Evaluation of non-motor symptoms in Parkinson's disease for potential application to early diagnosis

• Project/Area Number: 20591031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Showa University
• Principal Investigator: KAWAMURA Mitsuru Showa University, 医学部, 教授 (20161375)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Hidetomo 昭和大学, 医学部, 講師 (60384476) ; KOBAYAKAWA Mutsutaka 昭和大学, 医学部, 普通研究生 (80445600)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: パーキンソン病 / 非運動症状 / 自律神経機能 / 認知機能 / 早期診断

Research Abstract

We investigated the non-motor symptoms of Parkinson's disease and explored their availability for early diagnosis. Rapid eye movement (REM) sleep behavior disorder (RBD) can be an early symptom of alpha-synucleinopathies including Parkinson's disease. We examined whether the cognitive and autonomic symptoms reported in these conditions also developed in RBD patients. We also examined whether the patients had preclinical nerve degeneration in the nigrostriatal dopaminergic system using dopamine transporter PET. The results were as follows. (1) The dopamine transporter PET indicated the reduced pre-synaptic function in the nigrostriatal dopaminergic system in 2 out of 3 RBD patients. (2) Olfactory recognition and social-cognition including facial-expression recognition and decision-making was impaired in two patients with the reduced pre-synaptic function. (3) Autonomic signs such as decreased myocardial 123I-metaiodobenzylguanidine (MIBG) uptake and constipation were present in all patients. The social-cognitive and autonomic symptoms in the RBD patients were consistent with those of PD patients. Based on the consistence and the reduced pre-synaptic function in the nigrostriatal system, we predicted that motor symptoms may develop in those RBD patients in the near future.

Research Products

• [Journal Article] Is "reading mind in the eys" impaired in Parkinson's disease? (2011)
  • Author(s): Tsuruya N, Kobayakawa M, Kawamura M
  • Journal Title: Parkinsonism & Related Disorders 17 Pages: 246-248
  • Peer Reviewed
• [Journal Article] Sensitivity to reward and punishment in Parkinson's disease : An analysis of behavioral patterns using a modified version of the Iowa Gambling Task. (2010)
  • Author(s): Kobayakawa M, Tsuruya N, Kawamura M
  • Journal Title: Parkinsonism & Related Disorders 16 Pages: 453-457
  • Peer Reviewed
• [Journal Article] パーキンソン病における認知・情動機能 (2010)
  • Author(s): 小早川睦貴、河村満
  • Journal Title: 実験医学 28巻 Pages: 656-660
• [Journal Article] Sensitivity to reward and punishment in Parkinson's disease : An analysis of behavioral patterns using a modified version of the Iowa (2010)
  • Author(s): Kobayakawa M, Tsuruya N, Kawamura M
  • Journal Title: Parkinsonism & Related Disorders Volume: 16 Pages: 453-457
  • Peer Reviewed
• [Journal Article] パーキンソン病における認知・情動機能 (2010)
  • Author(s): 小早川睦貴, 河村満
  • Journal Title: 実験医学 Volume: 28 Pages: 656-60
• [Journal Article] A flexible sequential learning deficit in patients with Parkinson's disease : A2×8 button-Dress task (2010)
  • Author(s): Mochizuki-Kawai H, Mochizuki S, Kawamura M.
  • Journal Title: Experomental Brain Research 202 Pages: 147-53
  • Peer Reviewed
• [Journal Article] パーキンソン病における認知・情動機能 (2010)
  • Author(s): 小早川睦貴, 河村満
  • Journal Title: 実験医学 28 Pages: 656-660
• [Journal Article] パーキンソン病患者さんはギャンブリングを生じやすいか? (2009)
  • Author(s): 小早川睦貴、河村満
  • Journal Title: Frontiers in Parkinson disease 2 Pages: 13-16
• [Journal Article] Emotional impairment in Parkinson's disease. (2009)
  • Author(s): Kawamura M, Kobayakawa M
  • Journal Title: Parkinsonism & Related Disorders 15
• [Journal Article] パーキンソン病患者さんはギャンブリングを生じやすいか? (2009)
  • Author(s): 小早川睦貴, 河村満
  • Journal Title: Frontiers in Parkinson disease 2
• [Journal Article] Overnight switching from ergot-derived dopamine agonists to pramipexole in patients with Parkinson's disease : an open preliminary trial in Japan (2009)
  • Author(s): Ohno H, Nakajima M, Fujioka S, Iwamoto K, Kawamura M.
  • Journal Title: J Clin Neurosci 16 Pages: 790-792
  • Peer Reviewed
• [Journal Article] 神経疾患の新しいパースペクティブ;パーキンソン病の認織能障害 (2009)
  • Author(s): 小早川睦貴
  • Journal Title: 実験医学 69 Pages: 24-30
• [Journal Article] Emotional impairment in Parkinson's disease (2009)
  • Author(s): Kawamura M, Kobayakawa M
  • Journal Title: Parkinsonism&Related Disorders 14(Suppl3)
• [Journal Article] パーキンソン病における認知機能障害 (2008)
  • Author(s): 小早川睦貴, 鶴谷奈津子, 河村満
  • Journal Title: Progress in medicine 18 Pages: 2375-2379
• [Journal Article] Respiratory responses to olfactory stimuli in Parkinson's disease (2008)
  • Author(s): Masaoka Y, Satoh H, Kawamura M, Homma I
  • Journal Title: Respir Physiol Neurobiol 161(2) Pages: 136-141
  • Peer Reviewed
• [Journal Article] Is "reading mind in the eyes" impaired in Parkinson's disease?
  • Author(s): Tsuruya N, Kobayakawa M, Kawamura M
  • Journal Title: Parkinsonism & Related Disorders Volume: (in press)
  • Peer Reviewed
• [Journal Article] Olfaction in Parkinson's disease and aging
  • Author(s): Shimizu Y, Masaoka Y, Kawamura M, Homma I
  • Journal Title: The Showa University Journal of Medical Sciences in press
  • NAID: 130004566483
  • Peer Reviewed
• [Journal Article] Overnight switching from ergot-derived dopamine agonists to pramipexole in patients with Parkinson's disease : An open preliminary trial
  • Author(s): Ohno H, Nakajima M, Fujioka S, Iwamoto K, Kawamura M
  • Journal Title: J Clin Neurosci in press
  • Peer Reviewed
• [Journal Article] Parkinson病における非麦角系ドパミンアゴニスト等価換算の検討
  • Author(s): 村上秀友, 石原健司, 大野英樹, 市川博雄, 河村満
  • Journal Title: 神経内科 in press
  • Peer Reviewed
• [Presentation] パーキンソン病の認知機能障害 (2010)
  • Author(s): 河村満
  • Organizer: 大阪老年・神経疾患治療セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-18
• [Presentation] Mind reading impairment in Parkinson's disease. (2010)
  • Author(s): Tsuruya N, Kobayakawa M, Kawamura M
  • Organizer: International Neuropsychological Society Mid-year Meeting.
  • Place of Presentation: ポーランド
• [Presentation] Infering mental state from eye gaze in Parkinson's disease. (2010)
  • Author(s): Kobayakawa M, Tsuruya N, Murakami H, Kawamura M
  • Organizer: World Federation of Neurology Aphasia and Cognitive Disorders Research Group.
  • Place of Presentation: トルコ
• [Presentation] Mind reading impairment in Parkinson's disease (2010)
  • Author(s): Tsuruya N, Kobayakawa M, Kawamura M.
  • Organizer: International Neuropsychological Society Mid-year Meeting.
  • Place of Presentation: ポーランド
• [Presentation] Infering mental state from eye gaze in Parkinson's disease (2010)
  • Author(s): Kobayakawa M, Tsuruya N, Murakami H, Kawamura M
  • Organizer: World Federation of Neurology Aphasia and Cognitive Disorders Research Group
  • Place of Presentation: トルコ
• [Presentation] SWI sequence might be a diagnostic marker for PD and DLB (2009)
  • Author(s): Inoue M, Nagao I, Iosnizawan Kawamura M, Ida M, Yokochi M, Takubo, H
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: マイアミ
  • Year and Date: 2009-12-13
• [Presentation] パーキンソン病の認知機能障害:特に社会的認知障害について (2009)
  • Author(s): 河村満
  • Organizer: 第14回東北パーキンソン病治療研究会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-14
• [Presentation] Effect of subthalamic deep brain stimulation on emotional cognition in patients with Parkinson's disease (2009)
  • Author(s): Yokochi F, Taniguchi M, Yoshimura N, Kawamura M.
  • Organizer: 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: シカゴ
  • Year and Date: 2009-11-03
• [Presentation] パーキンソン病における心の理論-まなざし課題を用いた検討 (2009)
  • Author(s): 鶴谷奈津子, 小早川睦貴, 河村満
  • Organizer: 第3回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] パーキンソン病における意思決定 ～逆転ギャンブル課題を用いた検討 (2009)
  • Author(s): 小早川睦貴, 鶴谷奈津子, 河村満
  • Organizer: 第33回日本神経心理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Presentation] パーキンソン病における社会的認知機能～行動選択に関する検討～ (2009)
  • Author(s): 小早川睦貴
  • Organizer: 第73回日本心理学会ワークショップ「社会的認知の障害 -社会的認知に果たす皮質下の役割-」
  • Place of Presentation: 京都
  • Year and Date: 2009-08-26
• [Presentation] 行為・意志決定・社会性 ～身体を介したコミュニケーション～ (2009)
  • Author(s): 小早川睦貴, 鶴谷奈津子
  • Organizer: 第11回日本脳機能マッピング学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-28
• [Presentation] パーキンソン病における意思決定～逆転ギャンブル課題を用いた検討 (2009)
  • Author(s): 小早川睦貴、鶴谷奈津子、河村満
  • Organizer: 第33回日本神経心理学会総会
  • Place of Presentation: 東京
• [Presentation] パーキンソン病における他者心理の推測～まなざし課題を用いた検討 (2009)
  • Author(s): 鶴谷奈津子、小早川睦貴、河村満
  • Organizer: 第33回日本神経心理学会総会
  • Place of Presentation: 東京
• [Presentation] Decision-making and Emotional Responses in Parkinson's Disease. (2009)
  • Author(s): Kobayakawa M, Tsuruya N, Kawamura M
  • Organizer: Joint Tamagawa/Caltech Lecture-course on EMOTION.
  • Place of Presentation: パサデナ
• [Presentation] Cognitive, emotional, and autonomic signs in patients with RBD. (2009)
  • Author(s): Kawamura M, Koyama S, Kobayakawa M, Tsuruya N.
  • Organizer: The 9th international conference of Alzheimer's and Parkinson's disease (AD/PD2009)
  • Place of Presentation: Prague
• [Presentation] RBDとPDとを結ぶもの : 認知機能および自律神経機能を中心に (2008)
  • Author(s): 河村満, 小早川睦貴, 小山慎一
  • Organizer: 4th Sleep Symposium in Kansai-Kumamoto
  • Place of Presentation: 熊本
  • Year and Date: 2008-08-02
• [Presentation] パーキンソン病の認知機能障害:最近の話題 (2008)
  • Author(s): 河村満
  • Organizer: 第3回城西城北PDフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-17
• [Presentation] パーキンソン病と扁桃体 (2008)
  • Author(s): 河村満
  • Organizer: 第9回千葉神経難病研究会
  • Place of Presentation: 千葉(特別講演)
  • Year and Date: 2008-04-03
• [Presentation] Emotional responses and decision making performances in Parkinson's disease. (2008)
  • Author(s): Kawamura M, Tsuruya N, Koyama S, Mimura M, Kobayakawa M
  • Organizer: 6th international congress on mental dysfunctions & other non-motor features in Parkinson's disease.
  • Place of Presentation: ドレスデン
• [Presentation] 逆転ギャンブル課題を用いたパーキンソン病における意思決定能力の評価 (2008)
  • Author(s): 小早川睦貴,鶴谷奈津子,武田景敏,河村満
  • Organizer: 第2回Movement Disorders Society Japan.
  • Place of Presentation: 京都
• [Presentation] Decreased Sensitivity to Facial Emotions and Limbic Lesions in Myotonic Dystrophy Type1. (2008)
  • Author(s): Tsuruya N, Takeda A, Kobayakawa M, Kawamura M.
  • Organizer: World Federation of Neurology Aphasia and Cognitive Disorders Research Group.
  • Place of Presentation: エジンバラ
• [Presentation] Emotional responses and decision making performances in Parkinson's disease. (2008)
  • Author(s): Kawamura M, Tsuruya N, KoyamaS, Mimura M, Kobayakawa M.
  • Organizer: The 6th international congress on mental dysfunctions & other non-motor features in Parkinson's disease.
  • Place of Presentation: Dresden
• [Presentation] Prevalence of depression in Parkinson's disease in outpatient clinic (2008)
  • Author(s): Sanada K, Mimura M, Kawamura M, Kobayakawa M, Kato N.
  • Organizer: The 6th international congress on mental dysfunctions & other non-motor features in Parkinson's disease.
  • Place of Presentation: Dresden
• [Presentation] パーキンソン病(PD)におけるロピニロール等価換算の検討(ポスター) (2008)
  • Author(s): 村上秀友, 大野英樹, 石原健司, 市川博雄, 河村満.
  • Organizer: 第49回 日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] 逆転ギャンブル課題を用いたパーキンソン病における意思決定能力の評価 (2008)
  • Author(s): 小早川睦貴, 鶴谷奈津子, 武田景敏, 河村満
  • Organizer: 第2回Movement Disorders Society Japan
  • Place of Presentation: 京都
• [Book] ノンバーバルコミュニケーションと脳-自己と他者をつなぐもの(岩田誠・河村満編)(身体性コミュニケーションとその障害) (2010)
  • Author(s): 小早川睦貴
  • Total Pages: 224
• [Book] ノンバーバルコミュニケーションと脳-自己と他者をつなぐもの(岩田誠・河村満, 編)(身体性コミュニケーションとその障害) (2010)
  • Author(s): 小早川睦貴
  • Total Pages: 224
  • Publisher: 医学書院
• [Book] 社会活動と脳-行動の原点を探る(岩田誠・河村満編)(ギャンブルする脳) (2008)
  • Author(s): 小早川睦貴、河村満
  • Total Pages: 206
• [Book] ギャンブルする脳 〜パーキンソン病における意思決定〜 (書名 : 社会活動と脳) (2008)
  • Author(s): 小早川睦貴, 鶴谷奈津子, 河村満
  • Total Pages: 220
  • Publisher: 医学書院