Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Research Abstract |
Excess nutrient intake leads to activation of mTORC1 and mTORC1 inhibits insulin signal transduction, such that activation of mTOR signaling may lead to insulin resistance and even diabetes mellitus. In the case of insulin action, mTORC1 and mTORC2 have contradictory effects on insulin signaling. Conversely, mTOR also activates Akt, a key molecule in the actions of insulin. Thus, we consider it essential to perform these studies focusing on alterations in the total LST8 amount as well as changes in mTORC1 and mTORC2 to elucidate the pathogenesis of various disorders including cancer and the metabolic syndrome.
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