Identification and characterization of a new factor regulating SREBP-1c gene in liver.
Project/Area Number |
20591058
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
NISHIO Yoshihiko Shiga University of Medical Science, 医学部, 准教授 (40281084)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂質合成 / 転写調節 / 栄養素 / 脂質代謝 / 肝細胞 / RBMX / 果糖 |
Research Abstract |
We have shown that RBMX and its binding protein SAFB regulate the transcriptional activity of SREBP-1c gene. Furthermore, we have identified a new gene, hepothetical protein LOC 673353, really expressing as mRNA and protein regulating SREBP-1c gene.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues.2010
Author(s)
Ugi S, Nishio Y, Yamamoto H, Ikeda K, Kobayashi M, Tsukada S, Kondo M, Morino K, Obata T, Yoshizaki T, Uzu T, Naitoh H, Tani T, Maeda S, Kashiwagi A, Maegawa H.
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Journal Title
Obesity (Silver Spring). 18(7)
Pages: 1277-1282
Related Report
Peer Reviewed
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[Journal Article] Transcription factor AP-2beta : a negative regulator of IRS-1 gene expression.2010
Author(s)
Meng X, Kondo M, Morino K, Fuke T, Obata T, Yoshizaki T, Ugi S, Nishio Y, Maeda S, Araki E, Kashiwagi A, Maegawa H.
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Journal Title
Biochem Biophys Res Commun. 19;392(4)
Pages: 526-532
Related Report
Peer Reviewed
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[Journal Article] Effects of a Fish-Based Diet on the Serum Adiponectin Concentration in Young, Non-Obese, Healthy Japanese Subjects2010
Author(s)
Kondo K, Morino K, Nishio Y, Kondo M, Fuke T, Ugi S, Iwakawa H, Kashiwagi A, Maegawa H.
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Journal Title
J Atheroscler Thromb (In press)
NAID
Related Report
Peer Reviewed
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[Journal Article] SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.2009
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A.
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Journal Title
BMB Rep. 30;42(4)
Pages: 232-237
Related Report
Peer Reviewed
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[Journal Article] Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia.2009
Author(s)
Ugi S, Shi K, Nishio Y, Shimizu S, Guo B, Sekine O, Ikeda K, Egawa K, Yoshizaki T, Nagai Y, Koya D, Takada T, Torii R, Kimura H, Kashiwagi A, MaegawaH.
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Journal Title
J Biochem. 146(4)
Pages: 541-547
NAID
Related Report
Peer Reviewed
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[Journal Article] Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia2009
Author(s)
Ugi S, Shi K, Nishio Y, Shimizu S, Guo B, Sekine O, Ikeda K, Egawa K, Yoshizaki T, Nagai Y, Koya D, Takada T, Torii R, Kimura H, Kashiwagi A, Maegawa H.
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Journal Title
J Biochem 146
Pages: 541-547
NAID
Related Report
Peer Reviewed
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[Journal Article] Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States2009
Author(s)
Azuma K, Kadowaki T, Cetinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, Nishio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A; ERA JUMP study group
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Journal Title
Metabolism 58
Pages: 1200-1207
Related Report
Peer Reviewed
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[Journal Article] SAFB1, an RBMX-Binding Protein, is a Newly Identified Regulator of Hepatic SREBP-lc Gene
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A
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Journal Title
Related Report
Peer Reviewed
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[Presentation] RNA binding motif protein on the X chromosome (RBMX), a novel key molecule for developing metabolic syndrome and NASH.2009
Author(s)
Maeno Y, Nishio Y, Nagai Y, Takemoto T, Sekine O, Omura Y, Ushio M, Kimura H, Kashiwagi A, Maegawa H
Organizer
14th International Congress of Endocrinology
Place of Presentation
Kyoto
Related Report
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[Presentation] A Newly Identified Protein, LOC673353, Activates the Promoter of SREBP-1c Gene through Direct Binding to Its Promoter and Association with a Co-Activator, RBMX.2008
Author(s)
Sekine O, Nishio Y, Ikeuchi C, Takemoto T, Quynh N, Ugi S, Maegawa H, Kimura H, Kashiwagi A
Organizer
68th annual meeting of American Diabetes Association
Place of Presentation
San Francisco
Related Report
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[Presentation] Safb1, an RBMX-Binding Protein, is a Newly Identified Activator in the Regulation of Hepatic SREBP-1 Gene Expression.2008
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A
Organizer
68th annual meeting of American Diabetes Association
Place of Presentation
San Francisco
Related Report
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