Identification of a novel hepatokine that causes insulin resistance and diabetic vascular complications

• Project/Area Number: 20591054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: TAKAMURA Toshinari Kanazawa University, 医学系, 准教授 (00324111)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エネルギー / 糖質代謝異常 / インスリン抵抗性 / 2型糖尿病 / 肝臓 / ホルモン / 分泌蛋白 / 発現遺伝子解析

Research Abstract

We identified a gene encoding selenoprotein P (SeP), the hepatic expression levels of which were positively correlated with insulin resistance and hyperglycemia in patients with type 2 diabetes. SeP caused insulin resistance, at least partly, by inactivating AMPK both in vitro and in vivo.

Research Products

• [Journal Article] A liver-derived secretory protein, selenoprotein p, causes insulin resistance. (2010)
  • Author(s): Misu H, Takamura T, et al.
  • Journal Title: Cell Metab 12 Pages: 483-495
  • NAID: 120002661942
  • Peer Reviewed
• [Journal Article] Histological course of nonalcoholic fatty liver disease in Japanese patients : tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. (2010)
  • Author(s): Hamaguchi E, Takamura T, et al.
  • Journal Title: Diabetes Care 33 Pages: 284-286
  • NAID: 120001938902
  • Peer Reviewed
• [Journal Article] Altered hepatic gene expression profiles associated with myocardial ischemia. (2010)
  • Author(s): Ootsuji H, Honda M, Kaneko S, Usui S, Okajima M, Okada H, Sakai Y, Takamura T, et al.
  • Journal Title: Circ Cardiovasc Genet 3 Pages: 68-77
  • Peer Reviewed
• [Journal Article] CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes. (2010)
  • Author(s): Komura T, Sakai Y, Honda M, Takamura T, Matsushima K, Kaneko S
  • Journal Title: Diabetes 59 Pages: 634-643
  • NAID: 120002104558
  • Peer Reviewed
• [Journal Article] Aliver-derived secretory protein, selenoprotein p, causes insulin resistance. (2010)
  • Author(s): Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Honda M, Miyamoto K, Kubota T, Kubota N, KadowakiT, Kim HJ, Lee IK, Minokoshi Y, Saito Y, TakahashiK, Yamada Y, Takakura NKaneko S
  • Journal Title: Cell Metab Volume: 12 Pages: 483-495
  • Peer Reviewed
• [Journal Article] Histological course of nonalcoholic fatty liver disease in Japanese patients : tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. (2010)
  • Author(s): Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, ZenY, Takeshita Y, Kurita S, AraiK, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S
  • Journal Title: Diabetes Care Volume: 33 Pages: 284-286
  • NAID: 120001938902
  • Peer Reviewed
• [Journal Article] Altered hepatic gene expression profiles associated with myocardial ischemia. (2010)
  • Author(s): Ootsuji H, Honda M, Kaneko S, Usui S, Okajima M, Okada H, Sakai Y, Takamura T, Horimoto K, Takamura M
  • Journal Title: Circ Cardiovasc Genet Volume: 3 Pages: 68-77
  • Peer Reviewed
• [Journal Article] CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes. (2010)
  • Author(s): Komura T, Sakai Y, HondaM, Takamura T, Matsushima K, Kaneko S
  • Journal Title: Diabetes Volume: 59 Pages: 634-643
  • NAID: 120002104558
  • Peer Reviewed
• [Journal Article] Influence of age on clock gene expression in peripheral blood cells of healthy women. (2010)
  • Author(s): Ando H, Ushijima K, Kumazaki M, Takamura T, Yokota N, Saito T, Irie S, Kaneko S, Fujimura A
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 65 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. (2010)
  • Author(s): Ando H, Ushijima K, Kumazaki M, Eto T, Takamura T, Irie S, Kaneko S, Fujimura A
  • Journal Title: Chronobiol Int Volume: 27 Pages: 194-203
  • Peer Reviewed
• [Journal Article] Histological course of nonalcoholic fatty liver disease in Japanese patients : tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.:, 2010 (2010)
  • Author(s): Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, Zen Y, Takeshita Y, Kurita S, Arai K, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S
  • Journal Title: Diabetes Care 33 Pages: 284-286
  • Peer Reviewed
• [Journal Article] Influence of age on clock gene expression in peripheral blood cells of healthy women. (2010)
  • Author(s): Ando H, Ushijima K, Kumazaki M, Takamura T, Yokota N, Saito T, Irie S, Kaneko S, Fujimura A
  • Journal Title: J Gerontol A Biol Sci Med Sci 65 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. (2010)
  • Author(s): Ando H, Ushijima K, Kumazaki M, Eto T, Takamura T, Irie S, Kaneko S, Fujimura A
  • Journal Title: Chronobiol Int 27 Pages: 194-203
  • Peer Reviewed
• [Journal Article] Altered hepatic gene expression profiles associated with myocardial ischemia. (2010)
  • Author(s): Ootsuji H, Honda M, Kaneko S, Usui S, Okajima M, Okada H, Sakai Y, Takamura T, Horimoto K, Takamura M
  • Journal Title: Circ Cardiovasc Genet 3 Pages: 68-77
  • Peer Reviewed
• [Journal Article] CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes. (2010)
  • Author(s): Komura T, Sakai Y, Honda M, Takamura T, Matsushima K, Kaneko S
  • Journal Title: Diabetes 59 Pages: 634-643
  • NAID: 120002104558
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 篁俊成
  • Journal Title: 糖尿病性ケトアシドーシス・高血糖高浸透圧症候群.「栄養塾-症例で学ぶクリニカルパール」(医学書院) Pages: 232-238
• [Journal Article] Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. (2009)
  • Author(s): Nakamura S, Takamura T, et al.
  • Journal Title: J Biol Chem 284 Pages: 14809-14818
  • NAID: 120002829203
  • Peer Reviewed
• [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. (2009)
  • Author(s): Ando H, Takamura T, et al.
  • Journal Title: Biochem Biophys Res Commun 380 Pages: 684-688
  • NAID: 120001170074
  • Peer Reviewed
• [Journal Article] Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. (2009)
  • Author(s): Ando H, Ushijima K, Yanagihara H, Hayashi Y, Takamura T, et al.
  • Journal Title: Clin Exp Hypertens 31 Pages: 201-207
  • Peer Reviewed
• [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. (2009)
  • Author(s): Ando H, Takamura T, et al.
  • Journal Title: Diabetologia 52 Pages: 329-335
  • Peer Reviewed
• [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. (2009)
  • Author(s): Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Eto T, Misu H, Shiramoto M, Tsuru T, Irie S, Fujimura A, Kaneko S
  • Journal Title: Diabetologia 52 Pages: 329-335
  • Peer Reviewed
• [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. (2009)
  • Author(s): Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Nakamura S, Kumazaki M, Kurita S, Misu H, Togawa N, Fukushima T, Fujimura A, Kaneko S
  • Journal Title: Biochem Biophys Res Commun 380 Pages: 684-688
  • NAID: 120001170074
  • Peer Reviewed
• [Journal Article] Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. (2009)
  • Author(s): Ando H, Ushijima K, Yanagihara H, Hayashi Y, Takamura T, Kaneko S, Fujimura A
  • Journal Title: Clin Exp Hypertens 31 Pages: 201-207
  • Peer Reviewed
• [Journal Article] Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. (2009)
  • Author(s): Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S
  • Journal Title: J Biol Chem 284 Pages: 14809-14818
  • NAID: 120002829203
  • Peer Reviewed
• [Journal Article] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals. (2009)
  • Author(s): Sakurai M, Miura K, Takamura T, Ishizaki M, Morikawa Y, Nakamura K, Yoshita K, Kido T, Naruse Y, Kaneko S, Nakagawa H
  • Journal Title: Diabet Med 26 Pages: 753-759
  • NAID: 120001507851
  • Peer Reviewed
• [Journal Article] Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities. (2009)
  • Author(s): Sakurai M, Takamura T, Miura K, Kaneko S, Nakagawa H
  • Journal Title: Metabolism 58 Pages: 456-459
  • NAID: 120001249808
  • Peer Reviewed
• [Journal Article] Abnormal liver function tests and metabolic syndrome-is fatty liver related to risks for atherosclerosis beyond obesity? (2009)
  • Author(s): Sakurai M, Takamura T, Miura K, Kaneko S, Nakagawa H
  • Journal Title: Intern Med 48 Pages: 1573-1574
  • NAID: 130000122065
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 御簾博文, 篁俊成
  • Journal Title: 活性酸素がインスリンシグナル伝達に与える影響とその二面性.,「病態解明に迫る活性酸素シグナルと酸化ストレス-癌、神経変性疾患、循環・代謝異常にかかわるレドックス制御機構と最新の技術開発-」(谷口直之, 赤池孝章, 鈴木敬一郎, 内田浩二編)(羊土社) Pages: 212-7
• [Journal Article] (2009)
  • Author(s): 篁俊成
  • Journal Title: 内分泌・代謝系 糖尿病治療薬.ナーシングムック56「みてわかる 薬の作用メカニズム&服薬指導」(藤村昭夫編)(学研メディカル秀潤社) Pages: 126-131
• [Journal Article] (2009)
  • Author(s): 篁俊成, 金子周一
  • Journal Title: 代謝臓器としての肝臓の分子生物学.「Annual Review消化器2009」(林紀夫, 日比紀文, 上西紀夫, 下瀬川徹編)(中外医学社) Pages: 148-156
• [Journal Article] (2009)
  • Author(s): 櫻井千佳, 篁俊成
  • Journal Title: 肝疾患合併時.「糖尿病最新の治療2010-2012」(河盛隆造、岩本安彦編)(南江堂) Pages: 98-98
• [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes (2009)
  • Author(s): Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Eto T, Misu H, Shiramoto M, Tsuru T, Irie S, Fujimura A, Kaneko S
  • Journal Title: Diabetologia 52 Pages: 329-335
  • Peer Reviewed
• [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis (2009)
  • Author(s): Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Nakamura S, Kumazaki M, Kurita S, Misu H, Togawa N, Fukushima T, Fujimura A, Kaneko S
  • Journal Title: Biochem Biophys Res Commun 380 Pages: 684-688
  • NAID: 120001170074
  • Peer Reviewed
• [Journal Article] 肝臓由来分泌タンパク質 "ヘパトカイン"を標的とした2型糖尿病に対する新規治療法の開発 (2009)
  • Author(s): 御簾博文, 篁俊成
  • Journal Title: 化学工業 59 Pages: 37-42
• [Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. (2008)
  • Author(s): Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T
  • Journal Title: Hepatology 48 Pages: 109-118
  • NAID: 120001130339
  • Peer Reviewed
• [Journal Article] Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1production from hepatocytes. (2008)
  • Author(s): Takeshita Y, Takamura T, et al.
  • Journal Title: Eur J Pharmacol 579 Pages: 426-432
  • Peer Reviewed
• [Journal Article] Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients. (2008)
  • Author(s): Takamura T, et al.
  • Journal Title: Obesity (Silver Spring)
  • Peer Reviewed
• [Journal Article] BMI may be better than waist circumference for defining metabolic syndrome in Japanese women. (2008)
  • Author(s): Sakurai M, Takamura T, et al.
  • Journal Title: Diabetes Care 31 Pages: 12-12
  • Peer Reviewed
• [Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. (2008)
  • Author(s): Matsuzawa-Nagata N, Takamura T, et al.
  • Journal Title: Metabolism 57 Pages: 1071-1077
  • NAID: 120001130340
  • Peer Reviewed
• [Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. (2008)
  • Author(s): Kurita S, Takamura T, et al.
  • Journal Title: Eur J Pharmacol 588 Pages: 316-324
  • NAID: 120001130222
  • Peer Reviewed
• [Journal Article] New insulin sensitivity index from the oral glucose tolerance test. (2008)
  • Author(s): Kazama Y, Takamura T, et al.
  • Journal Title: Diabetes Res Clin Pract 79 Pages: 24-30
  • Peer Reviewed
• [Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pie iotropic effects (2008)
  • Author(s): Kurita S, Takamura T, Ota T, Matsuzawa-Nagata N, Kita Y, Uno M, Nabemoto S, Ishikura K, Misu H, Ando H, Zen Y, Nakanuma Y, Kaneko S
  • Journal Title: Eur J Pharmacol 588 Pages: 316-324
  • Peer Reviewed
• [Journal Article] Intra-thyroid blood flow in Plummer's disease (2008)
  • Author(s): Kurita S, Ando H, Kaneko S, Takamura T
  • Journal Title: Intern Med 47 Pages: 1065-1066
  • NAID: 130000078670
  • Peer Reviewed
• [Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis (2008)
  • Author(s): Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T
  • Journal Title: Hepatology 48 Pages: 109-118
  • NAID: 120001130339
  • Peer Reviewed
• [Journal Article] Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following post operative radioactive iodine-131 therapy (2008)
  • Author(s): Takeshita Y, Takamura T, Minato H, Misu H, Ando H, Yamashita T, Ikeda H, Nakanuma Y, Kaneko S
  • Journal Title: Intern Med 47 Pages: 1709-1712
  • Peer Reviewed
• [Journal Article] BMI may be better than waist circumference for definingmetabolic syndrome in Japanese women (2008)
  • Author(s): Sakurai M, Takamura T, Miura K, Kaneko S, Nakagawa H
  • Journal Title: Diabetes Care 31 Pages: 12-12
  • Peer Reviewed
• [Journal Article] SAGE application in the study of diabetes (2008)
  • Author(s): Takamura T, Misu H, Yamashi ta T, Kaneko S
  • Journal Title: Curr Pharm Biotechnol 9 Pages: 392-399
  • Peer Reviewed
• [Journal Article] Influence of physician specialty on treatment goals for diabetic patients : results of a survey given to the members of the Ishikawa medical association (2008)
  • Author(s): Koizumi J, Matsukura T, Oyama O, Maeda T, Nomura H, Asano A, Kitatani M, Takamura T, Kondou K
  • Journal Title: General Medicine 9 Pages: 71-79
  • NAID: 10029403685
  • Peer Reviewed
• [Journal Article] ケースバイケースで適したインスリン導入法を考える (2008)
  • Author(s): 岩本安彦, 番度行弘, 小林正, 浦風雅春, 古家大祐, 篁俊成
  • Journal Title: Pharma Medica 25 Pages: 113-115
• [Journal Article] Obesity Upregulates Genes Involved in Oxidative Phospho rylation in Livers of Diabetic Patients (2008)
  • Author(s): Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S
  • Journal Title: Obesity (Silver Spring) 16 Pages: 2601-2609
  • Peer Reviewed
• [Journal Article] 肥満患者にインスリン療法を導入すべきか? (2008)
  • Author(s): 加藤健一郎, 安藤仁, 清水暁子, 篁俊成
  • Journal Title: Progress in Medicine 28 Pages: 349-352
• [Journal Article] 新時代の糖尿病学(2)-病因・診断・治療研究の進歩- (2008)
  • Author(s): 篁俊成
  • Journal Title: 日本臨床 66 Pages: 33-37
• [Journal Article] 脂肪肝とリポトキシシティ (2008)
  • Author(s): 太田嗣人, 篁俊成
  • Journal Title: The Lipid 19 Pages: 20-26
• [Journal Article] スルホニル尿素薬とαグルコシダーゼ阻害薬 (2008)
  • Author(s): 御簾博文, 篁俊成
  • Journal Title: 日本臨床 66 Pages: 305-310
• [Journal Article] 肝臓のトランスクリプトームからみた糖尿病 (2008)
  • Author(s): 篁俊成, 安藤仁, 御簾博文, 金子周一
  • Journal Title: 糖尿病合併症 22 Pages: 136-140
• [Journal Article] 糖質代謝異常 (2008)
  • Author(s): 篁俊成
  • Journal Title: 日本臨床 66 Pages: 33-37
• [Journal Article] 1型糖尿病とバセドウ病を同時期に診断しえた多腺性自己免疫症候群の2例 (2008)
  • Author(s): 乙田敏城, 櫻井勝, 太田嗣人, 栗田征一郎, 御簾博文, 清水暁子, 安藤仁, 金子周一, 篁俊成
  • Journal Title: 日本糖尿病学会 51 Pages: 323-327
  • NAID: 10021275076
  • Peer Reviewed
• [Presentation] スローエイジングを目指す2型糖尿病の全人的ケア. (2011)
  • Author(s): 篁俊成
  • Organizer: 第52回北陸支部生涯教育講演会
  • Place of Presentation: 金沢大学附属病院宝ホール、金沢市、石川
  • Year and Date: 2011-03-13
• [Presentation] スローエイジングを目指す2型糖尿病の全人的ケア (2011)
  • Author(s): 篁俊成
  • Organizer: 第52回北陸支部生涯教育講演会
  • Place of Presentation: 金沢大学十全講堂、金沢市、石川(招待講演)
  • Year and Date: 2011-03-13
• [Presentation] スローエイジングを見据えた糖尿病の総合的治療戦略 (2011)
  • Author(s): 篁俊成
  • Organizer: 第50回日本臨床検査医学会東海・北陸支部総会、第322回日本臨床化学会、東海・北陸支部例会連合大会 シンポジウム
  • Place of Presentation: 金沢大学附属病院宝ホール、金沢市、石川(招待講演)
  • Year and Date: 2011-03-13
• [Presentation] 過栄養状態の肝臓が形成する2型糖尿病の病態. (2011)
  • Author(s): 篁俊成
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡
  • Year and Date: 2011-02-18
• [Presentation] 過栄養状態の肝臓が形成する2型糖尿病の病態 (2011)
  • Author(s): 篁俊成
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡国際会議場、福岡市、福岡(招待講演)
  • Year and Date: 2011-02-18
• [Presentation] (2011)
  • Author(s): Misu H, Ishikura K, Takayama H, Hayashi H, Ota T, Kaneko S, Takamura T
  • Organizer: Keystone Symposia - Obesity
  • Place of Presentation: Keystone Resort, Keystone, Colorado, USA
  • Year and Date: 2011-01-16
• [Presentation] Anovel hepatokine selenoprotein P causes insulin resistance by suppressing AMPK (2011)
  • Author(s): Hirofumi Misu, Kazuhide Ishikura, Hiroaki Takayama, Hiroto Hayashi, Tsuguhito Ota, Shuichi Kaneko, Toshinari Takamura
  • Organizer: Keystone Symposia-Obesity
  • Place of Presentation: Keystone Resort, Keystone, Colorado, USA
  • Year and Date: 2011-01-16
• [Presentation] Proteasome dysfunction in obesity contributes to ER stress, enhanced autophagy and insulin resistance in type 2 diabetic liver. (2011)
  • Author(s): 篁俊成, et al.
  • Organizer: Keystone Symposia - Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  • Place of Presentation: Keystone Resort, Keystone, Colorado, USA
  • Year and Date: 2011-01-15
• [Presentation] Proteasome dysfunction in obesity contributes to ER stress, enhanced autophagy and insulin resistance in type 2 diabetic liver (2011)
  • Author(s): Toshinari Takamura, Toshiki Otoda, Hirofumi Misu, Tsuguhito Ota, Shuichi Kaneko
  • Organizer: Keystone Symposia-Obesity
  • Place of Presentation: Keystone Resort, Keystone, Colorado, USA
  • Year and Date: 2011-01-15
• [Presentation] Nutrition and fitness for prevention / treatment of NAFLD / NASH. (2010)
  • Author(s): 篁俊成, 金子周一
  • Organizer: The 9th Single Topic Conference NASH 2010
  • Place of Presentation: グランドプリンスホテル高輪、品川、東京
  • Year and Date: 2010-11-19
• [Presentation] Nutrition and fitness for prevention/treatment of NAFLD/NASH (2010)
  • Author(s): Toshinari Takamura, Shuichi Kaneko
  • Organizer: The 9th Single Topic Conference NASH 2010
  • Place of Presentation: グランドプリンスホテル高輪、品川、東京(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] スローエイジング糖尿病ケアにおけるインスリン療法のあり方. (2010)
  • Author(s): 篁俊成
  • Organizer: 第25回日本糖尿病合併症学会総会ランチョンセミナー
  • Place of Presentation: びわ湖ホール、大津市、滋賀
  • Year and Date: 2010-10-23
• [Presentation] スローエイジング糖尿病ケアにおけるインスリン療法のあり方 (2010)
  • Author(s): 篁俊成
  • Organizer: 第25回日本糖尿病合併症学会総会 ランチョンセミナー
  • Place of Presentation: びわ湖ホール、大津市、滋賀(招待講演)
  • Year and Date: 2010-10-23
• [Presentation] CCR5 Promotes Adipose Tissue Inflammation and Whole-Body Insulin Resistance. (2010)
  • Author(s): Ota T, Kitade H, Sawamoto K, Inoue H, Takamura T, et al.
  • Organizer: 8th International Diabetes Federation Western Pacific Region Congress
  • Place of Presentation: BEXCO, Busan, Korea(一般演題(ポスター))
  • Year and Date: 2010-10-19
• [Presentation] CCR5 Promotes Adipose Tissue Inflammation and Whole-Body Insulin Resistance (2010)
  • Author(s): Ota T, Kitade H, Sawamoto K, Inoue H, Takamura T, MiyamotoK, Mukaida N, Kaneko S
  • Organizer: 8th International Diabetes Federation Western Pacific Region Congress
  • Place of Presentation: BEXCO, Busan, Korea(一般演題(ポスター))
  • Year and Date: 2010-10-19
• [Presentation] Liver-derived hormone selenoprotein P is a novel suppressor of AMPK that induces insulin resistance (2010)
  • Author(s): Hirofumi Misu, Toshinari Taka mura, Hiroaki Takayama, HirotoHayashi, Tetsuya Kubota, NaotoKubota, Takashi Kadowaki, Yasuhiko Minokoshi, Shuichi Kaneko
  • Organizer: FASEB SUMMER RESEARCH CONFERENCES
  • Place of Presentation: 大津プリンスホテル、大津市、滋賀(一般演題(ポスター))
  • Year and Date: 2010-10-08
• [Presentation] アンチエイジングを見据えた2型糖尿病の総合的治療戦略. (2010)
  • Author(s): 篁俊成
  • Organizer: BioJapan 2010講演
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川
  • Year and Date: 2010-09-30
• [Presentation] アンチエイジングを見据えた2型糖尿病の総合的治療戦略 (2010)
  • Author(s): 篁俊成
  • Organizer: Bio Japan 2010
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川(招待講演)
  • Year and Date: 2010-09-30
• [Presentation] Proteasome dysfunction contributes to endoplasmic reticulum stress and insulin resistance in type 2 diabetic liver. (2010)
  • Author(s): Otoda T , Misu H, Kurita S, Yamamoto M, Ota T, Shima K, Iseki S, Murata S, Tanaka K, Kaneko S, Takamura T
  • Organizer: 第46回欧州糖尿病学会議(EASD),(一般演題(ポスター))
  • Place of Presentation: "Massan" conference and exhibition centre, Stockholm, Sweden
  • Year and Date: 2010-09-23
• [Presentation] Proteasome dysfunction contributes to endoplasmic reticulum stress and insulin resistance in type 2 diabetic liver (2010)
  • Author(s): Toshiki Otoda, Hirofumi Misu, Seiichiro Kurita, Miyuki Yamamoto, Tsuguhito Ota, Kosuke R.Shima, Shoichi Iseki, Shigeo.Murata, Keiji Tanaka, Shuichi Kaneko, Toshinari Takamura
  • Organizer: 第46回欧州糖尿病学会議(EASD)
  • Place of Presentation: Massanconference andexhibition centre, Stockholm, Sweden(一般演題(ポスター))
  • Year and Date: 2010-09-23
• [Presentation] Molecular pathology underlying insulin resistance in type 2 diabetic liver. (2010)
  • Author(s): 篁俊成
  • Organizer: Symposium at Kangwon National University "Integrative approaches in the battle against diabetes"
  • Place of Presentation: Kangwon National University, Chuncheon, Korea(招待講演)
  • Year and Date: 2010-09-09
• [Presentation] Molecular pathology underlying insulin resistance in type 2 diabetic liver (2010)
  • Author(s): Takamura T
  • Organizer: Symposium at Kangwon National University "lntegrative approaches in the battle against diabetes"
  • Place of Presentation: Kangwon National University, Chuncheon, Korea(招待講演)
  • Year and Date: 2010-09-09
• [Presentation] CCR5 Ablation Prevents Insulin Resistance Induced by High-Fat Feedingor Leptin Deficiency (2010)
  • Author(s): Ota T, Kitade H, Sawamoto K, Inoue H, Takamura T, Miyamoto K, Mukaida N, Kaneko S
  • Organizer: American Diabetes Association 70th Scientific Sessions
  • Place of Presentation: Orange County ConventionCenter, Orlando, Florida, USA(一般演題(口演))
  • Year and Date: 2010-06-30
• [Presentation] Hepatic overproduction of selenoprotein P induces insulin resistance and hyperglycemia in type 2 diabetes (2010)
  • Author(s): Misu H, Takamura T, Saito Y, Takahashi K, Kaneko S
  • Organizer: 9^<th> International Symposium on Selenium in Biology and Medicine
  • Place of Presentation: 京都大学百周年時計台記念館, 京都市、京都(一般演題(口演))
  • Year and Date: 2010-06-03
• [Presentation] Molecular pathology underlying insulin resistance in type 2 diabetic liver. (2010)
  • Author(s): 篁俊成, 御簾博文, 金子周一
  • Organizer: 第53回日本糖尿病学会年次学術集会シンポジウム
  • Place of Presentation: ホテルグランヴィア岡山、岡山市、岡山
  • Year and Date: 2010-05-29
• [Presentation] Molecular pathology underlying insulin resistance in type 2 diabetic liver (2010)
  • Author(s): 篁俊成, 御簾博文, 金子周一
  • Organizer: 第53回日本糖尿病学会年次学術集会シンポジウム
  • Place of Presentation: ホテルグランヴィア岡山、岡山市、岡山
  • Year and Date: 2010-05-29
• [Presentation] 肝脂肪化と炎症・インスリン抵抗性をつなぐ分子メカニズム-パルミチン酸処置H4IIEC肝細胞モデルを用いた検討 (2010)
  • Author(s): 御簾博文, 篁俊威, 金子周一
  • Organizer: 第96回日本消化器病学会、ワークショップ
  • Place of Presentation: 新潟県民会館、新潟市、新潟
  • Year and Date: 2010-04-22
• [Presentation] Glycemic control predicts for liver fibrosis progression in Japanese patients with NAFLD who underwent consecutive liver biopsies (2010)
  • Author(s): Takeshita Y, Takamura T, Hamaguchi E, Zen Y, Misu H, Arai K, Yamashita T, Mizukoshi E, Sasaki M, Nakahama Y, Kaneko S
  • Organizer: 45th Annual Meeting of the European Associationfor the Study of the Liver
  • Place of Presentation: Reed Messe Wien Exhibition & Congress Center, Austria, Vienna
  • Year and Date: 2010-04-15
• [Presentation] Selenoprotein P : A liver-derived hormone regulating systemic insulin sensitivity. (2010)
  • Author(s): Misu H, Takayama H, Kaneko H, Takamura T
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 国立京都国際会館、(京都)
  • Year and Date: 2010-03-30
• [Presentation] Dose-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes (2010)
  • Author(s): Iwakami S, Misu H, Sugimori M, Matsugo S, Kaneko S, Takamura T
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 国立京都国際会館、(京都)
  • Year and Date: 2010-03-30
• [Presentation] 糖尿病臨床医として脂肪肝をどう捉えるか (2010)
  • Author(s): 篁俊成
  • Organizer: 第44回糖尿病学の進歩教育講演
  • Place of Presentation: 大阪国際会議場、大阪市、大阪
  • Year and Date: 2010-03-06
• [Presentation] 糖尿病臨床医として脂肪肝をどう捉えるか? (2010)
  • Author(s): 篁俊成
  • Organizer: 第44回糖尿病学の進歩
  • Place of Presentation: 大阪国際会議場、(大阪)
  • Year and Date: 2010-03-06
• [Presentation] 肥満に関連したプロテアソーム機能障害は肝臓での小胞体ストレスとインスリン抵抗性を誘導する (2009)
  • Author(s): 乙田敏城, 御簾博文, 栗田征一郎, 山本美由紀, 太田嗣人, 井関尚一, 村田茂穂, 田中啓二, 金子周一, 篁俊成
  • Organizer: 第21回分子糖尿病学シンポジウム、シンポジウム
  • Place of Presentation: 和歌山県立医科大学講堂(和歌山)
  • Year and Date: 2009-12-12
• [Presentation] 2型糖尿病患者における酸化的リン酸化遺伝子群発現異常の意義 (2009)
  • Author(s): 篁俊成, 御簾博文, 金子周一
  • Organizer: 第32回日本分子生物学会、ワークショップ
  • Place of Presentation: パシフィコ横浜、(横浜)
  • Year and Date: 2009-12-12
• [Presentation] アンチエイジングを見据えた2型糖尿病の総合的治療戦略. (2009)
  • Author(s): 篁俊成
  • Organizer: 第30回日本臨床薬理学会年会、ランチョンセミナー
  • Place of Presentation: パシフィコ横浜、(横浜)
  • Year and Date: 2009-12-05
• [Presentation] Clinical and molecular pathology of type 2 diabetic liver. (2009)
  • Author(s): 篁俊成, et al.
  • Organizer: The 15th Korea-Japan Symposium on Diabetes Mellitus, シンポジウム
  • Place of Presentation: International Convention Center, Jeju, Jeju island, Korea
  • Year and Date: 2009-11-20
• [Presentation] Adipose tissue derived mesenchymal stem cells are capable to modulate liver inflammation in mouse of non-alcoholic steatohepatitis. (2009)
  • Author(s): Seki A, Sakai Y, Tatsumi I, Komura T, Fujinaga H, Honda M, Takamura T, Ochiya T, Kaneko S
  • Organizer: 60th American Association for the Study of Liver Diseases, Annual Meeting
  • Place of Presentation: John B. Hynes Convention Center, Boston, (USA)
  • Year and Date: 2009-11-03
• [Presentation] How to motivate your team?医療チームを盛り上げ、磨き上げる臨床研究 (2009)
  • Author(s): 篁俊成
  • Organizer: 第9回CRCと臨床試験のあり方を考える会議、シンポジウム
  • Place of Presentation: パシフィコ横浜、(横浜)
  • Year and Date: 2009-09-13
• [Presentation] NAFLD-消化器病学と糖尿病学の接点 (2009)
  • Author(s): 篁俊成
  • Organizer: 第19回西日本臨床胆汁酸研究会
  • Place of Presentation: リーガロイヤルホテル大阪、(大阪)
  • Year and Date: 2009-07-25
• [Presentation] 糖尿病学と肝臓病学の接点としての非アルコール性脂肪性肝疾患. (2009)
  • Author(s): 篁俊成
  • Organizer: 第52回日本糖尿病学会年次学術集会教育講演
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪、大阪市、大阪
  • Year and Date: 2009-05-24
• [Presentation] 糖尿病学と肝臓病学の接点としての非アルコール性脂肪性肝疾患 (2009)
  • Author(s): 篁俊成
  • Organizer: 第52回日本糖尿病学会年次学術集会,教育講演
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル大阪、(大阪)
  • Year and Date: 2009-05-24
• [Presentation] 2型糖尿病患者の病態と酸化的リン酸化遺伝子群の協調的発現異常. (2009)
  • Author(s): 篁俊成, 御簾博文, 金子周一
  • Organizer: 第52回日本糖尿病学会年次学術集会シンポジウム
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪、大阪市、大阪
  • Year and Date: 2009-05-22
• [Presentation] 2型糖尿病患者の病態と酸化的リン酸化遺伝子群の協調的発現異常 (2009)
  • Author(s): 篁俊成, 御簾博文, 金子周一
  • Organizer: 第52回日本糖尿病学会年次学術集会,シンポジウム
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル大阪、(大阪)
  • Year and Date: 2009-05-22
• [Presentation] 副腎不全、Cushing徴候、BigIGF2誘発性低血糖を来した副腎癌剖検例 (2009)
  • Author(s): 石倉和秀, 田治孔明, 竹下有美枝, 上山奈央美, 濱口えりか, 御簾博文, 笠原寿郎, 鈴木潮人, 大井章史, 押野谷幸之輔, 今泉範子, 中川淳, 金子周一, 篁俊成
  • Organizer: 第19回臨床内分泌代謝Up date
  • Place of Presentation: 東京
  • Year and Date: 2009-03-14
• [Presentation] IgG関連疾患の経過中に出現したリンパ球性下垂体炎の男性例 (2009)
  • Author(s): 田治孔明, 赤堀弘, 原田ゆかり, 毛利研祐, 石倉和秀, 竹下有美枝, 御簾博文, 川野充弘, 篁俊成, 林康彦, 林裕, 潰田潤一郎
  • Organizer: 第19回臨床内分泌代謝Up date
  • Place of Presentation: 東京
  • Year and Date: 2009-03-13
• [Presentation] Identification of a redox-associated hepatokine that contributes to systemic insulin resistance. (2009)
  • Author(s): 篁俊成, et al.
  • Organizer: Keystone Symposia on Molecular and Cellular Biology 2009 - Type 2 diabtes and insulin resistance
  • Place of Presentation: Fairmont Banff Springs, Banff, Alberta, Canada(一般演題(ポスター))
  • Year and Date: 2009-01-23
• [Presentation] Clinical and molecular pathology of type 2 diabetic liver. (2009)
  • Author(s): Takamura T, Hirofumi Misu, Shuichi Kaneko
  • Organizer: The 15th Korea-Japan Symposium on Diabetes Mellitus
  • Place of Presentation: International Convention Center Jeju, Jeju, (Korea)
• [Presentation] 肝臓でのセノプロテインP過剰産生は2型糖尿病患者のインスリン抵抗性の原因となる (2009)
  • Author(s): 御簾博文, 篁俊成
  • Organizer: 第62回日本酸化ストレス学会、シンポジウム
  • Place of Presentation: 九州大学医学部百年講堂、(福岡)
• [Presentation] 臓器特異的インスリン抵抗性が非アルコール性脂肪性肝疾患(NAFLD)患者の肝病理診断にもたらす意義 (2009)
  • Author(s): 加藤健一郎, 篁俊成, 金子周一
  • Organizer: 第13回日本肝臓学会大会、シンポジウム
  • Place of Presentation: 国立京都国際会館、(京都)
• [Presentation] 新規インスリン抵抗性誘導ヘパトカインセレノプロテインP同定-セレン含有タンパクによる糖代謝悪化の可能性 (2009)
  • Author(s): 御簾博文, 高山浩昭, 林寛人, 篁俊成
  • Organizer: 第82回日本生化学学会、シンポジウム
  • Place of Presentation: 神戸ポートアイランド、(神戸)
• [Presentation] 臓器特異的インスリン抵抗性が非アルコール性脂肪性肝疾患(NAFLD)患者の肝病理診断にもたらす意義 (2009)
  • Author(s): 加藤健一郎, 篁俊成, 竹下有美枝, 横山将嘉, 濱口えりか, 齋藤麗奈, 堀口美輝, 御簾博文, 太田嗣人, 金子周一
  • Organizer: 第24回日本糖尿病合併症学会、ワークショップ
  • Place of Presentation: 岡山コンベンションセンター(岡山)
• [Presentation] 肝臓由来分泌タンパクセレノプロティンPは2型糖尿病におけるインスリン抵抗性の原因となる (2008)
  • Author(s): 御簾博文, 篁俊成, 金子周一
  • Organizer: 第20回分子糖尿病学シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-13
• [Presentation] 過栄養が形成する肝臓の病理と病態 (2008)
  • Author(s): 篁俊成
  • Organizer: 第13回静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
  • Year and Date: 2008-11-08
• [Presentation] 「NASHへの挑戦」一創薬の可能性を探る-、肝脂肪化と炎症のリンクーToxic Lipidは何か? (2008)
  • Author(s): 篁俊成
  • Organizer: 第32回ヒューマンサイエンス総合研究セミナー
  • Place of Presentation: 東京
  • Year and Date: 2008-10-07
• [Presentation] 肝細胞インスリン感受性に及ぼすパルミチン酸とオレイン酸の相互作用 (2008)
  • Author(s): 高山浩昭, 長田直人, 中村誠二, 御簾博文, 太田嗣人, 井上啓, 金子周一, 篁俊成
  • Organizer: 第23回日本糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-04
• [Presentation] インスリン抵抗性で生じる小胞体ストレスはapoB分泌を選択的に阻害し、脂肪肝を促進する (2008)
  • Author(s): 太田嗣人, 篁俊成, 金子周一, Henry G
  • Organizer: 第23回日本糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-04
• [Presentation] Different fatty acids inhibit apoB100 secretion by both common and unique molecular pathways (2008)
  • Author(s): Ota T, Gayet C, Ginsberg H
  • Organizer: 第44回欧州糖尿病学会議(EASD)
  • Place of Presentation: Rome
  • Year and Date: 2008-09-10
• [Presentation] Role of mitochondria-derived reactive oxygen species in fat-induced insulin resistance in liver. (2008)
  • Author(s): 篁俊成, et al.
  • Organizer: 44th Annual meeting of European Association for the Study of Diabetes (EASD)
  • Place of Presentation: Nuova Fiera di Roma conference and exhibition centre, Rome, Italy(一般演題(ポスター))
  • Year and Date: 2008-09-08
• [Presentation] Role of mitochondria-derived reactive oxygen species in fat-induced insulin resi stance in liver (2008)
  • Author(s): Takamura T, Nagata N, Nakamura S, Takayama H, Sugimori M, Misu H, Kaneko S
  • Organizer: 第44回欧州糖尿病学会議(EASD)
  • Place of Presentation: Rome
  • Year and Date: 2008-09-08
• [Presentation] IgG4関連疾患の経過中に出現したリンパ球性下垂体炎の1男性例 (2008)
  • Author(s): 田治孔明, 赤堀弘, 原田ゆかり, 毛利研祐, 石倉和秀, 竹下有美枝, 御簾博文, 篁俊成, 岩戸雅之, 林康彦, 林裕, 潰田潤一郎
  • Organizer: 第14回北陸間脳下垂体腫瘍研究会プログラム
  • Place of Presentation: 金沢
  • Year and Date: 2008-09-06
• [Presentation] Molecular mechanisms underlying fat-induced insulin resistance in the liver (2008)
  • Author(s): Toshinari Takamura
  • Organizer: The 17th Korean Diabetes Association Summer Workshop & 2008 Symposium
  • Place of Presentation: Grand Hilton Seoul Hotel, Seoul, Korea(招待講演)
  • Year and Date: 2008-08-23
• [Presentation] Molecular Mechanisms Underlying Fat-induced insulin resistance in the liver (2008)
  • Author(s): Takamura T
  • Organizer: 第17回 Korea Diabetes Association Summer Workshop&2008 Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2008-08-23
• [Presentation] 細胞内活性酸素がインスリンシグナル伝達に及ぼす影響とその二面性 (2008)
  • Author(s): 御簾博文
  • Organizer: 第19回レドックス生命科学第170委員会
  • Place of Presentation: 御殿場
  • Year and Date: 2008-07-31
• [Presentation] 抗アレルギー薬トラニラストはラツトNASHモデルのマクロファージ活性化と肝病理進展を阻止する (2008)
  • Author(s): 栗田征一郎, 篁俊成, 宇野将文, 太田嗣人, 長田直人, 喜多裕樹, 御簾博文, 安藤仁, 全陽, 中沼安二, 金子周一
  • Organizer: 第44回日本肝臓学会
  • Place of Presentation: 松山
  • Year and Date: 2008-06-05
• [Presentation] 末梢分子時計障害と関連する代謝異常の分析 (2008)
  • Author(s): 島孝佑, 安藤仁, 篁俊成, 長田直人, 藤村昭夫, 金子周一
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 2型糖尿病患者における食後インスジン動態、高血糖、脂質異常におよぼすインスリンアスパルトの効果 (2008)
  • Author(s): 清水暁子, 安藤仁, 栗田征一郎, 永野倫子, 長田美津子, 加藤健一郎, 石倉和秀, 田治孔明, 宇野将文, 御簾博文, 吉田知孝, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 健常者および1型、2型糖尿病患者間で異なるグルカゴン分泌制御機構 (2008)
  • Author(s): 上山奈央美, 安藤仁, 櫻井勝, 清水暁子, 加藤健一郎, 栗田征一郎, 御簾博文, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 糖尿病新規発症に及ぼす喫煙と腹部肥満との交互作用 (2008)
  • Author(s): 櫻井勝, 三浦克之, 篁俊成, 石崎昌夫, 森河裕子, 城戸照彦, 成瀬優知, 金子周一, 中川秀昭
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 主観的包括的評価(SGA)は糖尿病入院患者の把握に有用か? (2008)
  • Author(s): 河野貴子, 黒川千佳, 八幡陽子, 田島奈津美, 黒川素江, 西野喜美子, 関軒裕佳, 竹森千尋, 山下千鶴子, 内潟将宏, 田治孔明, 石倉和秀, 栗田征一郎, 御簾博文, 安藤仁, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 非定型抗精神病薬服用患者における耐糖能フォローアップの実態 (2008)
  • Author(s): 田平裕美子, 安藤仁, 増江優子, 土山奈央美, 石倉和秀, 田治孔明
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 抗アレルギー薬トラニラストはマクロファージの活性化とインスリン抵抗性を改善する (2008)
  • Author(s): 栗田征一郎, 宇野将文, 御簾博文, 安藤仁, 太田嗣人, 長田直人, 喜多裕樹, 乙田敏城, 全陽, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 末梢血単核球の遺伝子発現プロファイルが糖尿病血管合併症の存在を映し出す可能性 (2008)
  • Author(s): 篁俊成, 中村誠二, 内潟将宏, 清水暁子, 竹下有美枝, 栗田征一郎, 御簾博文, 安藤仁, 松原謙一, 金子周一
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 2型糖尿病患者における末梢血白血球の時計遺伝子発現リズム (2008)
  • Author(s): 安藤仁, 篁俊成, 長田直人, 島孝佑, 藤村昭夫, 金子周一
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 非アルコール性脂肪肝患者における肝病理像と臓器別インスリン抵抗性 (2008)
  • Author(s): 加藤健一郎, 櫻井勝, 横山将嘉, 清水暁子, 栗田征一郎, 御簾博文, 安藤仁, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 血清ALT値と脂肪肝は筋でのインスリン抵抗性の指標となり得る (2008)
  • Author(s): 横山将嘉, 篁俊成, 藤岡正彦, 村本信吾
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 糖尿病治療チームの指導ノウハウを用いた生活習慣病発症予防システムの構築 (2008)
  • Author(s): 内潟将宏, 山村奈津絵, 竹森千尋, 関軒裕佳, 黒川素江, 河野貴子, 田島奈津美, 八幡陽子, 黒川千佳, 田平裕美子, 東敬一郎, 吉谷久子, 長田美津子, 米田由美, 田治孔明, 石倉和秀, 栗田征一郎, 御簾博文, 安藤仁, 金子周一, 安藤仁, 金子周一, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 新規肝臓由来分泌タンパクトHepatokineβ血中濃度は2型糖尿病患者においてHbAlcと相関する (2008)
  • Author(s): 石倉和秀, 御簾博文, 篁俊成, 長田直人, 清水暁子, 栗田征一郎, 竹下有美枝, 濱口えりか, 安藤仁, 金子周一
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] メトホルミンが非アルコール性脂肪肝炎モデルの肝病理を改善した分子背景 (2008)
  • Author(s): 喜多裕樹, 栗田征一郎, 宇野将文, 長田直人, 太田嗣人, 安藤仁, 篁俊成
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Book] 糖尿病・肥満患者における遺伝子発現変化(Annual Review糖尿病・代謝・内分泌)(寺内康夫、伊藤裕、石橋俊(編)) (2011)
  • Author(s): 篁俊成
  • Publisher: 中外医学社 東京
• [Book] 糖尿病・肥満患者における遺伝子発現変化、Annual Renew 2011糖尿病・代謝・内分泌 (2011)
  • Author(s): 篁俊成
  • Publisher: 中外医学社
• [Book] 2型糖尿病治療のめざすところ、糖尿病チーム医療の教科書 (2010)
  • Author(s): 篁俊成
  • Publisher: メジカルビュー社
• [Book] 今すぐ始めるチーム医療、糖尿病チーム医療の教科書 (2010)
  • Author(s): 篁俊成
  • Publisher: メジカルビュー社
• [Book] 糖尿病性ケトアシドーシス・高血糖高浸透圧症候群.「栄養塾一症例で学ぶクリニカルパール」 (2010)
  • Author(s): 篁俊成
  • Publisher: 医学書院
• [Book] Annual Review 2009消化器(代謝臓器としての肝臓の分子生物学)(林紀夫,日比紀文,上西紀夫,下瀬川徹) (2009)
  • Author(s): 篁俊成, 金子周一
  • Publisher: 中外医学社 東京
• [Book] 病態解明に迫る活性酸素シグナルと酸化ストレス-癌、神経変性疾患、循環・代謝異常にかかわるレドックス制御機構と最新の技術開発-(活性酸素がインスリンシグナル伝達に与える影響とその二面性)(谷口直之,赤池孝章,鈴木敬一郎,内田浩二(編)) (2009)
  • Author(s): 御簾博文, 篁俊成
  • Publisher: 羊土社 東京
• [Book] 新時代の糖尿病学-病因・診断・治療研究の進歩-(糖質代謝異常) (2008)
  • Author(s): 篁俊成
  • Publisher: 日本臨床 大阪
• [Remarks] ホームページ等
• [Remarks] 研究室Web site
  • URL: http://teamichiken.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 研究室Facebook Fan Page
  • URL: https://www.facebook.com/TakamuraLab
• [Remarks] NPO法人Team DiET(チームダイエット)
  • URL: http://www.teamdiet.jp/
• [Remarks] Team DiET Facebook Fan Page
  • URL: http://www.facebook.com/pages/Team-DiET/157807097607098
• [Remarks] 金沢大学医学部附属病院(旧第一内科)恒常性制御学講座
  • URL: http://www.m-kanazawa.jp/index.html
• [Remarks] 研究室Web site
  • URL: http://teamichiken.w3.kanazawa-u.ac.ip/index.html
• [Remarks]
• [Remarks] 35金沢大学医学部附属病院(旧第一内科)恒常性制御学講座
  • URL: http://www.m-kanazawa.in/index.html
• [Remarks] NPO法人 Team DiET
  • URL: http://www.teamdiet.ip/
• [Remarks]
  • URL: http://www.facebook.com/naees/Team-DiET/157807097607098
• [Patent(Industrial Property Rights)] 糖尿病関連肝臓由来分泌タンパク質の2型糖尿病または血管障害の診断または治療への利用 (2008)
  • Inventor(s): 篁俊成、金子周一、御簾博文、高倉伸幸
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2008-12-15
• [Patent(Industrial Property Rights)] 新規な肝疾患の予防または治療ならびにインスリン抵抗性改善剤 (2008)
  • Inventor(s): 篁 俊成、金子周一、安藤仁、太田嗣人、御簾博文、栗田征一郎, 宇野将文
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2008-10-24
• [Patent(Industrial Property Rights)] 新規な肝疾患の予防または治療ならびにインスリン抵抗性改善剤 (2008)
  • Inventor(s): 篁俊成, 金子周一, 安藤仁, 太田嗣人, 御簾博文, 栗田征一郎, 宇野将文金
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2008-274758
  • Filing Date: 2008-10-24