS)」2009

    • Author(s)
      尾崎勇
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市(北九州国際会議場,西日本総合展示場)
    • Related Report
      2010 Final Research Report
  • [Presentation] 体性感覚刺激への気づきと誘発電位2009

    • Author(s)
      福島真人, 尾崎勇, 小林哲生, 鄭址旭
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市(北九州国際会議場,西日本総合展示場)
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Visual-evoked magnetic fields in early stage of Alzheimer's disease : An opticflow stimulation study.2009

    • Author(s)
      Kikuchi M, Tsubokawa T, Ozaki I, Minabe Y, Hashimoto I
    • Organizer
      第18回国際脳電磁図トポグラフィ研究会議ISBET 2009,第26回日本脳電磁図トポグラフィ研究会(JSBET)
    • Place of Presentation
      京都市(京都市国際交流会館)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体性感覚野の高周波振動(HFOs)について(シンポジウム21:大脳感覚野・運動野の内因性リズムの意味:高周波振動(HFO_s)に関連して)2009

    • Author(s)
      尾崎勇
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市(北九州国際会議場,西日本総合展示場)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visual-evoked magnetic fields in early stage of Alzheimer's disease : An optic flow stimulation study2009

    • Author(s)
      Kikuchi M, Tsubokawa T, Ozaki I, Minabe Y, Hashimoto I
    • Organizer
      第18回国際脳電磁図トポグラフィ研究会議ISBET 2009, 第26回日本脳電磁図トポグラフィ研究会(JSBET)
    • Place of Presentation
      京都市(京都市国際交流会館)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体性感覚野の高周波振動(HFOs)について(シンポジウム21:大脳感覚野・運動野の内因性リズムの意味:高周波振動(HFOs)に関連して)2009

    • Author(s)
      尾崎勇
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市(北九州国際会議場, 西日本総合展示場)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体性感覚刺激への気づきと誘発電位2009

    • Author(s)
      福島真人, 尾崎勇, 小林哲生, 鄭址旭
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市(北九州国際会議場, 西日本総合展示場)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低酸素脳症の体性感覚誘発電位~中潜時成分と予後についての検討2008

    • Author(s)
      鈴木千恵子, 尾崎勇, 冨山誠彦, 瓦林毅, 東海林幹夫
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      神奈川県横浜市(パシフィコ横浜)
    • Related Report
      2010 Final Research Report
  • [Presentation] 仮現運動刺激を用いた視角誘発磁場に現われる加齢変化2008

    • Author(s)
      上野沙奈絵, 菊知充, 坪川恒久, 川渕泰之, 下道喜代美, 尾崎勇, 橋本勲
    • Organizer
      第38回日本臨床神経生理学会学術大会
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Related Report
      2010 Final Research Report
  • [Book] ガイトン生理学(原書第11版,御手洗玄洋 総監訳)(第5章静止膜電位と活動電位) ISBN 978-4-86034-724-62010

    • Author(s)
      尾崎勇(翻訳)
    • Total Pages
      1177
    • Publisher
      エルゼビア・ジャパン,東京,
    • Related Report
      2010 Final Research Report
  • [Book] Nagata K (edited): Brain Topography and Multimodal Imaging. Kyoto University Press, ISBN 978-4-87698-799-32009

    • Author(s)
      Kobayashi T, Ozaki I
    • Total Pages
      263
    • Publisher
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Book] (可塑性のメカニズムと神経系の障害)(Aage R. Moller 著)「脳の可塑性」 ISBN 978-4-263-21337-72009

    • Author(s)
      中川雅文, 尾崎勇(監訳)
    • Total Pages
      225
    • Publisher
      医歯薬出版,東京
    • Related Report
      2010 Final Research Report
  • [Book] Brain Topography and Multimodal Imaging.2009

    • Author(s)
      Kobayashi T, Ozaki I, Nagata K(edited)
    • Total Pages
      263
    • Publisher
      Kyoto University Press, Kyoto, Japan ISBN 978-4-87698-799-3,
    • Related Report
      2009 Annual Research Report
  • [Book] 脳の可塑性。可塑性のメカニズムと神経系の障害。2009

    • Author(s)
      中川雅文, 尾崎勇(監訳)(Aage R.Moller著)
    • Total Pages
      225
    • Publisher
      医歯薬出版,東京,ISBN 978-4-263-21337-7
    • Related Report
      2009 Annual Research Report
  • [Book] Brain Topography and Multimodal Imaging2009

    • Author(s)
      Kobayashi T, Ozaki I, Nagata K(edited)
    • Total Pages
      263
    • Publisher
      Kyoto University Press, Kyoto, Japan ISBN 978-4-87698-799-3
    • Related Report
      2008 Annual Research Report
  • [Book] 脳の可塑性。可塑性のメカニズムと神経系の障害2009

    • Author(s)
      中川雅文, 尾崎勇(監訳)(Aage R.Moller著)
    • Total Pages
      225
    • Publisher
      医歯薬出版, 東京, ISBN 978-4-263-21337-7
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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