| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The purpose of this study was to investigate the pathophysiological mechanism of focal dystonia with Positron Emission Tomography and Magnetic Resonance Imaging for the development of effective treatment. We examined the brains of essential blepharospasm (EBS) patients and found that the dopamine D_2 receptor density was declined, the glucose metabolism in the thalamus was elevated in patients with photophobia, Adenosine A_1 receptor density was unremarkable in the striatum, and the gray matter density in the primary sensory-motor cortex in the face region was increased. These findings suggest the functional abnormality in the brain of focal dystonia patients.
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