Relationship between side effects of antiparkinsonian agents and dopaminergic regulatory mechanism of adenosine receptors measured with PET
| Project/Area Number |
20591033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MISHINA Masahiro Nippon Medical School, 医学部, 講師 (70322518)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 正彦 東京慈恵会医科大学, 医学部, 講師 (20266638)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経機能画像学 / パーキンソン病 / PET / アデノシン受容体 / ジスキネジア / 抗パーキンソン病薬 / 副作用 / 被殻 / アデノシンA1受容体 / アデノシンA2A受容体 / 睡眠発作 / ドパミン / アデノシンA_1受容体 / アデノシンA_<2A>受容体 |
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| Research Abstract |
Adenosine A^<2A> receptors (A2ARs) are thought to interact negatively with the dopamine D_2 receptor (D2R). We developed PET ligands for mapping adenosine receptors, and we successfully visualized A2ARs with ^<11>C-TMSX. In this study, we investigated A2ARs in the striata of drug-naive PD patients and PD patients with dyskinesia using ^<11>C-TMSX PET. Our study demonstrated that the A2ARs in the putamen were increased in the PD patients with dyskinesia, and also suggested that the A2ARs in the putamen compensate for the asymmetrical decrease of dopamine in drug-naive PD patients and that antiparkinsonian therapy increases the A2ARs in the putamen. The A2ARs may play an important role in regulation of parkinsonism in PD.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Adenosine A2A Receptors Measured with [<11>^C]TMSXPET in the Striata of Parkinson's Disease Patients.2011
Author(s)
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii k
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Journal Title
PLoS One 6 : e17338
Pages: 1-8
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[Presentation] Comparison of putaminal adenosine A_<2A> receptors in de novo Parkinson's disease with in normals A TMSX PET study.2009
Author(s)
Mishina M, Ishii K, Kitamura S,Naganawa M, Kimura Y, Hashimoto M, Suzuki M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kim K, Kobayashi S, Katayama Y, Ishiwata K
Organizer
The 39th Annual Meeting of the Society For Neuroscience
Place of Presentation
Chicago
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[Presentation] Variations in adenosine A_<2A> receptors following anti-parkinsonian therapy indrug nave Parkinson's disease using <11>^C-TMSX PET.2008
Author(s)
Mishina M, Ishii K, Kitamura S,Kimura Y, Naganawa M, Hashimoto M, Suzuki M, Oda K, Hamamoto M, Kobayashi S, Katayama Y, Ishiwata K
Organizer
The Movement Disorder Society's 12th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
Chicago
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