| Project/Area Number |
20591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
|
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| Research Institution | Nagasaki University |
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Principal Investigator |
KAWASAKI Eiji Nagasaki University, 病院, 准教授 (70336171)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ABIRU Norio 長崎大学, 医歯薬学総合研究科, 講師 (00380981)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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|---|
| Keywords | 1型糖尿病 / 自己抗体 / 自己抗原 / 亜鉛 / 一塩基多型 / 劇症1型糖尿病 / ラジオイッムノアッセイ / 診断 |
|---|
| Research Abstract |
In the prospective study of GAD autoantibody-positive NIDDM, the high levels of GAD autoantibody, the GAD65 middle epitope recognition, and positivity of other anti-islet autoantibodies (insulin autoantibody, IA-2 autoantibody, and ZnT8 autoantibody) were identified as predictive markers for the progression of insulin deficiency. Furthermore, multivariate logistic regression analysis of the likelihood of requiring insulin showed that only the presence of multiple islet autoantibodies was a significant predictor. Moreover, the difference of humoral autoimmune reaction to ZnT8 was proven by age of diabetes onset by the ZnT8 autoantibody epitope analysis.
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