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Age-associated changes in metabolic responses and the regulatory system.

Research Project

Project/Area Number 20591040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionTohoku University

Principal Investigator

NONOGAKI Katunori  Tohoku University, 未来医工学治療開発センター, 教授 (60370988)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords代謝 / 加齢 / 絶食 / 体重 / 脂肪 / Social Isolation / グレリン / エンドルフィン / SGK1
Research Abstract

Social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. Under the same housing condition, genetic deletion of beta-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of beta-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of beta-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice. Despite no changes in plasma des-acyl ghrelin and the expression of hypothalamic neuropeptide Y and proopiomelanocortin, plasma active ghrelin levels and the expression of hypothalamic SGK-1 were increased in the acute-isolated C57BL6J mice. Injection of SGK-1 small interfering RNA oligonucleotide into the third cerebral ventricle suppressed the acute social isolation-induced decreases in body weight and increases in plasma active ghrelin levels. Pretreatment with phentolamine significantly suppressed the decreases in body weight. These finding suggest that hypothalamic SGK-1 contributes to the isolation stress-induced body weight reductions and increases in plasma active ghrelin levels via, at least partly, altered central autonomic outflow in mice.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (4 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Contribution of central SGK-1 to the acute phase responses of mice to social isolation2010

    • Author(s)
      Kaji T, Nonogaki K.
    • Journal Title

      Frontiers in Bioscience (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic orexin and proopiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice2010

    • Author(s)
      Nonogaki K, Kaji T.
    • Journal Title

      Int.J.Neuropsychopharmacol. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of central SGK-1 to the acute phase responses of mice to social isolation2010

    • Author(s)
      Kaji T, Nonogaki K
    • Journal Title

      Frontiers in Bioscience (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Modulators for body weight changes induced by fasting and re-feeding in mice2009

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Wakameda M, Tamari T
    • Journal Title

      Biochem Biophys Res Commun. 378

      Pages: 249-254

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice2009

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Oka Y.
    • Journal Title

      Biochem Biophys Res Commun. 386

      Pages: 311-315

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluvoxamine exerts anorexic effect in 5-Ht2C receptor mutant mice with heterozygous mutation of beta-endorphin gene2009

    • Author(s)
      Nonogaki K, Ohba Y, wakameda M, Tamari T
    • Journal Title

      Int.J.Neuropsychopharmacol. 12

      Pages: 547-552

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel Modulators for body weight changes induced by fasting and re-feeding in mice.2009

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Wakameda M, Tamari T
    • Journal Title

      Biochem Biophys Res Commun. 378

      Pages: 249-254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin 5-HT2C receptor-independent expression of hypothalamio NOR1, a novel modulator of food intake and energy balance, in mice.2009

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Oka Y.
    • Journal Title

      Biochem Biophys Res Common. 386

      Pages: 311-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene2009

    • Author(s)
      Nonogaki K, Ohba Y, Wakameda M, Tamari T
    • Journal Title

      Int.J.Neuropsychapharmacol. 12

      Pages: 547-552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Modulators for body weight changes induced by fasting andre-feeding in mice2009

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Wakameda M, Tamari T
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 249-254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene2008

    • Author(s)
      Nonogaki K, Ohba Y, Wakameda M, Tamari T
    • Journal Title

      Int J Neuropsychopharmacol. 12

      Pages: 547-552

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice2008

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Oka Y.
    • Journal Title

      Biochem Biophys Res Commun. 372

      Pages: 186-190

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin and feedback systems2008

    • Author(s)
      Nonogaki K
    • Journal Title

      Vitam Horm. 77

      Pages: 149-170

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin and noradrenalin uptake inhibitors and appetite regulation : The role of the central 5-HT network2008

    • Author(s)
      Nonogaki K
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 8

      Pages: 303-310

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene2008

    • Author(s)
      Nonogaki K, Ohba Y, Wakameda M, Tamari T
    • Journal Title

      Int J Neuropsychopharmacol 12

      Pages: 547-552

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice2008

    • Author(s)
      Nonogaki K, Ohba Y, Sumii M, Oka. Y.
    • Journal Title

      Biochem Biophys Res Commun 372

      Pages: 186-190

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin and feedback systems2008

    • Author(s)
      Nonogaki K
    • Journal Title

      Vitam Horm 77

      Pages: 149-170

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中高年肥満・2型糖尿病患者に対するフォーミュラ食の介入効果2009

    • Author(s)
      野々垣勝則
    • Organizer
      日本肥満症治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Social isolation と加齢によるエネルギー代謝の変化2009

    • Author(s)
      野々垣勝則
    • Organizer
      臨床フリーラジカル会議
    • Place of Presentation
      京都
    • Year and Date
      2009-04-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Social isolationと加齢によるエネルギー代謝の変化2009

    • Author(s)
      勝々垣勝則
    • Organizer
      臨床フリーラジカル会議
    • Place of Presentation
      京都
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Social isolationと加齢によるエネルギー代謝の変化2008

    • Author(s)
      野々垣勝則
    • Organizer
      日本糖尿病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波照射装置2010

    • Inventor(s)
      野々垣勝則
    • Industrial Property Rights Holder
      野々垣勝則
    • Industrial Property Number
      2010-083953
    • Filing Date
      2010-03-31
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Patent(Industrial Property Rights)] 超音波発生装置2009

    • Inventor(s)
      野々垣勝則
    • Industrial Property Rights Holder
      野々垣勝則・(有) 三輪サイエンス研究所
    • Industrial Property Number
      2009-246917
    • Filing Date
      2009-10-27
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 超音波照射装置2009

    • Inventor(s)
      野々垣勝則
    • Industrial Property Rights Holder
      野々垣勝則・(有)三輪サイエンス研究所
    • Industrial Property Number
      2009-246917
    • Filing Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 薬品支援システム、および薬品決定支援プログラム2008

    • Inventor(s)
      野々垣勝則
    • Industrial Property Rights Holder
      野々垣勝則
    • Filing Date
      2008-08-29
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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