Mechanism of Insulin Sensitivity Regulation by the SUMO conjugating enzyme, Ubc9
| Project/Area Number |
20591046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
SHIBATA Hiroshi Gunma University, 生体調節研究所, 准教授 (20235584)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インスリン感受性 / 脂肪細胞 / 糖輸送 / SUMO化 / Ubc9 / GLUT4 / レトロマー複合体 / 糖輪送 / レトロマー |
|---|
| Research Abstract |
In the present study, we showed that SUMO-conjugating enzyme Ubc9 regulates the insulin sensitivity of glucose transport via GLUT4 subcellular targeting and turnover in adipocytes. In addition, we showed that the retromer complex which is involved in the endosome-to-TGN transport plays an important role in the regulation of GLUT4 turnover.
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Report
(4 results)
Research Products
(18 results)
