| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The suppression of SREBP-1 resulted markedly improve the hypertriglyceridemia in the mice whose LDL receptor(LDLR) disrupted and which were fed high-fat-high-calorie diet. And in mouse-peritoneal macrophages, both of SREBP-1a and -1c isoforms were expressed and suppression of both isoforms by RNA interference caused less synthesis of fatty-acids or cholesterols. Furthermore, LDLR/SREBP-1 double knockout mice showed decrement in atherosclerotic lesion formation. Those findings suggest that SREBP-1 suppression could be a therapeutic strategy for metabolic syndrome.
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