Clinical and molecular pathological study of hippocampal scleroticdementia as mild cognitive impairment.
| Project/Area Number |
20591034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
YAMAZAKI Mineo Nippon Medical School, 医学部, 准教授 (10277577)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 軽度認知障害 / 認知症 / 海馬硬化 / タウ / TDP-43 |
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| Research Abstract |
In order to clarify the pathomechanism of hippocampal dementia, we examined the selective loss of hippocampal neurons, which was not thought to be caused ischemia. Immunohistochemical study using anti-non-phosphorylated TDP-43 polyclonal antibodies was performed on the hippocampus in cases with Alzheimer's disease, in which cerebellar Purkinje cells were well preserved but hippocampal CA1 neurons were disappeared without ghost tangles. This indicated that decreased neuronal nuclear TDP-43 immunostaining had no relation with neurofibrillary tangles and neuronal cell loss. The pathological mechanism of hippocampal dementia, which was not suffering from ischemia and convulsion, should be examined more precisely.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke.2010
Author(s)
Katsumata T, Otori T, Nishiyama Y, Okubo S Nishiyama Y, Nagayama H, Ueda M, Utsumi K, Yamazaki M, Komaba Y, Katsura K, Katayama Y
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Journal Title
Neurol Sci. 32
Pages: 743-747
Related Report
Peer Reviewed
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[Presentation] ALS of Guam : neuropathological reevaluation in comparison with the parkinsonism-dementia complex, frontotemporal lober degeneration and classic ALS.2010
Author(s)
Oyanagi K, Hashimoto T, Yamazaki M, Hasegawa M, Arai T,Akiyama H, Tsuchiya K, Morita T, Mizutani T, Kakita A, Takahashi H.
Organizer
XVIIth International Congress of Neuropathology (ICN 2010)
Place of Presentation
Salzburg Austria
Related Report
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