The roles of TCF7L2 gene in the development of pancreas and pathogenesis of diabetes

• Project/Area Number: 20591055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Yamanashi
• Principal Investigator: AIDA Kaoru University of Yamanashi, 医学部附属病院, 講師 (50184015)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Tetsuro 山梨大学, 医学工学総合研究部, 教授 (30113442)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 糖尿病 / 膵発生 / 再生医療 / TCF7L2遺伝子 / β-catenin / [○!R]-catenin

Research Abstract

Wng signaling cascade has a crucial role in development of many tissues. The TCF7L2 gene product is a transcription factor involved in the cascase, and is reported to be related to the pathogenesis of type 2 diabetes. We have costruct a pancreas-specific knock-out mouse of β-catenin, an upstream gene of TCF7L2. Unexpectedly, those mice had normal glucose tolerance and normal pancreatic architecture. We are analyzing active TCF7L2-overexpressing mice.

Research Products

• [Journal Article] RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates b-cell death in fulminant type 1 diabetes. (2011)
  • Author(s): Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, Tetsuro Kobayashi
  • Journal Title: Diabetes 60 Pages: 884-884
  • Peer Reviewed
• [Journal Article] RIG-I-and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes. (2011)
  • Author(s): Aida K.
  • Journal Title: Diabetes Volume: 60 Pages: 884-889
  • Peer Reviewed
• [Journal Article] 「II感染症と1型糖尿病劇症1 型糖尿病とウィルス感染」、劇症1型糖尿病とウイルス感染 (2010)
  • Author(s): 會田薫, 西田頼子, 田中昌一郎, 丸山太郎, 島田朗, 小林哲郎
  • Journal Title: Diabetes Frontier 21 Pages: 307-313
• [Journal Article] 緩徐進行1型糖尿病(SPIDDM)および2型糖尿病患者におけるCXCL10とインスリン抵抗性に関する検討 (2010)
  • Author(s): 會田薫, 小林哲郎
  • Journal Title: Therapeutic Research 31(6) Pages: 45-49
• [Journal Article] 劇症1型糖尿病とウィルス感染 (2010)
  • Author(s): 會田薫
  • Journal Title: Diabetes Frontier Volume: 21 Pages: 543-551
• [Journal Article] 緩徐進行1型糖尿病(SPIDDM)および2型糖尿病患者におけるCXCL10とインスリン抵抗性に関する検討 (2010)
  • Author(s): 會田薫
  • Journal Title: Therapeutic Research Volume: 31 Pages: 45-49
• [Journal Article] 山梨地域糖尿病療養指導士の歩み (2009)
  • Author(s): 會田薫, 小林哲郎
  • Journal Title: 肥満と糖尿病5・6 Vol.8 No.3 Pages: 437-439
• [Journal Article] Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit -A Mechanism of Accelerated Beta-Cell Failure in Fulminant Type 1 Diabetes-. (2009)
  • Author(s): Shoichiro Tanaka, Yoriko Nishida, Kaoru Aida, Taro maruyama, Akira Shimada, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Takahashi, Daiichiro Akiyama, Sayaka Arai-Yamashita, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Ryohei Katoh, Toyoshi Endo, Tetsuro Kobayashi
  • Journal Title: Diabetes 58 Pages: 2285-2291
  • Peer Reviewed
• [Journal Article] Diabetes associated with autoimmune pancreatitis : new insights into the mechanism of beta-cell dysfunction. (2009)
  • Author(s): Tetsuro Kobayashi, Shoichiro Tanaka, Kaoru Aida,, Soichi Takizawa, Hiroki Shimura, Toyoshi Endo.
  • Journal Title: Expert Review of Endocrinology & Metabolism. 4 Pages: 591-602
  • Peer Reviewed
• [Journal Article] 緩徐進行1型糖尿病(SPIDDM)の最近の知見 (2009)
  • Author(s): 小林哲郎, 田中昌一郎, 会田薫
  • Journal Title: 糖尿病 第52 巻第8号
  • NAID: 10025606536
  • Peer Reviewed
• [Journal Article] Enterovirus infection, CXC chemokine ligand 10(CXCL10), and CXCR3 circuit (2009)
  • Author(s): Tanaka S
  • Journal Title: Diabetes 58 Pages: 2285-2291
  • Peer Reviewed
• [Journal Article] 緩徐進行1型糖尿病(SPIDDM)の最新の知見 (2009)
  • Author(s): 小林哲郎
  • Journal Title: 糖尿病 52 Pages: 673-674
• [Journal Article] 山梨地区における糖尿病性神経障害に対するアルドース還元酵素阻害薬エパルレスタットの3年間長期投与による臨床効果-投与中止後の臨床経過も含めて- (2008)
  • Author(s): 會田薫, 土屋和子, 田中治幸, 新藤英夫, 黒沢理恵, 保坂嘉之, 祢津光廣, 井上正晴, 岩瀬英一, 小林哲郎
  • Journal Title: Diabetes Frontier 19(4) Pages: 522-527
  • Peer Reviewed
• [Presentation] シンポジウム:1型糖尿病の新しい展開.1型糖尿病の膵病変:劇症1型糖尿病と緩徐進行1型糖尿病の対比から。 (2010)
  • Author(s): 會田薫, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] 1型糖尿病の膵病変:劇症1型糖尿病と緩徐進行1型糖尿病の対比から (2010)
  • Author(s): 會田薫, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] Pathological changens in the pancreas of fulminant type 1 diabetes and slowly progressive insulin dependent (type1) diabetes. (2010)
  • Author(s): 小林哲郎, 會田薫, 田中昌一郎
  • Organizer: The 11th International Congress of the Immunology of Diabetes Society.
  • Place of Presentation: Korea
• [Presentation] Expression of salivary type amylase in human pancreatic beta cell and its induction by pro-inflammatory cytokines in MIN6 beta cells. (2010)
  • Author(s): Sayaka Yamashita, Kaoru Aida, et al.
  • Organizer: 46th Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Stockholm
• [Presentation] 劇症1型糖尿病におけるβ細胞障害のメカニズム (2009)
  • Author(s): 西田頼子
  • Organizer: 第7回1型糖尿病研究会
  • Place of Presentation: 日光市
  • Year and Date: 2009-11-07