Evaluation of matrix metalloproteinase inhibitors for the therapy for muscular dystrophy
| Project/Area Number |
20591035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Teikyo University of Science & Technology |
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Principal Investigator |
HAGIWARA Hiroki Teikyo University of Science & Technology, 医療科学部, 教授 (80276732)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Fumiaki 帝京大学, 医学部, 助教 (40286993)
MATSUMURA Kiichirou 帝京大学, 医学部, 准教授 (50260922)
SHIMIZU Teruo 帝京大学, 医学部, 教授 (00107666)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マトリックスメタロプロテアーゼ / ジストログリカン / 筋ジストロフィー / モデル動物 / 神経科学 / ヒストン脱アセチル化酵素阻害薬 / ヒストン脱アセチル化酵素阻害剤 |
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| Research Abstract |
We studied whether matrix metalloproteinase inhibitors (MMPIs) are effective for the therapy for muscular dystrophy at first. We showed that histone deacetylase inhibitors (HDACIs) promote myotube formation more efficiently than MMPIs. However, its exact mechanism remains unknown. We found that TSA enhances myogenesis by coordinating myogenic regulatory factors and transcriptional repressor.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article]2009
Author(s)
萩原宏毅
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Journal Title
5.筋強直性ジストロフィー.神経疾患最新の治療2009-2011(小林祥泰,水澤英洋編集)(南江堂)
Pages: 306-308
Related Report
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